ACS Chemical Biology

[ASAP] A Nonheme Fe<sup>II</sup>/2-Oxoglutarate-Dependent Oxygenase Catalyzes a Double Bond Migration within a Dimethylallyl Moiety Accompanied by Hydroxylation

Posted on Sep 26th, 2018 - By Huomiao Ran, Viola Wohlgemuth, Xiulan Xie, Shu-Ming Li

[ASAP] Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides

Posted on Sep 24th, 2018 - By Thomas E. J. Chavas, Matthew J. Fuchter, Peter A. DiMaggio , Jr.

[ASAP] Molecular Basis for Autocatalytic Backbone <italic toggle=”yes”>N</italic>-Methylation in RiPP Natural Product Biosynthesis

Posted on Sep 24th, 2018 - By Chayanid Ongpipattanakul, Satish K. Nair

[ASAP] Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with <italic toggle=”yes”>Plasmodium falciparum</italic> Multidrug Resistance-Associated Protein and Lipids

Posted on Sep 23rd, 2018 - By John G. Woodland, Roger Hunter, Peter J. Smith, Timothy J. Egan

[ASAP] Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis

Posted on Sep 4th, 2018 - By Kelsey E. Knewtson, Digamber Rane, Blake R. Peterson

[ASAP] Human Milk Oligosaccharides (HMOs) Sensitize Group B <italic toggle=”yes”>Streptococcus</italic> to Clindamycin, Erythromycin, Gentamicin, and Minocycline on a Strain Specific Basis

Posted on Aug 5th, 2018 - By Kelly M. Craft, Jennifer A. Gaddy, Steven D. Townsend

[ASAP] Discovery of a Nitric Oxide Responsive Quorum Sensing Circuit in <italic toggle=”yes”>Vibrio cholerae</italic>

Posted on Aug 2nd, 2018 - By Sajjad Hossain, Ilana Heckler, Elizabeth M. Boon

[ASAP] Optical Recording of Zn<sup>2+</sup> Dynamics in the Mitochondrial Matrix and Intermembrane Space with the GZnP2 Sensor

Posted on Jun 25th, 2018 - By Dylan H. Fudge, Raymond Black, Lea Son, Kate LeJeune, Yan Qin

[ASAP] ICBS 2017 in Shanghai—Illuminating Life with Chemical Innovation

Posted on May 1st, 2018 - By Qi Zhang, Jingyu Zhang, Evripidis Gavathiotis

[ASAP] Neuronal Calcium Recording with an Engineered TEV Protease

Posted on May 1st, 2018 - By Brianna K. O’Neill, Scott T. Laughlin

[ASAP] Protein Acylation Affects the Artificial Biosynthetic Pathway for Pinosylvin Production in Engineered <italic toggle=”yes”>E. coli</italic>

Posted on Apr 24th, 2018 - By Jun-Yu Xu, Ya Xu, Xiaohe Chu, Minjia Tan, Bang-Ce Ye

[ASAP] A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance

Posted on Mar 21st, 2018 - By James H. Matthews, Xiao Liang, Valerie J. Paul, Hendrik Luesch

Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia

Posted on Mar 9th, 2018 - By Hailey J. Knox, Tae Wook Kim, Zhouyang Zhu and Jefferson Chan

More Than a Light Switch: Engineering Unconventional Fluorescent Configurations for Biological Sensing

Posted on Feb 20th, 2018 - By William J. Peveler and W. Russ Algar

Understanding the Molecular Mechanisms of the CRISPR Toolbox Using Single Molecule Approaches

Posted on Feb 9th, 2018 - By Digvijay Singh and Taekjip Ha

Development of Activity-Based Chemical Probes for Human Sirtuins

Posted on Feb 8th, 2018 - By Elysian Graham, Stacia Rymarchyk, Marci Wood and Yana Cen

Toward a Microparticle-Based System for Pooled Assays of Small Molecules in Cellular Contexts

