A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase

July 3rd, 2017 by Samantha Wellington

Nature Chemical Biology 13, 943 (2017). doi:10.1038/nchembio.2420

Authors: Samantha Wellington, Partha P Nag, Karolina Michalska, Stephen E Johnston, Robert P Jedrzejczak, Virendar K Kaushik, Anne E Clatworthy, Noman Siddiqi, Patrick McCarren, Besnik Bajrami, Natalia I Maltseva, Senya Combs, Stewart L Fisher, Andrzej Joachimiak, Stuart L Schreiber & Deborah T Hung

  • Posted in Nat Chem Biol, Publications
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A molecular rheostat maintains ATP levels to drive a synthetic biochemistry system

July 3rd, 2017 by Paul H Opgenorth

Nature Chemical Biology 13, 938 (2017). doi:10.1038/nchembio.2418

Authors: Paul H Opgenorth, Tyler P Korman, Liviu Iancu & James U Bowie

  • Posted in Nat Chem Biol, Publications
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Extracellular vesicles are independent metabolic units with asparaginase activity

July 3rd, 2017 by Nunzio Iraci

Nature Chemical Biology 13, 951 (2017). doi:10.1038/nchembio.2422

Authors: Nunzio Iraci, Edoardo Gaude, Tommaso Leonardi, Ana S H Costa, Chiara Cossetti, Luca Peruzzotti-Jametti, Joshua D Bernstock, Harpreet K Saini, Maurizio Gelati, Angelo Luigi Vescovi, Carlos Bastos, Nuno Faria, Luigi G Occhipinti, Anton J Enright, Christian Frezza & Stefano Pluchino

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CAGE: Chromatin Analogous Gene Expression

June 30th, 2017 by Reza M. Zadegan and William L. Hughes

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00045

Monitoring thioredoxin redox with a genetically encoded red fluorescent biosensor

June 26th, 2017 by Yichong Fan

Nature Chemical Biology 13, 1045 (2017). doi:10.1038/nchembio.2417

Authors: Yichong Fan, Merna Makar, Michael X Wang & Hui-wang Ai

  • Posted in Nat Chem Biol, Publications
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Molecular basis of the evolution of alternative tyrosine biosynthetic routes in plants

June 26th, 2017 by Craig A Schenck

Nature Chemical Biology 13, 1029 (2017). doi:10.1038/nchembio.2414

Authors: Craig A Schenck, Cynthia K Holland, Matthew R Schneider, Yusen Men, Soon Goo Lee, Joseph M Jez & Hiroshi A Maeda

  • Posted in Nat Chem Biol, Publications
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2′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonist

June 26th, 2017 by Ralf Fliegert

Nature Chemical Biology 13, 1036 (2017). doi:10.1038/nchembio.2415

Authors: Ralf Fliegert, Andreas Bauche, Adriana-Michelle Wolf Pérez, Joanna M Watt, Monika D Rozewitz, Riekje Winzer, Mareike Janus, Feng Gu, Annette Rosche, Angelika Harneit, Marianne Flato, Christelle Moreau, Tanja Kirchberger, Valerie Wolters, Barry V L Potter & Andreas H Guse

  • Posted in Nat Chem Biol, Publications
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A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis

June 26th, 2017 by Hitomi Nakamura

Nature Chemical Biology 13, 916 (2017). doi:10.1038/nchembio.2421

Authors: Hitomi Nakamura, Erica E Schultz & Emily P Balskus

  • Posted in Nat Chem Biol, Publications
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De Novo Biosynthesis of Glutarate via α-Keto Acid Carbon Chain Extension and Decarboxylation Pathway in Escherichia coli

June 23rd, 2017 by Jian Wang, Yifei Wu, Xinxiao Sun, Qipeng Yuan and Yajun Yan

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00136
  • Posted in ACS Synthetic Biology, Publications
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Targeting the N terminus for site-selective protein modification

June 20th, 2017 by Christian B Rosen

Nature Chemical Biology 13, 697 (2017). doi:10.1038/nchembio.2416

Authors: Christian B Rosen & Matthew B Francis