Hints of hidden chemistry
July 18th, 2017 by Nature Chemical Biology - Issue - nature.com science feeds
Nature Chemical Biology 13, 815 (2017). doi:10.1038/nchembio.2449
Biosynthetic pathways harbor diverse enzyme functions, and identifying those that catalyze unusual or synthetically challenging transformations offers new routes for biocatalytic development.
Biosynthesis: Methylating mushrooms
July 18th, 2017 by Albert A Bowers
Nature Chemical Biology 13, 821 (2017). doi:10.1038/nchembio.2437
Author: Albert A Bowers
The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.
Neurodegenerative disease: Not stuck on repeat
July 18th, 2017 by Mirella Bucci
Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2444
Author: Mirella Bucci
Redox regulation: Scaffolding H2O2 signaling
July 18th, 2017 by Hadley D Sikes
Nature Chemical Biology 13, 818 (2017). doi:10.1038/nchembio.2432
Author: Hadley D Sikes
Peroxidases, rather than simply reducing H2O2 to water, also convey oxidation signals to proteins such as transcription factors. A new study reveals how a scaffold protein enables formation of a mixed disulfide between the peroxidase and a transcription factor.
Enzymology: Tracking off-targets
July 18th, 2017 by Alison Farrell
Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2445
Author: Alison Farrell
Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
July 18th, 2017 by Yupeng He
Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922b
Author: Yupeng He, Sujatha Selvaraju, Michael L Curtin, Clarissa G Jakob, Haizhong Zhu, Kenneth M Comess, Bailin Shaw, Juliana The, Evelyne Lima-Fernandes, Magdalena M Szewczyk, Dong Cheng, Kelly L Klinge, Huan-Qiu Li, Marina Pliushchev, Mikkel A Algire, David Maag, Jun Guo, Justin Dietrich, Sanjay C Panchal, Andrew M Petros, Ramzi F Sweis, Maricel Torrent, Lance J Bigelow, Guillermo Senisterra, Fengling Li, Steven Kennedy, Qin Wu, Donald J Osterling, David J Lindley, Wenqing Gao, Scott Galasinski, Dalia Barsyte-Lovejoy, Masoud Vedadi, Fritz G Buchanan, Cheryl H Arrowsmith, Gary G Chiang, Chaohong Sun & William N Pappano
Antibacterials: PUMmeling RNAP
July 18th, 2017 by Terry L. Sheppard
Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2446
Author: Terry L. Sheppard
Erratum: Structural and conformational determinants of macrocycle cell permeability
July 18th, 2017 by Björn Over
Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922a
Author: Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall & Jan Kihlberg
Biocatalysis: Achieving aminase activity
July 18th, 2017 by Caitlin Deane
Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2447
Author: Caitlin Deane
Harnessing yeast organelles for metabolic engineering
July 18th, 2017 by Sarah K Hammer
Nature Chemical Biology 13, 823 (2017). doi:10.1038/nchembio.2429
Authors: Sarah K Hammer & José L Avalos