[ASAP] The Expanding Role of Methyl-Coenzyme M Reductase in the Anaerobic Functionalization of Alkanes

[ASAP] Not All Quiet on the Sugar Front: Glycan Combatants in Host–Pathogen Interactions

Posted on Oct 6th, 2019 - By Atossa C. Ghorashi and Jennifer J. Kohler*

[ASAP] A Transient Intermediate Populated in Prion Folding Leads to Domain Swapping

Posted on Sep 26th, 2019 - By Balaka Mondal and Govardhan Reddy*

[ASAP] Decoding Principles of Selective GPCR-Ga Coupling

Posted on Sep 25th, 2019 - By Sang Min Lim*

[ASAP] Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance

Posted on Sep 23rd, 2019 - By Jason Gaglia†‡ and Stephan Kissler*†‡

[ASAP] Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates

Posted on Sep 13th, 2019 - By pthomas2

[ASAP] Replication of the Enzymatic Temperature Dependency of the Primary Hydride Kinetic Isotope Effects in Solution: Caused by the Protein-Controlled Rigidity of the Donor–Acceptor Centers?

[ASAP] Biosynthesis of GDP-<sc>d</sc>-<italic toggle=”yes”>glycero</italic>-a-<sc>d</sc>-<italic toggle=”yes”>manno</italic>-heptose for the Capsular Polysaccharide of <italic toggle=”yes”>Campylobacter jejuni</italic>

Posted on Aug 28th, 2019 - By Jamison P. Huddleston and Frank M. Raushel*

[ASAP] Functional Characterization of YdjH, a Sugar Kinase of Unknown Specificity in <italic toggle=”yes”>Escherichia coli</italic> K12

Posted on Jul 23rd, 2019 - By Jamison P. Huddleston and Frank M. Raushel*

[ASAP] Effects of Refolding on Large-Scale RNA Structure

Posted on Jul 2nd, 2019 - By Elizabeth A. Dethoff and Kevin M. Weeks*

[ASAP] Helical Behavior of the Interdomain Linker of the <italic toggle=”yes”>Escherichia coli</italic> AraC Protein

Posted on Jun 21st, 2019 - By Matthew J. Brown and Robert Schleif*

[ASAP] <italic toggle=”yes”>Vibrio natriegens</italic>: An Alternative Expression System for the High-Yield Production of Isotopically Labeled Proteins

[ASAP] Characterization of Acyl Carrier Protein-Dependent Glycosyltransferase in Mitomycin C Biosynthesis

Posted on Jun 11th, 2019 - By Hai P. Nguyen† and Kenichi Yokoyama*†‡

[ASAP] Design of a Protein Motif Responsive to Tyrosine Nitration and an Encoded Turn-Off Sensor of Tyrosine Nitration

Posted on Jun 11th, 2019 - By Andrew R. Urmey and Neal J. Zondlo*

[ASAP] Thermally versus Chemically Denatured Protein States

[ASAP] An Intermediate Conformational State of Cytochrome P450cam-CN in Complex with Putidaredoxin

[ASAP] Thrombin Exosite Maturation and Ligand Binding at ABE II Help Stabilize PAR-Binding Competent Conformation at ABE I

Posted on Feb 11th, 2019 - By Ramya Billur, T. Michael Sabo, Muriel C. Maurer

[ASAP] Cas14: Big Advances from Small CRISPR Proteins

Posted on Feb 11th, 2019 - By David F. Savage

[ASAP] Shaping the Future of Protein Engineering

Posted on Feb 6th, 2019 - By Dominic J. Glover, Dawei Xu, Douglas S. Clark

[ASAP] Retro Styles for Vesicle Coats

Posted on Jan 17th, 2019 - By James H. Hurley, Ludger Johannes

[ASAP] Targeting Type 1 Diabetes: Selective Approaches for New Therapies

[ASAP] Effector-Binding-Directed Dimerization and Dynamic Communication between Allosteric Sites of Ribonucleotide Reductase

Posted on Jan 8th, 2019 - By Bill Pham, Richard J. Lindsay, Tongye Shen

[ASAP] Tuning Protein Diffusivity with Membrane Tethers

Posted on Dec 24th, 2018 - By David Mörsdorf, Patrick Müller

[ASAP] Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells

Posted on Dec 12th, 2018 - By Brodie L. Ranzau, Alexis C. Komor

[ASAP] The Polycystin Complex Reveals Its Complexity

Posted on Dec 12th, 2018 - By Valeria Padovano, Michael J. Caplan

[ASAP] Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

[ASAP] Endoplasmic Reticulum–Endosome Contact Sites: Specialized Interfaces for Orchestrating Endosomal Tubule Fission?

