σ1 receptor ligands control a switch between passive and active threat responses

May 30th, 2016 by Andrew J Rennekamp

Nature Chemical Biology 12, 552 (2016). doi:10.1038/nchembio.2089

Authors: Andrew J Rennekamp, Xi-Ping Huang, You Wang, Samir Patel, Paul J Lorello, Lindsay Cade, Andrew P W Gonzales, Jing-Ruey Joanna Yeh, Barbara J Caldarone, Bryan L Roth, David Kokel & Randall T Peterson

  • Posted in Nat Chem Biol, Publications
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pH-Dependent DNA Distortion and Repression of Gene Expression by Pectobacterium atrosepticum PecS

May 27th, 2016 by Dinesh K. Deochand, Jacob K. Meariman and Anne Grove

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.6b00168
  • Posted in ACS Chemical Biology, Publications
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Advances in Enzymatic Glycoside Synthesis

May 26th, 2016 by Phillip M. Danby and Stephen G. Withers

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.6b00340

Structural analysis of human KDM5B guides histone demethylase inhibitor development

May 23rd, 2016 by Catrine Johansson

Nature Chemical Biology 12, 539 (2016). doi:10.1038/nchembio.2087

Authors: Catrine Johansson, Srikannathasan Velupillai, Anthony Tumber, Aleksandra Szykowska, Edward S Hookway, Radoslaw P Nowak, Claire Strain-Damerell, Carina Gileadi, Martin Philpott, Nicola Burgess-Brown, Na Wu, Jola Kopec, Andrea Nuzzi, Holger Steuber, Ursula Egner, Volker Badock, Shonagh Munro, Nicholas B LaThangue, Sue Westaway, Jack Brown, Nick Athanasou, Rab Prinjha, Paul E Brennan & Udo Oppermann

  • Posted in Nat Chem Biol, Publications
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NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet

May 23rd, 2016 by Saori Nakano

Nature Chemical Biology 12, 546 (2016). doi:10.1038/nchembio.2099

Authors: Saori Nakano, Takeo Suzuki, Layla Kawarada, Hiroyoshi Iwata, Kana Asano & Tsutomu Suzuki

  • Posted in Nat Chem Biol, Publications
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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

May 23rd, 2016 by Maia Vinogradova

Nature Chemical Biology 12, 531 (2016). doi:10.1038/nchembio.2085

Authors: Maia Vinogradova, Victor S Gehling, Amy Gustafson, Shilpi Arora, Charles A Tindell, Catherine Wilson, Kaylyn E Williamson, Gulfem D Guler, Pranoti Gangurde, Wanda Manieri, Jennifer Busby, E Megan Flynn, Fei Lan, Hyo-jin Kim, Shobu Odate, Andrea G Cochran, Yichin Liu, Matthew Wongchenko, Yibin Yang, Tommy K Cheung, Tobias M Maile, Ted Lau, Michael Costa, Ganapati V Hegde, Erica Jackson, Robert Pitti, David Arnott, Christopher Bailey, Steve Bellon, Richard T Cummings, Brian K Albrecht, Jean-Christophe Harmange, James R Kiefer, Patrick Trojer & Marie Classon

  • Posted in Nat Chem Biol, Publications
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Host–microbe interactions: Inflammation sop-up

May 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2095

Author: Mirella Bucci

Genomics: A Tribe for RNA

May 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2092

Author: Grant Miura

Protein evolution: Polymerase’s new language

May 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2094

Author: Caitlin Deane

Proteostasis: Chaperoning for hearing loss

May 18th, 2016 by Gergely L Lukacs

Nature Chemical Biology 12, 388 (2016). doi:10.1038/nchembio.2091

Author: Gergely L Lukacs

A small molecule has been identified that can mitigate the progression of an inherited form of deafness in transgenic mice by stabilizing mutant clarin-1, an essential component of a multimolecular complex of the mechanotransduction apparatus of hair cells in the inner ear.