Freedom of movement

January 21st, 2019 by Ulrich Rass

Freedom of movement

Freedom of movement, Published online: 21 January 2019; doi:10.1038/s41589-019-0224-7

Holliday junction resolvases lock dynamic DNA four-way junctions into specific structural conformations for symmetric DNA cleavage. Single-molecule studies now reveal that resolvases can relax their grip, enabling Holliday junction conformer transitions and branch migration in the enzyme-bound form.

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

January 21st, 2019 by Ruobo Zhou

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic, Published online: 21 January 2019; doi:10.1038/s41589-018-0209-y

Single-molecule analysis reveals a novel binding state of Holliday junction (HJ) resolving enzymes where the enzymes partially dissociate from the HJ and allowing nearly unencumbered HJ dynamics, suggesting coupled branch migration and HJ resolution.
  • Posted in Nat Chem Biol, Publications
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Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum

January 21st, 2019 by Xiaoxue Zhou

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum, Published online: 21 January 2019; doi:10.1038/s41589-018-0206-1

Assembly of the mycobacterial cell envelope layers, including peptidoglycan (PG) and the mycomembrane (MM), is synchronous during elongation, when a mobile fraction of the MM diffuses into the septum after thinning of the diffusion barrier formed by PG.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Engineering a New Class of Anti-LacI Transcription Factors with Alternate DNA Recognition

January 20th, 2019 by Ronald E. Rondon, Corey J. Wilson

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00324

A new Tar-get for inhibition

January 18th, 2019 by Mirella Bucci

A new Tar-get for inhibition

A new Tar-get for inhibition, Published online: 18 January 2019; doi:10.1038/s41589-018-0220-3

A new Tar-get for inhibition

Pass it along

January 18th, 2019 by Yiyun Song

Pass it along

Pass it along, Published online: 18 January 2019; doi:10.1038/s41589-018-0221-2

Pass it along

Cutting in choline

January 18th, 2019 by Caitlin Deane

Cutting in choline

Cutting in choline, Published online: 18 January 2019; doi:10.1038/s41589-018-0218-x

Cutting in choline

Ras tuning

January 18th, 2019 by Grant Miura

Ras tuning

Ras tuning, Published online: 18 January 2019; doi:10.1038/s41589-018-0219-9

Ras tuning

Molecular tools for imaging and recording neuronal activity

January 18th, 2019 by Wenjing Wang

Molecular tools for imaging and recording neuronal activity

Molecular tools for imaging and recording neuronal activity, Published online: 18 January 2019; doi:10.1038/s41589-018-0207-0

A collection of genetically encoded tools, each with their own capabilities, limitations and performance characteristics, are available for monitoring and manipulating neuronal activity that could allow visualizing the brain at single-cell resolution.

[ASAP] Synthetic Transcription Factors Switch from Local to Long-Range Control during Cell Differentiation

January 17th, 2019 by Takeo Wada, Sandrine Wallerich, Attila Becskei

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00369
  • Posted in ACS Synthetic Biology, Publications
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