Posted on Feb 8th, 2018 - By Carrie E. Yozwiak, Tal Hirschhorn and Brent R. Stockwell

Identifying Novel Enhancer Elements with CRISPR-Based Screens

Posted on Jan 10th, 2018 - By Jason C. Klein, Wei Chen, Molly Gasperini and Jay Shendure

Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors

Posted on Jan 4th, 2018 - By Ganglin Wang, Zhi Li and Nan Ma

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017Utility and Limitations

Posted on Dec 26th, 2017 - By Jonathan B. Baell and J. Willem M. Nissink

Fluorescent Probes of DNA Repair

Posted on Nov 30th, 2017 - By David L. Wilson and Eric T. Kool

Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2

Posted on Nov 30th, 2017 - By Myung-Ryul Lee, Namrata Raman, Samuel H. Gellman, David M. Lynn and Sean P. Palecek

Repair of a Site-Specific DNA Cleavage: Old-School Lessons for Cas9-Mediated Gene Editing

Posted on Nov 14th, 2017 - By Danielle N. Gallagher and James E. Haber

Large Scale Mutational and Kinetic Analysis of a Self-Hydrolyzing Deoxyribozyme

Posted on Nov 3rd, 2017 - By V. Dhamodharan, Shungo Kobori and Yohei Yokobayashi

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine

Posted on Oct 24th, 2017 - By Martin Kampmann

Ionic Strength Sensing in Living Cells

Posted on Sep 6th, 2017 - By Boqun Liu, Bert Poolman and Arnold J. Boersma

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8

Posted on Aug 30th, 2017 - By Nicholas J. Porter and David W. Christianson

Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae

Posted on Aug 24th, 2017 - By Choong-Soo Yun, Takayuki Motoyama and Hiroyuki Osada

Streptomyces virginiae PPDC Is a New Type of Phenylpyruvate Decarboxylase Composed of Two Subunits

Posted on Jul 18th, 2017 - By Xiaoshu Xu, Chao Wang, Jun Chen and Sheng Yang

Celiac Disease: Lessons for and from Chemical Biology

Posted on May 22nd, 2017 - By Chaitan Khosla

Hidden Antioxidative Functions of Reduced Nicotinamide Adenine Dinucleotide Coexisting with Hemoglobin

Posted on May 19th, 2017 - By Magohei Yamada and Hiromi Sakai

Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor

Posted on Mar 22nd, 2017 - By S. Denise Field, Jacob Arkin, Jing Li and Lyn H. Jones

Differential Ability of Five DNA Glycosylases to Recognize and Repair Damage on Nucleosomal DNA

Posted on Jan 23rd, 2017 - By Eric D. Olmon and Sarah Delaney

Duration Control of Protein Expression in Vivo by Light-Mediated Reversible Activation of Translation

Posted on Jan 4th, 2017 - By Shinzi Ogasawara

A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation

Posted on Dec 29th, 2016 - By Brittany A. Moser and Aaron P. Esser-Kahn

Temporal Analysis of PP2A Phosphatase Activity During Insulin Stimulation Using a Direct Activity Probe

Posted on Nov 7th, 2016 - By Jon R. Beck, Tiffany Truong and Cliff I. Stains

Host Cell Interactions Are a Significant Barrier to the Clinical Utility of Peptide Antibiotics

Posted on Nov 7th, 2016 - By Charles G. Starr, Jing He and William C. Wimley

Fluorescence-Activated Cell Sorting of Human l-asparaginase Mutant Libraries for Detecting Enzyme Variants with Enhanced Activity

Posted on Aug 1st, 2016 - By Christos S. Karamitros and Manfred Konrad

pH-Dependent DNA Distortion and Repression of Gene Expression by Pectobacterium atrosepticum PecS

Posted on May 27th, 2016 - By Dinesh K. Deochand, Jacob K. Meariman and Anne Grove

