Bioorthogonal chemistry: Click on, click off

September 19th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2482

Author: Caitlin Deane

Developmental signaling: Peaking early

September 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2484

Author: Grant Miura

Target class drug discovery

September 19th, 2017 by Kimberly D Barnash

Nature Chemical Biology 13, 1053 (2017). doi:10.1038/nchembio.2473

Authors: Kimberly D Barnash, Lindsey I James & Stephen V Frye

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complimentary approach that has higher quality outcomes in early discovery efforts.

Detecting Activity at Different Length Scales: From Subdiffraction to Whole-Animal Activity

September 15th, 2017 by Tsz-Leung To and Xiaokun Shu

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.7b00788

A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase

September 8th, 2017 by Eric P. Trautman and Jason M. Crawford

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.7b00680

Ionic Strength Sensing in Living Cells

September 6th, 2017 by Boqun Liu, Bert Poolman and Arnold J. Boersma

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.7b00348

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8

August 30th, 2017 by Nicholas J. Porter and David W. Christianson

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.7b00330

Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel

August 28th, 2017 by Mikhail Metelev

Nature Chemical Biology 13, 1129 (2017). doi:10.1038/nchembio.2462

Authors: Mikhail Metelev, Ilya A Osterman, Dmitry Ghilarov, Nelli F Khabibullina, Alexander Yakimov, Konstantin Shabalin, Irina Utkina, Dmitry Y Travin, Ekaterina S Komarova, Marina Serebryakova, Tatyana Artamonova, Mikhail Khodorkovskii, Andrey L Konevega, Petr V Sergiev, Konstantin Severinov & Yury S Polikanov

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel

Oxidative cleavage of polysaccharides by monocopper enzymes depends on H2O2

August 28th, 2017 by Bastien Bissaro

Nature Chemical Biology 13, 1123 (2017). doi:10.1038/nchembio.2470

Authors: Bastien Bissaro, Åsmund K Røhr, Gerdt Müller, Piotr Chylenski, Morten Skaugen, Zarah Forsberg, Svein J Horn, Gustav Vaaje-Kolstad & Vincent G H Eijsink

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Oxidative cleavage of polysaccharides by monocopper enzymes depends on H2O2

Staphylococcus aureus CidC Is a Pyruvate:Menaquinone Oxidoreductase

August 25th, 2017 by Xinyan Zhang, Kenneth W. Bayles and Sorin Luca

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.7b00570