The molecular language of membraneless organelles [Cell Biology]

July 25th, 2018 by Edward Gomes, James Shorter

Eukaryotic cells organize their intracellular components into organelles that can be membrane-bound or membraneless. A large number of membraneless organelles, including nucleoli, Cajal bodies, P-bodies, and stress granules, exist as liquid droplets within the cell and arise from the condensation of cellular material in a process termed liquid-liquid phase separation (LLPS). Beyond a mere organizational tool, concentrating cellular components into membraneless organelles tunes biochemical reactions and improves cellular fitness during stress. In this review, we provide an overview of the molecular underpinnings of the formation and regulation of these membraneless organelles. This molecular understanding explains emergent properties of these membraneless organelles and shines new light on neurodegenerative diseases, which may originate from disturbances in LLPS and membraneless organelles.

[ASAP] Investigation of Solvent Hydron Exchange in the Reaction Catalyzed by the Antibiotic Resistance Protein Cfr

July 22nd, 2018 by Matthew R. Bauerle, Tyler L. Grove, Squire J. Booker

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Biochemistry
DOI: 10.1021/acs.biochem.8b00347

[ASAP] Tight Translational Control Using Site-Specific Unnatural Amino Acid Incorporation with Positive Feedback Gene Circuits

July 19th, 2018 by Yusuke Kato

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00204
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[ASAP] Kinetics and Degradation Mechanism of Adrenaline Derivative CpQ in Diluted Aqueous Solutions

July 18th, 2018 by Andrei Blasko, James Tam, Sajeevi Gunasekera, Ale Eboreime

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Biochemistry
DOI: 10.1021/acs.biochem.8b00462

[ASAP] Complete Coupled Binding–Folding Pathway of the Intrinsically Disordered Transcription Factor Protein Brinker Revealed by Molecular Dynamics Simulations and Markov State Modeling

July 18th, 2018 by Andrew P. Collins, Peter C. Anderson

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Biochemistry
DOI: 10.1021/acs.biochem.8b00441

[ASAP] Proton Transfer and Tautomerism in 2-Aminopurine–Thymine and Pyrrolocytosine–Guanine Base Pairs

July 18th, 2018 by Graham D. Bull, Katherine C. Thompson

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Biochemistry
DOI: 10.1021/acs.biochem.8b00521

[ASAP] Functional Evaluation of the p-Helix in the NAD(P)H:FMN Reductase of the Alkanesulfonate Monooxygenase System

July 18th, 2018 by Jonathan M. Musila, Dianna L. Forbes, Holly R. Ellis

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Biochemistry
DOI: 10.1021/acs.biochem.8b00544

[ASAP] Extracellular Electron Transfer by the Gram-Positive Bacterium <italic toggle=”yes”>Enterococcus faecalis</italic>

July 18th, 2018 by Galina Pankratova, Dónal Leech, Lo Gorton, Lars Hederstedt

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Biochemistry
DOI: 10.1021/acs.biochem.8b00600

[ASAP] Engineering a Protein Binder Specific for p38a with Interface Expansion

July 18th, 2018 by Mahmud Hussain, Steven P. Angus, Brian Kuhlman

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Biochemistry
DOI: 10.1021/acs.biochem.8b00408

Caught in the act

July 17th, 2018 by Karin Kuehnel

Caught in the act

Caught in the act, Published online: 17 July 2018; doi:10.1038/s41589-018-0110-8

Caught in the act