Biosynthesis of an Opine Metallophore by Pseudomonas aeruginosa
November 3rd, 2017 by Jeffrey S. McFarlane and Audrey L. Lamb
Large Scale Mutational and Kinetic Analysis of a Self-Hydrolyzing Deoxyribozyme
November 3rd, 2017 by V. Dhamodharan, Shungo Kobori and Yohei Yokobayashi
Synthetic beta cells for fusion-mediated dynamic insulin secretion
October 30th, 2017 by Zhaowei Chen
Synthetic beta cells for fusion-mediated dynamic insulin secretion
Synthetic beta cells for fusion-mediated dynamic insulin secretion, Published online: 30 October 2017; doi:10.1038/nchembio.2511
NatureArticleSnippet(type=short-summary, markup=Synthetic beta cells were fabricated through 'vesicles-in-vesicle' liposomal superstructures equipped with glucose-sensing and membrane-fusion machinery, thus enabling sensing of graded glucose levels and secretion of insulin via fusion processes.
PatB1 is an <i>O</i>-acetyltransferase that decorates secondary cell wall polysaccharides
October 30th, 2017 by David Sychantha
PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides
PatB1 is an <i>O</i>-acetyltransferase that decorates secondary cell wall polysaccharides, Published online: 30 October 2017; doi:10.1038/nchembio.2509
NatureArticleSnippet(type=short-summary, markup=A chemically synthesized analog of
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer
October 30th, 2017 by Yi Qu
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer, Published online: 30 October 2017; doi:10.1038/nchembio.2510
NatureArticleSnippet(type=short-summary, markup=The small molecule nitazoxanide (NTZ) was identified as a Wnt inhibitor by promoting protein citrullination of β-catenin through increased cytosolic calcium and PAD2 protein stabilization. β-catenin citrullination results in proteasomal degradation.
The Conformational Change in Elongation Factor Tu Involves Separation of Its Domains
October 27th, 2017 by Jonathan Lai, Zhaleh Ghaemi and Zaida Luthey-Schulten
Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations
October 27th, 2017 by Srinivasaraghavan Kannan, Anders Poulsen, Hai Yan Yang, Melvyn Ho, Shi Hua Ang, Tan Sum Wai Eldwin, Duraiswamy Athisayamani Jeyaraj, Lohitha Rao Chennamaneni, Boping Liu, Jeffrey Hill, Chandra S. Verma and Kassoum Nacro
Structural and Functional Effects of Cytochrome b5 Interactions with Human Cytochrome P450 Enzymes [Enzymology]
October 27th, 2017 by Aaron G. Bart, Emily E. Scott
The small heme-containing protein cytochrome b5 can facilitate, inhibit, or have no effect on cytochrome P450 catalysis, often in a P450-dependent and substrate-dependent manner that is not well understood. Herein solution NMR was used to identify b5 residues interacting with different human drug-metabolizing P450 enzymes. NMR results revealed that P450 enzymes bound to either b5 α4-5 (CYP2A6 and CYP2E1) or this region and α2-3 (CYP2D6 and CYP3A4) and suggested variation in the affinity for b5. Mutations of key b5 residues suggest that not only are different b5 surfaces responsible for binding different P450 enzymes, but that these different complexes are relevant to the observed effects on P450 catalysis.The G126V Mutation in the Mouse Prion Protein Hinders Nucleation-Dependent Fibril Formation by Slowing Initial Fibril Growth and by Increasing the Critical Concentration
October 26th, 2017 by Ambadi Thody Sabareesan and Jayant B. Udgaonkar
Next-Generation Photodynamic Therapy: New Probes for Cancer Imaging and Treatment
October 26th, 2017 by Andrew A. Beharry