Posted on Nov 30th, 2018 - By James L. Daly, Peter J. Cullen

[ASAP] Investigation of Human Neutrophil Elastase Inhibition by <italic toggle=”yes”>Staphylococcus aureus</italic> EapH1: The Key Role Played by Arginine 89

Posted on Nov 30th, 2018 - By Timothy J. Herdendorf, Brian V. Geisbrecht

[ASAP] Ancient Family of Retinal Proteins Brought to Light “Sight-Unseen”

Posted on Nov 30th, 2018 - By Thomas P. Sakmar, Thomas Huber

[ASAP] Discovery and Characterization of a Naturally Occurring, Turn-On Yellow Fluorescent Protein Sensor for Chloride

Posted on Nov 21st, 2018 - By Jasmine N. Tutol, Weicheng Peng, Sheel C. Dodani

[ASAP] Understanding and Engineering Distributed Biochemical Pathways in Microbial Communities

[ASAP] Hinge–Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity

Posted on Nov 20th, 2018 - By Tristan A. Bell, Tania A. Baker, Robert T. Sauer

[ASAP] Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTa

Posted on Nov 19th, 2018 - By Hanqiao Feng, Bing-Rui Zhou, Yawen Bai

[ASAP] In Situ Photoregulation of Carbonic Anhydrase Activity Using Azobenzenesulfonamides

[ASAP] Instantaneous Iodine-Assisted DNAzyme Cleavage of Phosphorothioate RNA

Posted on Oct 14th, 2018 - By Po-Jung Jimmy Huang, Woohyun J. Moon, Juewen Liu

[ASAP] High-Throughput Explorations of RNA Structural Modularity

Posted on Oct 14th, 2018 - By Mark A. Boerneke, Kevin M. Weeks

[ASAP] Analysis of the Ub to Ub-CR Transition in Ubiquitin

Posted on Oct 14th, 2018 - By Konstantin Röder, David J. Wales

[ASAP] Crystal Structures of Wild-Type and F448A Mutant <italic toggle=”yes”>Citrobacter freundii</italic> Tyrosine Phenol-Lyase Complexed with a Substrate and Inhibitors: Implications for the Reaction Mechanism

Posted on Oct 11th, 2018 - By Robert S. Phillips, Steven Craig

[ASAP] Characterization of Interactions and Phospholipid Transfer between Substrate Binding Proteins of the OmpC-Mla System

[ASAP] Three-Step Isomerization of the Retinal Chromophore during the Anion Pumping Cycle of Halorhodopsin

[ASAP] Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes

Posted on Oct 1st, 2018 - By Krishna Mohan Sepuru, Krishna Rajarathnam

[ASAP] Reduced Occupancy of the Oxygen-Evolving Complex of Photosystem II Detected in Cryo-Electron Microscopy Maps

[ASAP] Light at the End of the Amyloid Tunnel<subtitle>Published as part of the <italic toggle=”yes”>Biochemistry</italic> series “Biochemistry to Bedside”</subtitle>

Posted on Sep 30th, 2018 - By Dennis J. Selkoe

[ASAP] <italic toggle=”yes”>In Silico</italic> Protein Design Promotes the Rapid Evolution of Industrial Enzymes

Posted on Sep 20th, 2018 - By Yang Wang, Jian Chen, Zhen Kang

[ASAP] Caught in the Act? Quantifying Biochemistry Inside and Outside of Biomolecular Condensates

Posted on Sep 20th, 2018 - By Johannes H. Wilbertz, Jeffrey A. Chao

[ASAP] Interactions of the DNA Repair Enzyme Human Thymine DNA Glycosylase with Cognate and Noncognate DNA

