Neurodegeneration: Untangling tau

December 16th, 2016 by Alison Farrell

Nature Chemical Biology 13, 1 (2017). doi:10.1038/nchembio.2276

Author: Alison Farrell

RNA structure: Widening the probe

December 16th, 2016 by Grant Miura

Nature Chemical Biology 13, 1 (2017). doi:10.1038/nchembio.2274

Author: Grant Miura

Natural products: Mapping an amazing thicket

December 16th, 2016 by Mark E Horsman

Nature Chemical Biology 13, 6 (2017). doi:10.1038/nchembio.2265

Authors: Mark E Horsman & Christopher N Boddy

The Global Natural Products Social Molecular Networking (GNPS) resource and the DEREPLICATOR algorithm provide new tools for analyzing mass spectral data and enabling natural products discovery.

RAS signaling: Divide and conquer

December 16th, 2016 by Matthew Holderfield

Nature Chemical Biology 13, 7 (2017). doi:10.1038/nchembio.2264

Authors: Matthew Holderfield & Deborah K Morrison

The role of RAS dimerization in tumor biology is an emerging area of preclinical cancer research. Characterization of a RAS monobody indicates that dimer formation is required for RAS signaling, revealing the dimer interface as a potential drug target.

Precise small-molecule recognition of a toxic CUG RNA repeat expansion

December 12th, 2016 by Suzanne G Rzuczek

Nature Chemical Biology 13, 188 (2017). doi:10.1038/nchembio.2251

Authors: Suzanne G Rzuczek, Lesley A Colgan, Yoshio Nakai, Michael D Cameron, Denis Furling, Ryohei Yasuda & Matthew D Disney

  • Posted in Nat Chem Biol, Publications
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Rewiring human cellular input–output using modular extracellular sensors

December 12th, 2016 by Kelly A Schwarz

Nature Chemical Biology 13, 202 (2017). doi:10.1038/nchembio.2253

Authors: Kelly A Schwarz, Nichole M Daringer, Taylor B Dolberg & Joshua N Leonard

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Rewiring human cellular input–output using modular extracellular sensors

Single-molecule analysis reveals multi-state folding of a guanine riboswitch

December 12th, 2016 by Vishnu Chandra

Nature Chemical Biology 13, 194 (2017). doi:10.1038/nchembio.2252

Authors: Vishnu Chandra, Zain Hannan, Huizhong Xu & Maumita Mandal

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Single-molecule analysis reveals multi-state folding of a guanine riboswitch

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

December 12th, 2016 by Ruchi Jain Dey

Nature Chemical Biology 13, 210 (2017). doi:10.1038/nchembio.2254

Authors: Ruchi Jain Dey, Bappaditya Dey, Yue Zheng, Laurene S Cheung, Jie Zhou, David Sayre, Pankaj Kumar, Haidan Guo, Gyanu Lamichhane, Herman O Sintim & William R Bishai

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

A Comparison between the Photoactivation Kinetics of Human and Bovine Rhodopsins

December 9th, 2016 by Chie Funatogawa, Istvan Szundi and David S. Kliger

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.6b00953

Sequential and Coupled Proton and Electron Transfer Events in the S2 → S3 Transition of Photosynthetic Water Oxidation Revealed by Time-Resolved X-ray Absorption Spectroscopy

December 5th, 2016 by Ivelina Zaharieva, Holger Dau and Michael Haumann

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.6b01078