Advances in Enzymatic Glycoside Synthesis

Posted on May 26th, 2016 - By Phillip M. Danby and Stephen G. Withers

The Chemical Ecology of Predatory Soil Bacteria

Posted on Apr 14th, 2016 - By Brandon L. Findlay

Chemically Modifying Viruses for Diverse Applications

Posted on Mar 21st, 2016 - By Kritika Mohan and Gregory A. Weiss

Why Nature Chose Selenium

Posted on Mar 21st, 2016 - By Hans J. Reich and Robert J. Hondal

A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins

Posted on Feb 5th, 2016 - By Lisa M. Yates and Dorothea Fiedler

Sirtuins 1 and 2 Are Universal Histone Deacetylases

Posted on Feb 5th, 2016 - By Willie W. Hsu, Bo Wu and Wenshe R. Liu

Probing Chromatin-modifying Enzymes with Chemical Tools

Posted on Feb 4th, 2016 - By Wolfgang Fischle and Dirk Schwarzer

Protein Arginine Methylation and Citrullination in Epigenetic Regulation

Posted on Dec 31st, 2015 - By Jakob Fuhrmann and Paul R. Thompson

Human Telomere G-Quadruplexes with Five Repeats Accommodate 8-Oxo-7,8-dihydroguanine by Looping out the DNA Damage

Posted on Dec 29th, 2015 - By Na An, Aaron M. Fleming and Cynthia J. Burrows

Boronic Acid for the Traceless Delivery of Proteins into Cells

Posted on Dec 15th, 2015 - By pthomas2

Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR

Posted on Dec 14th, 2015 - By pthomas2

Three Residues Make an Evolutionary Switch for Folding and RNA-Destabilizing Activity in the TTP Family of Proteins

Posted on Dec 14th, 2015 - By Laura M. Deveau and Francesca Massi

Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo

Posted on Dec 14th, 2015 - By pthomas2

Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue

Posted on Dec 14th, 2015 - By Feifei Zhang, Chaoxuan Li and Wendy L. Kelly

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

Posted on Dec 10th, 2015 - By pthomas2

Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities

Posted on Dec 9th, 2015 - By pthomas2

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Posted on Dec 8th, 2015 - By pthomas2

In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish

Posted on Dec 8th, 2015 - By pthomas2

Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma

Posted on Dec 7th, 2015 - By Jessica L. Childs-Disney and Matthew D. Disney

Reading between the Lines: “ADD”-ing Histone and DNA Methylation Marks toward a New Epigenetic “Sum”

Posted on Dec 7th, 2015 - By Kyung-Min Noh, C. David Allis and Haitao Li

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

Posted on Dec 7th, 2015 - By pthomas2

Rational Design of a Dephosphorylation-Resistant Reporter Enables Single-Cell Measurement of Tyrosine Kinase Activity

Posted on Dec 4th, 2015 - By pthomas2

Dynamic Docking of Conformationally Constrained Macrocycles: Methods and Applications

Posted on Dec 4th, 2015 - By pthomas2

Copper and Zinc Ions Specifically Promote Nonamyloid Aggregation of the Highly Stable Human γ-D Crystallin

Posted on Dec 3rd, 2015 - By pthomas2

Interrogating Endogenous Protein Phosphatase Activity with Rationally Designed Chemosensors

Posted on Dec 3rd, 2015 - By pthomas2

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

Posted on Dec 3rd, 2015 - By pthomas2

The Bromodomain: A New Target in Emerging Epigenetic Medicine

Posted on Dec 3rd, 2015 - By Steven G. Smith and Ming-Ming Zhou

Single Site Discrimination of Cytosine, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Target DNA Using Anthracene-Tagged Fluorescent Probes

Posted on Dec 3rd, 2015 - By pthomas2

Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and Autoacetylation

Posted on Dec 2nd, 2015 - By Cheryl E. McCullough and Ronen Marmorstein

Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity

Posted on Nov 30th, 2015 - By pthomas2

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues

Posted on Nov 25th, 2015 - By pthomas2

Dynamic Chromatin Regulation from a Single Molecule Perspective

Posted on Nov 25th, 2015 - By Beat Fierz

Environmentally Robust Rhodamine Reporters for Probe-based Cellular Detection of the Cancer-linked Oxidoreductase hNQO1

