Protein evolution: Polymerase’s new language

May 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2094

Author: Caitlin Deane

Proteostasis: Chaperoning for hearing loss

May 18th, 2016 by Gergely L Lukacs

Nature Chemical Biology 12, 388 (2016). doi:10.1038/nchembio.2091

Author: Gergely L Lukacs

A small molecule has been identified that can mitigate the progression of an inherited form of deafness in transgenic mice by stabilizing mutant clarin-1, an essential component of a multimolecular complex of the mechanotransduction apparatus of hair cells in the inner ear.

Metalloproteins: Mapping elusive electron density

May 18th, 2016 by Louis Noodleman

Nature Chemical Biology 12, 391 (2016). doi:10.1038/nchembio.2088

Author: Louis Noodleman

Iron–sulfur metalloproteins are critical for electron transfer in bacterial metabolism, but most crystal structures are insufficient for their in-depth study. Now, acquisition of an iron–sulfur protein structure at ultra-high resolution enables detailed visualization of its electron distribution.

Cancer metabolism: Addicted to serine

May 18th, 2016 by Christian Frezza

Nature Chemical Biology 12, 389 (2016). doi:10.1038/nchembio.2086

Author: Christian Frezza

Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors selectively block proliferation of PHGDH-dependent cancer cells and reveal an unexpected role of serine biosynthesis in coordinating one-carbon metabolism.

Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera

May 18th, 2016 by Stavroula K Hatzios

Nature Chemical Biology 12, 466 (2016). doi:10.1038/nchembio0616-466

Author: Stavroula K Hatzios, Sören Abel, Julianne Martell, Troy Hubbard, Jumpei Sasabe, Diana Munera, Lars Clark, Daniel A Bachovchin, Firdausi Qadri, Edward T Ryan, Brigid M Davis, Eranthie Weerapana & Matthew K Waldor

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Lighting the way

May 18th, 2016 by Nature Chemical Biology - Issue - science feeds

Nature Chemical Biology 12, 381 (2016). doi:10.1038/nchembio.2101

The innovation and optimization of optogenetic tools are providing new insights into biological and cellular processes with unparalleled spatiotemporal resolution.

Gene expression: Means to an end

May 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2093

Author: Terry L. Sheppard

Designing convergent chemistry curricula

May 18th, 2016 by Louise K Charkoudian

Nature Chemical Biology 12, 382 (2016). doi:10.1038/nchembio.2090

Authors: Louise K Charkoudian, Nicole S Sampson, Krishna Kumar & Joshua A Kritzer

Scientific convergence is a common theme of modern research, but undergraduate chemistry is commonly taught as an isolated discipline. Here we discuss curricular updates at three different institutions that are independently seeking to increase convergence in introductory chemistry courses.

Host–microbe interactions: Inflammation sop-up

May 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2095

Author: Mirella Bucci

Genomics: A Tribe for RNA

May 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2092

Author: Grant Miura