Selective in vivo metabolic cell-labeling-mediated cancer targeting

February 13th, 2017 by Hua Wang

Nature Chemical Biology 13, 415 (2017). doi:10.1038/nchembio.2297

Authors: Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen, Lichen Yin & Jianjun Cheng

CipA and CipB as Scaffolds To Organize Proteins into Crystalline Inclusions

February 10th, 2017 by Yang Wang, Ralf Heermann and Kirsten Jung

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.6b00323

In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins

February 6th, 2017 by Kaitlin Schaefer

Nature Chemical Biology 13, 396 (2017). doi:10.1038/nchembio.2302

Authors: Kaitlin Schaefer, Leigh M Matano, Yuan Qiao, Daniel Kahne & Suzanne Walker

  • Posted in Nat Chem Biol, Publications
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A water-mediated allosteric network governs activation of Aurora kinase A

February 6th, 2017 by Soreen Cyphers

Nature Chemical Biology 13, 402 (2017). doi:10.1038/nchembio.2296

Authors: Soreen Cyphers, Emily F Ruff, Julie M Behr, John D Chodera & Nicholas M Levinson

  • Posted in Nat Chem Biol, Publications
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A tight tunable range for Ni(II) sensing and buffering in cells

February 6th, 2017 by Andrew W Foster

Nature Chemical Biology 13, 409 (2017). doi:10.1038/nchembio.2310

Authors: Andrew W Foster, Rafael Pernil, Carl J Patterson, Andrew J P Scott, Lars-Olof Pålsson, Robert Pal, Ian Cummins, Peter T Chivers, Ehmke Pohl & Nigel J Robinson

Structure and specificity of a permissive bacterial C-prenyltransferase

February 6th, 2017 by Sherif I Elshahawi

Nature Chemical Biology 13, 366 (2017). doi:10.1038/nchembio.2285

Authors: Sherif I Elshahawi, Hongnan Cao, Khaled A Shaaban, Larissa V Ponomareva, Thangaiah Subramanian, Mark L Farman, H Peter Spielmann, George N Phillips, Jon S Thorson & Shanteri Singh

This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.

  • Posted in Nat Chem Biol, Publications
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation

January 30th, 2017 by Pauline Scholler

Nature Chemical Biology 13, 372 (2017). doi:10.1038/nchembio.2286

Authors: Pauline Scholler, David Moreno-Delgado, Nathalie Lecat-Guillet, Etienne Doumazane, Carine Monnier, Fabienne Charrier-Savournin, Ludovic Fabre, Cédric Chouvet, Stéphanie Soldevila, Laurent Lamarque, Geoffrey Donsimoni, Thomas Roux, Jurriaan M Zwier, Eric Trinquet, Philippe Rondard & Jean-Philippe Pin

  • Posted in Nat Chem Biol, Publications
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The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

January 30th, 2017 by Yupeng He

Nature Chemical Biology 13, 389 (2017). doi:10.1038/nchembio.2306

Authors: Yupeng He, Sujatha Selvaraju, Michael L Curtin, Clarissa G Jakob, Haizhong Zhu, Kenneth M Comess, Bailin Shaw, Juliana The, Evelyne Lima-Fernandes, Magdalena M Szewczyk, Dong Cheng, Kelly L Klinge, Huan-Qiu Li, Marina Pliushchev, Mikkel A Algire, David Maag, Jun Guo, Justin Dietrich, Sanjay C Panchal, Andrew M Petros, Ramzi F Sweis, Maricel Torrent, Lance J Bigelow, Guillermo Senisterra, Fengling Li, Steven Kennedy, Qin Wu, Donald J Osterling, David J Lindley, Wenqing Gao, Scott Galasinski, Dalia Barsyte-Lovejoy, Masoud Vedadi, Fritz G Buchanan, Cheryl H Arrowsmith, Gary G Chiang, Chaohong Sun & William N Pappano

  • Posted in Nat Chem Biol, Publications
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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

January 30th, 2017 by Wei Qi

Nature Chemical Biology 13, 381 (2017). doi:10.1038/nchembio.2304

Authors: Wei Qi, Kehao Zhao, Justin Gu, Ying Huang, Youzhen Wang, Hailong Zhang, Man Zhang, Jeff Zhang, Zhengtian Yu, Ling Li, Lin Teng, Shannon Chuai, Chao Zhang, Mengxi Zhao, HoMan Chan, Zijun Chen, Douglas Fang, Qi Fei, Leying Feng, Lijian Feng, Yuan Gao, Hui Ge, Xinjian Ge, Guobin Li, Andreas Lingel, Ying Lin, Yueqin Liu, Fangjun Luo, Minlong Shi, Long Wang, Zhaofu Wang, Yanyan Yu, Jue Zeng, Chenhui Zeng, Lijun Zhang, Qiong Zhang, Shaolian Zhou, Counde Oyang, Peter Atadja & En Li

  • Posted in Nat Chem Biol, Publications
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Chromatin biology: Breaking into the PRC2 cage

January 30th, 2017 by Daniel Holoch

Nature Chemical Biology 13, 345 (2017). doi:10.1038/nchembio.2313

Authors: Daniel Holoch & Raphaël Margueron

New small-molecule inhibitors of the histone methyltransferase PRC2 interfere with the allosteric activation of enzymatic activity. These compounds are effective against PRC2-dependent tumors that are resistant to catalytic inhibitors and provide important new tools for altering chromatin regulation.