Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence

December 19th, 2016 by Huiqing Zheng

Nature Chemical Biology 13, 218 (2017). doi:10.1038/nchembio.2259

Authors: Huiqing Zheng, Christopher J Colvin, Benjamin K Johnson, Paul D Kirchhoff, Michael Wilson, Katriana Jorgensen-Muga, Scott D Larsen & Robert B Abramovitch

  • Posted in Nat Chem Biol, Publications
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Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

December 19th, 2016 by Tony Ngo

Nature Chemical Biology 13, 235 (2017). doi:10.1038/nchembio.2266

Authors: Tony Ngo, Andrey V Ilatovskiy, Alastair G Stewart, James L J Coleman, Fiona M McRobb, R Peter Riek, Robert M Graham, Ruben Abagyan, Irina Kufareva & Nicola J Smith

  • Posted in Nat Chem Biol, Publications
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Protein folding: Minimizing frustration

December 16th, 2016 by Mirella Bucci

Nature Chemical Biology 13, 1 (2017). doi:10.1038/nchembio.2277

Author: Mirella Bucci

Biocatalysis: Custom carbon cycling

December 16th, 2016 by Caitlin Deane

Nature Chemical Biology 13, 1 (2017). doi:10.1038/nchembio.2275

Author: Caitlin Deane

Neurodegeneration: Untangling tau

December 16th, 2016 by Alison Farrell

Nature Chemical Biology 13, 1 (2017). doi:10.1038/nchembio.2276

Author: Alison Farrell

RNA structure: Widening the probe

December 16th, 2016 by Grant Miura

Nature Chemical Biology 13, 1 (2017). doi:10.1038/nchembio.2274

Author: Grant Miura

Natural products: Mapping an amazing thicket

December 16th, 2016 by Mark E Horsman

Nature Chemical Biology 13, 6 (2017). doi:10.1038/nchembio.2265

Authors: Mark E Horsman & Christopher N Boddy

The Global Natural Products Social Molecular Networking (GNPS) resource and the DEREPLICATOR algorithm provide new tools for analyzing mass spectral data and enabling natural products discovery.

RAS signaling: Divide and conquer

December 16th, 2016 by Matthew Holderfield

Nature Chemical Biology 13, 7 (2017). doi:10.1038/nchembio.2264

Authors: Matthew Holderfield & Deborah K Morrison

The role of RAS dimerization in tumor biology is an emerging area of preclinical cancer research. Characterization of a RAS monobody indicates that dimer formation is required for RAS signaling, revealing the dimer interface as a potential drug target.

Single-molecule analysis reveals multi-state folding of a guanine riboswitch

December 12th, 2016 by Vishnu Chandra

Nature Chemical Biology 13, 194 (2017). doi:10.1038/nchembio.2252

Authors: Vishnu Chandra, Zain Hannan, Huizhong Xu & Maumita Mandal

  • Posted in Nat Chem Biol, Publications
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Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

December 12th, 2016 by Ruchi Jain Dey

Nature Chemical Biology 13, 210 (2017). doi:10.1038/nchembio.2254

Authors: Ruchi Jain Dey, Bappaditya Dey, Yue Zheng, Laurene S Cheung, Jie Zhou, David Sayre, Pankaj Kumar, Haidan Guo, Gyanu Lamichhane, Herman O Sintim & William R Bishai

  • Posted in Nat Chem Biol, Publications
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