Redox regulation: Taking AKTion on HNEs

January 23rd, 2017 by Eranthie Weerapana

Nature Chemical Biology 13, 244 (2017). doi:10.1038/nchembio.2311

Author: Eranthie Weerapana

Differential redox regulation of kinase isoforms serves to provide intricate control of cellular signaling events. In a new study, a single isoform of Akt, Akt3, is shown to be preferentially modified by lipid-derived electrophiles to modulate downstream signaling events in mammalian cells and zebrafish.

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

January 23rd, 2017 by Kenneth D Bromberg

Nature Chemical Biology 13, 317 (2017). doi:10.1038/nchembio.2282

Authors: Kenneth D Bromberg, Taylor R H Mitchell, Anup K Upadhyay, Clarissa G Jakob, Manisha A Jhala, Kenneth M Comess, Loren M Lasko, Conglei Li, Creighton T Tuzon, Yujia Dai, Fengling Li, Mohammad S Eram, Alexander Nuber, Niru B Soni, Vlasios Manaves, Mikkel A Algire, Ramzi F Sweis, Maricel Torrent, Gunnar Schotta, Chaohong Sun, Michael R Michaelides, Alex R Shoemaker, Cheryl H Arrowsmith, Peter J Brown, Vijayaratnam Santhakumar, Alberto Martin, Judd C Rice, Gary G Chiang, Masoud Vedadi, Dalia Barsyte-Lovejoy & William N Pappano

  • Posted in Nat Chem Biol, Publications
  • Comments Off on The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Akt3 is a privileged first responder in isozyme-specific electrophile response

January 23rd, 2017 by Marcus J C Long

Nature Chemical Biology 13, 333 (2017). doi:10.1038/nchembio.2284

Authors: Marcus J C Long, Saba Parvez, Yi Zhao, Sanjna L Surya, Yiran Wang, Sheng Zhang & Yimon Aye

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Akt3 is a privileged first responder in isozyme-specific electrophile response

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis

January 23rd, 2017 by Yi Zou

Nature Chemical Biology 13, 325 (2017). doi:10.1038/nchembio.2283

Authors: Yi Zou, Marc Garcia-Borràs, Mancheng C Tang, Yuichiro Hirayama, Dehai H Li, Li Li, Kenji Watanabe, K N Houk & Yi Tang

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis

Host-Pathogen interactions: Nucleotide circles of life and death

January 19th, 2017 by Lingyin Li

Nature Chemical Biology 13, 130 (2017). doi:10.1038/nchembio.2289

Author: Lingyin Li

A phosphodiesterase, CdnP, from Mycobacterium tuberculosis (M. tb.) helps the pathogen evade immune detection by degrading the second messenger cyclic di-AMP that alerts the host to its presence. Genetic knockout of CdnP dampens the virulence of the pathogen, suggesting that CdnP inhibitors are potential anti–M. tb. therapeutics.

Pancreatic development: Changing identity

January 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2293

Author: Grant Miura

Target engagement: Shining a light

January 19th, 2017 by Kilian V M Huber

Nature Chemical Biology 13, 133 (2017). doi:10.1038/nchembio.2295

Author: Kilian V M Huber

The ability to measure the binding of a compound to its intended target in live cells or tissue is a critical parameter for drug discovery. A new method using polarized light microscopy adds to the current toolbox by enabling monitoring of target engagement in vitro and in vivo at single-cell resolution.

RNA structure: Untying Zika’s knots

January 19th, 2017 by Terry L. Sheppard

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2294

Author: Terry L. Sheppard

The pharmacological regulation of cellular mitophagy

January 19th, 2017 by Nikolaos D Georgakopoulos

Nature Chemical Biology 13, 136 (2017). doi:10.1038/nchembio.2287

Authors: Nikolaos D Georgakopoulos, Geoff Wells & Michelangelo Campanella

Synthetic biology: Sensing with modular receptors

January 19th, 2017 by Matthew Brenner

Nature Chemical Biology 13, 131 (2017). doi:10.1038/nchembio.2290

Authors: Matthew Brenner, Jang Hwan Cho & Wilson W Wong

Sensing and responding to diverse extracellular signals is a crucial aspect of cellular decision-making that is currently lacking in the synthetic biology toolkit. The development of modular receptor platforms allows for the rewiring of cellular input–output relationships.