A hybrid polyketide–nonribosomal peptide in nematodes that promotes larval survival

August 8th, 2016 by Qingyao Shou

Nature Chemical Biology 12, 770 (2016). doi:10.1038/nchembio.2144

Authors: Qingyao Shou, Likui Feng, Yaoling Long, Jungsoo Han, Joshawna K Nunnery, David H Powell & Rebecca A Butcher

Polyketides and nonribosomal peptides are two important types of natural products that are produced by many species of bacteria and fungi but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide–nonribosomal peptide from Caenorhabditis elegans that is produced in the canal-associated neurons (CANs) and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A hybrid polyketide–nonribosomal peptide in nematodes that promotes larval survival

FRET binding antenna reports spatiotemporal dynamics of GDI–Cdc42 GTPase interactions

August 8th, 2016 by Louis Hodgson

Nature Chemical Biology 12, 802 (2016). doi:10.1038/nchembio.2145

Authors: Louis Hodgson, Désirée Spiering, Mohsen Sabouri-Ghomi, Onur Dagliyan, Céline DerMardirossian, Gaudenz Danuser & Klaus M Hahn

  • Posted in Nat Chem Biol, Publications
  • Comments Off on FRET binding antenna reports spatiotemporal dynamics of GDI–Cdc42 GTPase interactions

Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer

August 8th, 2016 by Julie A Pollock

Nature Chemical Biology 12, 795 (2016). doi:10.1038/nchembio.2131

Authors: Julie A Pollock, Suzanne E Wardell, Alexander A Parent, David B Stagg, Stephanie J Ellison, Holly M Alley, Christina A Chao, Scott A Lawrence, James P Stice, Ivan Spasojevic, Jennifer G Baker, Sung Hoon Kim, Donald P McDonnell, John A Katzenellenbogen & John D Norris

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer

Enhanced Nitrite Reductase Activity and Its Correlation with Oxygen Affinity in Hemoglobin Bis-Tetramers

August 5th, 2016 by Aizhou Wang and Ronald Kluger

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.6b00542

Fluorescence-Activated Cell Sorting of Human l-asparaginase Mutant Libraries for Detecting Enzyme Variants with Enhanced Activity

August 1st, 2016 by Christos S. Karamitros and Manfred Konrad

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.6b00283
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Fluorescence-Activated Cell Sorting of Human l-asparaginase Mutant Libraries for Detecting Enzyme Variants with Enhanced Activity

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

August 1st, 2016 by Aaron Boudreau

Nature Chemical Biology 12, 779 (2016). doi:10.1038/nchembio.2143

Authors: Aaron Boudreau, Hans E Purkey, Anna Hitz, Kirk Robarge, David Peterson, Sharada Labadie, Mandy Kwong, Rebecca Hong, Min Gao, Christopher Del Nagro, Raju Pusapati, Shuguang Ma, Laurent Salphati, Jodie Pang, Aihe Zhou, Tommy Lai, Yingjie Li, Zhongguo Chen, Binqing Wei, Ivana Yen, Steve Sideris, Mark McCleland, Ron Firestein, Laura Corson, Alex Vanderbilt, Simon Williams, Anneleen Daemen, Marcia Belvin, Charles Eigenbrot, Peter K Jackson, Shiva Malek, Georgia Hatzivassiliou, Deepak Sampath, Marie Evangelista & Thomas O'Brien

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

An histidine covalent receptor and butenolide complex mediates strigolactone perception

August 1st, 2016 by Alexandre de Saint Germain

Nature Chemical Biology 12, 787 (2016). doi:10.1038/nchembio.2147

Authors: Alexandre de Saint Germain, Guillaume Clavé, Marie-Ange Badet-Denisot, Jean-Paul Pillot, David Cornu, Jean-Pierre Le Caer, Marco Burger, Frank Pelissier, Pascal Retailleau, Colin Turnbull, Sandrine Bonhomme, Joanne Chory, Catherine Rameau & François-Didier Boyer

  • Posted in Nat Chem Biol, Publications
  • Comments Off on An histidine covalent receptor and butenolide complex mediates strigolactone perception

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

July 25th, 2016 by Yasuyuki Miyake

Nature Chemical Biology 12, 748 (2016). doi:10.1038/nchembio.2140

Authors: Yasuyuki Miyake, Jeremy J Keusch, Longlong Wang, Makoto Saito, Daniel Hess, Xiaoning Wang, Bruce J Melancon, Paul Helquist, Heinz Gut & Patrick Matthias

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

Photoswitchable diacylglycerols enable optical control of protein kinase C

July 25th, 2016 by James Allen Frank

Nature Chemical Biology 12, 755 (2016). doi:10.1038/nchembio.2141

Authors: James Allen Frank, Dmytro A Yushchenko, David J Hodson, Noa Lipstein, Jatin Nagpal, Guy A Rutter, Jeong-Seop Rhee, Alexander Gottschalk, Nils Brose, Carsten Schultz & Dirk Trauner

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Photoswitchable diacylglycerols enable optical control of protein kinase C

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

July 25th, 2016 by Yang Hai

Nature Chemical Biology 12, 741 (2016). doi:10.1038/nchembio.2134

Authors: Yang Hai & David W Christianson

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Histone deacetylase 6 structure and molecular basis of catalysis and inhibition