Posted on Sep 19th, 2018 - By Natalia Kanaan, Petra Imhof

[ASAP] New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

Posted on Sep 18th, 2018 - By Edwin R. Ragwan, Eri Arai, Yan Kung

[ASAP] Kinetic Mechanism of Nicotinamide <italic toggle=”yes”>N</italic>-Methyltransferase

Posted on Sep 9th, 2018 - By Heather S. Loring, Paul R. Thompson

[ASAP] Variant Bacterial Riboswitches Associated with Nucleotide Hydrolase Genes Sense Nucleoside Diphosphates

[ASAP] Generation and Comparative Kinetic Analysis of New Glycosynthase Mutants from <italic toggle=”yes”>Streptococcus pyogenes</italic> Endoglycosidases for Antibody Glycoengineering

Posted on Aug 21st, 2018 - By Xin Tong, Tiezheng Li, Chao Li, Lai-Xi Wang

[ASAP] A New Class of EutT ATP:Co(I)rrinoid Adenosyltransferases Found in <italic toggle=”yes”>Listeria monocytogenes</italic> and Other <italic toggle=”yes”>Firmicutes</italic> Does Not Require a Metal Ion for Activity

Posted on Aug 15th, 2018 - By Flavia G. Costa, Jorge C. Escalante-Semerena

[ASAP] Investigation of Solvent Hydron Exchange in the Reaction Catalyzed by the Antibiotic Resistance Protein Cfr

[ASAP] Proton Transfer and Tautomerism in 2-Aminopurine–Thymine and Pyrrolocytosine–Guanine Base Pairs

Posted on Jul 18th, 2018 - By Graham D. Bull, Katherine C. Thompson

[ASAP] Functional Evaluation of the p-Helix in the NAD(P)H:FMN Reductase of the Alkanesulfonate Monooxygenase System

[ASAP] Extracellular Electron Transfer by the Gram-Positive Bacterium <italic toggle=”yes”>Enterococcus faecalis</italic>

[ASAP] Engineering a Protein Binder Specific for p38a with Interface Expansion

Posted on Jul 18th, 2018 - By Mahmud Hussain, Steven P. Angus, Brian Kuhlman

[ASAP] Kinetics and Degradation Mechanism of Adrenaline Derivative CpQ in Diluted Aqueous Solutions

[ASAP] Complete Coupled Binding–Folding Pathway of the Intrinsically Disordered Transcription Factor Protein Brinker Revealed by Molecular Dynamics Simulations and Markov State Modeling

Posted on Jul 18th, 2018 - By Andrew P. Collins, Peter C. Anderson

[ASAP] A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

[ASAP] So Close, yet Sulfur Away: Opening the Nitrogenase Cofactor Structure Creates a Binding Site

Posted on Jun 20th, 2018 - By Kazimer L. Skubi, Patrick L. Holland

[ASAP] Charge Dispersion and Its Effects on the Reactivity of Thiamin-Derived Breslow Intermediates

Posted on Jun 14th, 2018 - By Michael Bielecki, Graeme W. Howe, Ronald Kluger

[ASAP] Sulfonium Ion Condensation: The Burden Borne by SAM Synthetase

Posted on May 30th, 2018 - By Charles A. Lewis , Jr., Richard Wolfenden

[ASAP] Catalytic Bases and Stereocontrol in Lamiaceae Class II Diterpene Cyclases

[ASAP] Understanding Which Residues of the Active Site and Loop Structure of a Tyrosine Aminomutase Define Its Mutase and Lyase Activities

[ASAP] Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms

[ASAP] Second-Shell Hydrogen Bond Impacts Transition-State Structure in <italic toggle=”yes”>Bacillus subtilis</italic> Oxalate Decarboxylase

[ASAP] Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor

[ASAP] Structures of the Catalytic Domain of Bacterial Primase DnaG in Complexes with DNA Provide Insight into Key Priming Events

Posted on Mar 22nd, 2018 - By Caixia Hou, Tapan Biswas, Oleg V. Tsodikov

Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

Posted on Mar 16th, 2018 - By Erik W. Martin and Tanja Mittag

Characterization of 1,2-Propanediol Dehydratases Reveals Distinct Mechanisms for B12-Dependent and Glycyl Radical Enzymes

