Synthetic biology: Synthetic gene networks that smell

February 15th, 2017 by Fahim Farzadfard

Nature Chemical Biology 13, 245 (2017). doi:10.1038/nchembio.2315

Authors: Fahim Farzadfard & Timothy K Lu

Bioengineers have endowed a consortium of human cells with an artificial sense of smell, enabling the cells to detect, quantify, and remember the presence of gaseous volatile compounds in their environment.

Enzyme mechanisms: Fickle about fluorine

February 15th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 243 (2017). doi:10.1038/nchembio.2324

Author: Caitlin Deane

Plant infection: A decoy tactic

February 15th, 2017 by Grant Miura

Nature Chemical Biology 13, 243 (2017). doi:10.1038/nchembio.2322

Author: Grant Miura

Metabolism: A-way with biofilms

February 15th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 243 (2017). doi:10.1038/nchembio.2325

Author: Mirella Bucci

G-Protein-coupled receptors: Decoding mixed signals

February 15th, 2017 by Thomas J Gardella

Nature Chemical Biology 13, 247 (2017). doi:10.1038/nchembio.2316

Author: Thomas J Gardella

A new mechanism of functional crosstalk between two distinct G-protein-coupled receptors (GPCRs)—the parathyroid hormone receptor (PTHR) and β2-adrenergic receptor (β2 Ar)—that occurs at the level of G protein βγ subunits and a specific adenylyl cyclase isoform is identified. This crosstalk augments cAMP signaling by the PTHR from endosomes, and thus promotes the actions of PTH ligands in bone target cells.

Accelerating the semisynthesis of alkaloid-based drugs through metabolic engineering

February 15th, 2017 by Amy M Ehrenworth

Nature Chemical Biology 13, 249 (2017). doi:10.1038/nchembio.2308

Authors: Amy M Ehrenworth & Pamela Peralta-Yahya

  • Posted in Nat Chem Biol, Publications
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Selective in vivo metabolic cell-labeling-mediated cancer targeting

February 13th, 2017 by Hua Wang

Nature Chemical Biology 13, 415 (2017). doi:10.1038/nchembio.2297

Authors: Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen, Lichen Yin & Jianjun Cheng

AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons

February 13th, 2017 by Kirill Gorshkov

Nature Chemical Biology 13, 425 (2017). doi:10.1038/nchembio.2298

Authors: Kirill Gorshkov, Sohum Mehta, Santosh Ramamurthy, Gabriele V Ronnett, Feng-Quan Zhou & Jin Zhang

  • Posted in Nat Chem Biol, Publications
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An orthogonalized platform for genetic code expansion in both bacteria and eukaryotes

February 13th, 2017 by James S Italia

Nature Chemical Biology 13, 446 (2017). doi:10.1038/nchembio.2312

Authors: James S Italia, Partha Sarathi Addy, Chester J J Wrobel, Lisa A Crawford, Marc J Lajoie, Yunan Zheng & Abhishek Chatterjee

  • Posted in Nat Chem Biol, Publications
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Evolution of a split RNA polymerase as a versatile biosensor platform

February 13th, 2017 by Jinyue Pu

Nature Chemical Biology 13, 432 (2017). doi:10.1038/nchembio.2299

Authors: Jinyue Pu, Julia Zinkus-Boltz & Bryan C Dickinson

  • Posted in Nat Chem Biol, Publications
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