Resistance to nonribosomal peptide antibiotics mediated by <span class=”small-caps”>d</span>-stereospecific peptidases
February 26th, 2018 by Yong-Xin Li
Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases
Resistance to nonribosomal peptide antibiotics mediated by <span class="small-caps">d</span>-stereospecific peptidases, Published online: 26 February 2018; doi:10.1038/s41589-018-0009-4
Networking-associated genome mining on bacterial genomes followed by chemical and enzymatic analysis identified a mechanism of resistance toward nonribosomal peptide antibiotics based on hydrolytic cleavage by d-stereospecific peptidases.A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
February 26th, 2018 by Kiryl D. Piatkevich
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Published online: 26 February 2018; doi:10.1038/s41589-018-0004-9
Directed evolution of opsins via robotic high-content screening finds a fluorescent reporter of voltage that is simultaneously optimized for brightness, localization and voltage sensitivity and is applicable in three model systems.Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques
February 23rd, 2018 by Sébastien Alphonse, Boris Itin, Reza Khayat and Ranajeet Ghose
Protein Plasticity and Peptide Editing in the MHC I Antigen Processing Pathway
February 22nd, 2018 by Tim Elliott and Andy van Hateren
Orthogonal Information Encoding in Living Cells with High Error-Tolerance, Safety, and Fidelity
February 21st, 2018 by Lifu Song and An-Ping Zeng
More Than a Light Switch: Engineering Unconventional Fluorescent Configurations for Biological Sensing
February 20th, 2018 by William J. Peveler and W. Russ Algar
Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases
February 19th, 2018 by Lukas Reisky
Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases
Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases, Published online: 19 February 2018; doi:10.1038/s41589-018-0005-8
The discovery of cytochrome P450 monooxygenases that catalyze oxidative demethylation of 6-O-methyl-d-galactose reveals a new activity of cytochrome P450 enzymes and their role in polysaccharide biomass degradation in marine bacteria.How many human proteoforms are there?
February 14th, 2018 by Ruedi Aebersold
How many human proteoforms are there?
How many human proteoforms are there?, Published online: 14 February 2018; doi:10.1038/nchembio.2576
How many human proteoforms are there?Insights into the biogenesis, function, and regulation of ADP-ribosylation
February 14th, 2018 by Michael S Cohen
Insights into the biogenesis, function, and regulation of ADP-ribosylation
Insights into the biogenesis, function, and regulation of ADP-ribosylation, Published online: 14 February 2018; doi:10.1038/nchembio.2568
Insights into the biogenesis, function, and regulation of ADP-ribosylationRNA structure: A LASER-focused view into cells
February 14th, 2018 by Philip C Bevilacqua
RNA structure: A LASER-focused view into cells
RNA structure: A LASER-focused view into cells, Published online: 14 February 2018; doi:10.1038/nchembio.2570
RNA structure is irrevocably linked to function. A new method, termed 'LASER', utilizes a light-activated chemical probe to query RNA tertiary structure and illuminate RNA–protein interactions in the living cell.