Posted on Mar 16th, 2018 - By Benjamin J. Levin and Emily P. Balskus

Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques

Protein Plasticity and Peptide Editing in the MHC I Antigen Processing Pathway

Posted on Feb 22nd, 2018 - By Tim Elliott and Andy van Hateren

Prediction of Hot Spots at Myeloid Cell Leukemia-1–Inhibitor Interface Using Energy Estimation and Alanine Scanning Mutagenesis

Posted on Feb 1st, 2018 - By Parthiban Marimuthu and Kalaimathy Singaravelu

Kinetic Characterization of Prenyl-Flavin Synthase from Saccharomyces cerevisiae

Posted on Dec 27th, 2017 - By Nattapol Arunrattanamook and E. Neil G. Marsh

Complexity in pH-Dependent Ribozyme Kinetics: Dark pKa Shifts and Wavy Rate–pH Profiles

Posted on Dec 22nd, 2017 - By Erica A. Frankel and Philip C. Bevilacqua

Where Informatics Lags Chemistry Leads

Posted on Dec 22nd, 2017 - By Rahul Kaushik, Ankita Singh and B. Jayaram

Structural Features and Domain Movements Controlling Substrate Binding and Cofactor Specificity in Class II HMG-CoA Reductase

Posted on Dec 21st, 2017 - By Bradley R. Miller and Yan Kung

Tuning the Flexibility of Glycine-Serine Linkers To Allow Rational Design of Multidomain Proteins

Novel Biology and Druggable Targets via Chemoproteomics

Posted on Dec 7th, 2017 - By Alan Saghatelian

Biochemical Basis of Vosevi, a New Treatment for Hepatitis C

Posted on Nov 29th, 2017 - By Ronald Besandre and Hung-wen Liu

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

Biosynthesis of an Opine Metallophore by Pseudomonas aeruginosa

Posted on Nov 3rd, 2017 - By Jeffrey S. McFarlane and Audrey L. Lamb

The Conformational Change in Elongation Factor Tu Involves Separation of Its Domains

Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

The G126V Mutation in the Mouse Prion Protein Hinders Nucleation-Dependent Fibril Formation by Slowing Initial Fibril Growth and by Increasing the Critical Concentration

Posted on Oct 26th, 2017 - By Ambadi Thody Sabareesan and Jayant B. Udgaonkar

Next-Generation Photodynamic Therapy: New Probes for Cancer Imaging and Treatment

Posted on Oct 26th, 2017 - By Andrew A. Beharry

Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning

Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability

Posted on Oct 23rd, 2017 - By Tathyana M. Amorim Franco and John S. Blanchard

Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites

Hop to It

Posted on Oct 13th, 2017 - By Jillian L. Dempsey and Matthew R. Hartings

Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner

Posted on Sep 28th, 2017 - By Xun Sun, H. Jane Dyson and Peter E. Wright

Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH as a Reductant in a Biochemical Context

Posted on Sep 27th, 2017 - By Yasunori Okamoto and Thomas R. Ward

Cation−π Lights Up “Halo”

Posted on Sep 20th, 2017 - By Jianmin Gao

Detecting Activity at Different Length Scales: From Subdiffraction to Whole-Animal Activity

Posted on Sep 15th, 2017 - By Tsz-Leung To and Xiaokun Shu

A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase

Posted on Sep 8th, 2017 - By Eric P. Trautman and Jason M. Crawford

Staphylococcus aureus CidC Is a Pyruvate:Menaquinone Oxidoreductase

Posted on Aug 25th, 2017 - By Xinyan Zhang, Kenneth W. Bayles and Sorin Luca

Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates

Posted on Aug 16th, 2017 - By Tasha B. Toro, Jenae R. Bryant and Terry J. Watt

Functional Complementation Studies Reveal Different Interaction Partners of Escherichia coli IscS and Human NFS1

Engineering Aromatic–Aromatic Interactions To Nucleate Folding in Intrinsically Disordered Regions of Proteins

Posted on Aug 11th, 2017 - By Swati Balakrishnan and Siddhartha P. Sarma

Fibronectin Conformation and Assembly: Analysis of Fibronectin Deletion Mutants and Fibronectin Glomerulopathy (GFND) Mutants