The G126V Mutation in the Mouse Prion Protein Hinders Nucleation-Dependent Fibril Formation by Slowing Initial Fibril Growth and by Increasing the Critical Concentration

October 26th, 2017 by Ambadi Thody Sabareesan and Jayant B. Udgaonkar

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Biochemistry
DOI: 10.1021/acs.biochem.7b00894

Next-Generation Photodynamic Therapy: New Probes for Cancer Imaging and Treatment

October 26th, 2017 by Andrew A. Beharry

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Biochemistry
DOI: 10.1021/acs.biochem.7b01037

Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning

October 26th, 2017 by Haobo Wang, Xuemin Chen, Can Li, Yuan Liu, Fan Yang and Chu Wang

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Biochemistry
DOI: 10.1021/acs.biochem.7b00897

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine

October 24th, 2017 by Martin Kampmann

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00657

Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability

October 23rd, 2017 by Tathyana M. Amorim Franco and John S. Blanchard

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Biochemistry
DOI: 10.1021/acs.biochem.7b00849

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

October 23rd, 2017 by Chia-Wei Hu

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase, Published online: 23 October 2017; doi:10.1038/nchembio.2494

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N-Acetylglucosamine derivatives equipped with electrophilic groups and handles for subsequent chemical tagging are useful probes of substrate recognition by O-GlcNAc transferases and enable the capture of transient protein substrates of these enzymes.

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Rational design of proteins that exchange on functional timescales

October 23rd, 2017 by James A Davey

Rational design of proteins that exchange on functional timescales

Rational design of proteins that exchange on functional timescales, Published online: 23 October 2017; doi:10.1038/nchembio.2503

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The development of a computational protein design method, meta-multistate design, enables the design and validation of protein variants termed DANCERs that spontaneously exchange between predicted conformational states on the millisecond timescale.

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A CRISPR screen identifies a pathway required for paraquat-induced cell death

October 23rd, 2017 by Colleen R Reczek

A CRISPR screen identifies a pathway required for paraquat-induced cell death

A CRISPR screen identifies a pathway required for paraquat-induced cell death, Published online: 23 October 2017; doi:10.1038/nchembio.2499

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A positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

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Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites

October 18th, 2017 by Jack G. Ganley, Maria Toro-Moreno and Emily R. Derbyshire

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Biochemistry
DOI: 10.1021/acs.biochem.7b00877

Bacterial cell wall: Phages breaking free

October 18th, 2017 by Karin Kuehnel

Bacterial cell wall: Phages breaking free

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2506