Neurodegenerative disease: Not stuck on repeat

July 18th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2444

Author: Mirella Bucci

Redox regulation: Scaffolding H2O2 signaling

July 18th, 2017 by Hadley D Sikes

Nature Chemical Biology 13, 818 (2017). doi:10.1038/nchembio.2432

Author: Hadley D Sikes

Peroxidases, rather than simply reducing H2O2 to water, also convey oxidation signals to proteins such as transcription factors. A new study reveals how a scaffold protein enables formation of a mixed disulfide between the peroxidase and a transcription factor.

An excited state underlies gene regulation of a transcriptional riboswitch

July 17th, 2017 by Bo Zhao

Nature Chemical Biology 13, 968 (2017). doi:10.1038/nchembio.2427

Authors: Bo Zhao, Sharon L Guffy, Benfeard Williams & Qi Zhang

  • Posted in Nat Chem Biol, Publications
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Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

July 17th, 2017 by Deepankar Gahloth

Nature Chemical Biology 13, 975 (2017). doi:10.1038/nchembio.2434

Authors: Deepankar Gahloth, Mark S Dunstan, Daniela Quaglia, Evaldas Klumbys, Michael P Lockhart-Cairns, Andrew M Hill, Sasha R Derrington, Nigel S Scrutton, Nicholas J Turner & David Leys

  • Posted in Nat Chem Biol, Publications
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Developing a Genetically Encoded, Cross-Species Biosensor for Detecting Ammonium and Regulating Biosynthesis of Cyanophycin

July 13th, 2017 by Yi Xiao, Wen Jiang and Fuzhong Zhang

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00069
  • Posted in ACS Synthetic Biology, Publications
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Allosteric sensitization of proapoptotic BAX

July 10th, 2017 by Jonathan R Pritz

Nature Chemical Biology 13, 961 (2017). doi:10.1038/nchembio.2433

Authors: Jonathan R Pritz, Franziska Wachter, Susan Lee, James Luccarelli, Thomas E Wales, Daniel T Cohen, Paul Coote, Gregory J Heffron, John R Engen, Walter Massefski & Loren D Walensky

The structure of vanadium nitrogenase reveals an unusual bridging ligand

July 10th, 2017 by Daniel Sippel

Nature Chemical Biology 13, 956 (2017). doi:10.1038/nchembio.2428

Authors: Daniel Sippel & Oliver Einsle

  • Posted in Nat Chem Biol, Publications
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A molecular rheostat maintains ATP levels to drive a synthetic biochemistry system

July 3rd, 2017 by Paul H Opgenorth

Nature Chemical Biology 13, 938 (2017). doi:10.1038/nchembio.2418

Authors: Paul H Opgenorth, Tyler P Korman, Liviu Iancu & James U Bowie

  • Posted in Nat Chem Biol, Publications
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Extracellular vesicles are independent metabolic units with asparaginase activity

July 3rd, 2017 by Nunzio Iraci

Nature Chemical Biology 13, 951 (2017). doi:10.1038/nchembio.2422

Authors: Nunzio Iraci, Edoardo Gaude, Tommaso Leonardi, Ana S H Costa, Chiara Cossetti, Luca Peruzzotti-Jametti, Joshua D Bernstock, Harpreet K Saini, Maurizio Gelati, Angelo Luigi Vescovi, Carlos Bastos, Nuno Faria, Luigi G Occhipinti, Anton J Enright, Christian Frezza & Stefano Pluchino

  • Posted in Nat Chem Biol, Publications
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A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase

July 3rd, 2017 by Samantha Wellington

Nature Chemical Biology 13, 943 (2017). doi:10.1038/nchembio.2420

Authors: Samantha Wellington, Partha P Nag, Karolina Michalska, Stephen E Johnston, Robert P Jedrzejczak, Virendar K Kaushik, Anne E Clatworthy, Noman Siddiqi, Patrick McCarren, Besnik Bajrami, Natalia I Maltseva, Senya Combs, Stewart L Fisher, Andrzej Joachimiak, Stuart L Schreiber & Deborah T Hung

  • Posted in Nat Chem Biol, Publications
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