Trp-ing upon new repressors

February 26th, 2018 by Andreas K. Brödel

Trp-ing upon new repressors

Trp-ing upon new repressors, Published online: 26 February 2018; doi:10.1038/s41589-018-0012-9

Bioengineers have used directed evolution to generate a new family of synthetic transcription factors based on the tryptophan repressor. The evolved repressor family enables researchers to build new gene circuits for biomedical applications.

Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques

February 23rd, 2018 by Sébastien Alphonse, Boris Itin, Reza Khayat and Ranajeet Ghose

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Biochemistry
DOI: 10.1021/acs.biochem.8b00003

Protein Plasticity and Peptide Editing in the MHC I Antigen Processing Pathway

February 22nd, 2018 by Tim Elliott and Andy van Hateren

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Biochemistry
DOI: 10.1021/acs.biochem.7b01307

Orthogonal Information Encoding in Living Cells with High Error-Tolerance, Safety, and Fidelity

February 21st, 2018 by Lifu Song and An-Ping Zeng

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00382

More Than a Light Switch: Engineering Unconventional Fluorescent Configurations for Biological Sensing

February 20th, 2018 by William J. Peveler and W. Russ Algar

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b01022
  • Posted in ACS Chemical Biology, Publications
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Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

February 19th, 2018 by Lukas Reisky

Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases, Published online: 19 February 2018; doi:10.1038/s41589-018-0005-8

The discovery of cytochrome P450 monooxygenases that catalyze oxidative demethylation of 6-O-methyl-d-galactose reveals a new activity of cytochrome P450 enzymes and their role in polysaccharide biomass degradation in marine bacteria.
  • Posted in Nat Chem Biol, Publications
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RNA structure: A LASER-focused view into cells

February 14th, 2018 by Philip C Bevilacqua

RNA structure: A LASER-focused view into cells

RNA structure: A LASER-focused view into cells, Published online: 14 February 2018; doi:10.1038/nchembio.2570

RNA structure is irrevocably linked to function. A new method, termed 'LASER', utilizes a light-activated chemical probe to query RNA tertiary structure and illuminate RNA–protein interactions in the living cell.

The ABCs of PTMs

February 14th, 2018 by Karl W Barber

The ABCs of PTMs

The ABCs of PTMs, Published online: 14 February 2018; doi:10.1038/nchembio.2572

Post-translational modifications (PTMs) are ubiquitous in all forms of life and often modulate critical protein functions. Recent chemical and biological advances have finally enabled scientists to precisely modify proteins at physiologically relevant positions, ushering in a new era of protein studies.

Ubiquitination: Trashing the CIA

February 14th, 2018 by Grant Miura

Ubiquitination: Trashing the CIA

Ubiquitination: Trashing the CIA, Published online: 14 February 2018; doi:10.1038/nchembio.2580

Ubiquitination: Trashing the CIA

Protein evolution: Hacking an enzyme

February 14th, 2018 by Kristoffer E Johansson

Protein evolution: Hacking an enzyme

Protein evolution: Hacking an enzyme, Published online: 14 February 2018; doi:10.1038/nchembio.2574

Early stages of protein evolution are inherently difficult to study. Genetic selection in Escherichia coli has now identified a life-sustaining de novo enzyme arising from a simple scaffold that is completely different from the native enzyme.