Posted on Nov 25th, 2015 - By pthomas2

New Simocyclinones: Surprising Evolutionary and Biosynthetic Insights

Posted on Nov 25th, 2015 - By pthomas2

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions

Posted on Nov 25th, 2015 - By pthomas2

Artificial Avidin-Based Receptors for a Panel of Small Molecules

Posted on Nov 23rd, 2015 - By pthomas2

Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates

Posted on Nov 23rd, 2015 - By pthomas2

Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1

Posted on Nov 19th, 2015 - By pthomas2

Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells

Posted on Nov 19th, 2015 - By pthomas2

Enhanced Cross-Linking of Diazirine-Modified Sialylated Glycoproteins Enabled through Profiling of Sialidase Specificities

Posted on Nov 16th, 2015 - By pthomas2

SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases

Posted on Nov 16th, 2015 - By Jing Zhang and Yujun George Zheng

Structural Chemistry of Human RNA Methyltransferases

Posted on Nov 13th, 2015 - By Matthieu Schapira

First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis

Posted on Nov 11th, 2015 - By pthomas2

Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity

Posted on Nov 11th, 2015 - By pthomas2

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction

Posted on Nov 10th, 2015 - By pthomas2

Switching the Regioselectivity of a Cyclohexanone Monooxygenase toward (+)-trans-Dihydrocarvone by Rational Protein Design

Posted on Nov 9th, 2015 - By pthomas2

PDZ-Reactive Peptide Activates Ephrin-B Reverse Signaling and Inhibits Neuronal Chemotaxis

Posted on Nov 9th, 2015 - By pthomas2

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

Posted on Nov 6th, 2015 - By pthomas2

Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity

Posted on Nov 6th, 2015 - By pthomas2

Self-Assembling NanoLuc Luciferase Fragments as Probes for Protein Aggregation in Living Cells

Posted on Nov 6th, 2015 - By pthomas2

Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus

Posted on Nov 5th, 2015 - By pthomas2

Single-Cell, Time-Resolved Antimicrobial Effects of a Highly Cationic, Random Nylon-3 Copolymer on Live Escherichia coli

Posted on Nov 5th, 2015 - By pthomas2

Chemical Tools for the Study of Intramembrane Proteases

Posted on Nov 5th, 2015 - By pthomas2

Detection and Quantification of Ribosome Inhibition by Aminoglycoside Antibiotics in Living Bacteria Using an Orthogonal Ribosome-Controlled Fluorescent Reporter

Posted on Nov 4th, 2015 - By Shijie Huang, Xuechen Zhu and Charles E. Melançon

In Vitro and in Vivo Demonstration of Photodynamic Activity and Cytoplasm Imaging through TPE Nanoparticles

Posted on Nov 4th, 2015 - By pthomas2

Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis

Posted on Nov 3rd, 2015 - By pthomas2

Investigation of Specific Binding Proteins to Photoaffinity Linkers for Efficient Deconvolution of Target Protein

Posted on Nov 3rd, 2015 - By pthomas2

N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA

Posted on Nov 3rd, 2015 - By pthomas2

Deconstructing the Iboga Alkaloid Skeleton: Potentiation of FGF2-induced Glial Cell Line-Derived Neurotrophic Factor Release by a Novel Compound

Posted on Oct 30th, 2015 - By pthomas2

The Supersized Class III Lanthipeptide Stackepeptin Displays Motif Multiplication in the Core Peptide

Posted on Oct 29th, 2015 - By pthomas2

Construction of Lasso Peptide Fusion Proteins

Posted on Oct 29th, 2015 - By Chuhan Zong, Mikhail O. Maksimov and A. James Link