Fluorescence-Activated Cell Sorting of Human l-asparaginase Mutant Libraries for Detecting Enzyme Variants with Enhanced Activity

August 1st, 2016 by Christos S. Karamitros and Manfred Konrad

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ACS Chemical Biology
DOI: 10.1021/acschembio.6b00283
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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

August 1st, 2016 by Aaron Boudreau

Nature Chemical Biology 12, 779 (2016). doi:10.1038/nchembio.2143

Authors: Aaron Boudreau, Hans E Purkey, Anna Hitz, Kirk Robarge, David Peterson, Sharada Labadie, Mandy Kwong, Rebecca Hong, Min Gao, Christopher Del Nagro, Raju Pusapati, Shuguang Ma, Laurent Salphati, Jodie Pang, Aihe Zhou, Tommy Lai, Yingjie Li, Zhongguo Chen, Binqing Wei, Ivana Yen, Steve Sideris, Mark McCleland, Ron Firestein, Laura Corson, Alex Vanderbilt, Simon Williams, Anneleen Daemen, Marcia Belvin, Charles Eigenbrot, Peter K Jackson, Shiva Malek, Georgia Hatzivassiliou, Deepak Sampath, Marie Evangelista & Thomas O'Brien

  • Posted in Nat Chem Biol, Publications
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An histidine covalent receptor and butenolide complex mediates strigolactone perception

August 1st, 2016 by Alexandre de Saint Germain

Nature Chemical Biology 12, 787 (2016). doi:10.1038/nchembio.2147

Authors: Alexandre de Saint Germain, Guillaume Clavé, Marie-Ange Badet-Denisot, Jean-Paul Pillot, David Cornu, Jean-Pierre Le Caer, Marco Burger, Frank Pelissier, Pascal Retailleau, Colin Turnbull, Sandrine Bonhomme, Joanne Chory, Catherine Rameau & François-Didier Boyer

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Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

July 25th, 2016 by Yasuyuki Miyake

Nature Chemical Biology 12, 748 (2016). doi:10.1038/nchembio.2140

Authors: Yasuyuki Miyake, Jeremy J Keusch, Longlong Wang, Makoto Saito, Daniel Hess, Xiaoning Wang, Bruce J Melancon, Paul Helquist, Heinz Gut & Patrick Matthias

  • Posted in Nat Chem Biol, Publications
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Photoswitchable diacylglycerols enable optical control of protein kinase C

July 25th, 2016 by James Allen Frank

Nature Chemical Biology 12, 755 (2016). doi:10.1038/nchembio.2141

Authors: James Allen Frank, Dmytro A Yushchenko, David J Hodson, Noa Lipstein, Jatin Nagpal, Guy A Rutter, Jeong-Seop Rhee, Alexander Gottschalk, Nils Brose, Carsten Schultz & Dirk Trauner

  • Posted in Nat Chem Biol, Publications
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Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

July 25th, 2016 by Yang Hai

Nature Chemical Biology 12, 741 (2016). doi:10.1038/nchembio.2134

Authors: Yang Hai & David W Christianson

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Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

July 19th, 2016 by Michael E Pacold

Nature Chemical Biology 12, 656 (2016). doi:10.1038/nchembio0816-656

Author: Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, Jason M Rohde, Caroline A Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W Chen, Lucas B Sullivan, Brian P Fiske, Steve Cho, Elizaveta Freinkman, Kıvanç Birsoy, Monther-Remaileh Abu, Yoav D Shaul, Chieh Min Liu, Minerva Zhou, Min Jung Koh, Haeyoon Chung, Shawn M Davidson, Alba Luengo, Amy Q Wang, Xin Xu, Adam Yasgar, Li Liu, Ganesha Rai, Kenneth D Westover, Matthew G Vander Heiden, Min Shen, Nathanael S Gray, Matthew B Boxer & David M Sabatini

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Chaperones: Speedy motion for function

July 19th, 2016 by Hagen Hofmann

Nature Chemical Biology 12, 576 (2016). doi:10.1038/nchembio.2130

Author: Hagen Hofmann

Hsp90 is an energy-consuming molecular chaperone that activates oncogenic proteins in a complicated multi-step reaction. Photoinduced electron transfer (PET) quenching experiments with a fluorescent reporter have now identified molecular transitions at multiple timescales in the chaperone cycle of Hsp90.

Antibiotics: I want a new drug

July 19th, 2016 by Joshua M. Finkelstein

Nature Chemical Biology 12, 575 (2016). doi:10.1038/nchembio.2137

Author: Joshua M. Finkelstein

Glycomics: Highlights for carbohydrates

July 19th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 575 (2016). doi:10.1038/nchembio.2136

Author: Terry L. Sheppard