Biosynthesis: Methylating mushrooms
July 18th, 2017 by Albert A Bowers
Nature Chemical Biology 13, 821 (2017). doi:10.1038/nchembio.2437
Author: Albert A Bowers
The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.
Neurodegenerative disease: Not stuck on repeat
July 18th, 2017 by Mirella Bucci
Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2444
Author: Mirella Bucci
Redox regulation: Scaffolding H2O2 signaling
July 18th, 2017 by Hadley D Sikes
Nature Chemical Biology 13, 818 (2017). doi:10.1038/nchembio.2432
Author: Hadley D Sikes
Peroxidases, rather than simply reducing H2O2 to water, also convey oxidation signals to proteins such as transcription factors. A new study reveals how a scaffold protein enables formation of a mixed disulfide between the peroxidase and a transcription factor.
Enzymology: Tracking off-targets
July 18th, 2017 by Alison Farrell
Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2445
Author: Alison Farrell
Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
July 18th, 2017 by Yupeng He
Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922b
Author: Yupeng He, Sujatha Selvaraju, Michael L Curtin, Clarissa G Jakob, Haizhong Zhu, Kenneth M Comess, Bailin Shaw, Juliana The, Evelyne Lima-Fernandes, Magdalena M Szewczyk, Dong Cheng, Kelly L Klinge, Huan-Qiu Li, Marina Pliushchev, Mikkel A Algire, David Maag, Jun Guo, Justin Dietrich, Sanjay C Panchal, Andrew M Petros, Ramzi F Sweis, Maricel Torrent, Lance J Bigelow, Guillermo Senisterra, Fengling Li, Steven Kennedy, Qin Wu, Donald J Osterling, David J Lindley, Wenqing Gao, Scott Galasinski, Dalia Barsyte-Lovejoy, Masoud Vedadi, Fritz G Buchanan, Cheryl H Arrowsmith, Gary G Chiang, Chaohong Sun & William N Pappano
An excited state underlies gene regulation of a transcriptional riboswitch
July 17th, 2017 by Bo Zhao
Nature Chemical Biology 13, 968 (2017). doi:10.1038/nchembio.2427
Authors: Bo Zhao, Sharon L Guffy, Benfeard Williams & Qi Zhang
Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis
July 17th, 2017 by Deepankar Gahloth
Nature Chemical Biology 13, 975 (2017). doi:10.1038/nchembio.2434
Authors: Deepankar Gahloth, Mark S Dunstan, Daniela Quaglia, Evaldas Klumbys, Michael P Lockhart-Cairns, Andrew M Hill, Sasha R Derrington, Nigel S Scrutton, Nicholas J Turner & David Leys
Developing a Genetically Encoded, Cross-Species Biosensor for Detecting Ammonium and Regulating Biosynthesis of Cyanophycin
July 13th, 2017 by Yi Xiao, Wen Jiang and Fuzhong Zhang
Allosteric sensitization of proapoptotic BAX
July 10th, 2017 by Jonathan R Pritz
Nature Chemical Biology 13, 961 (2017). doi:10.1038/nchembio.2433
Authors: Jonathan R Pritz, Franziska Wachter, Susan Lee, James Luccarelli, Thomas E Wales, Daniel T Cohen, Paul Coote, Gregory J Heffron, John R Engen, Walter Massefski & Loren D Walensky
The structure of vanadium nitrogenase reveals an unusual bridging ligand
July 10th, 2017 by Daniel Sippel
Nature Chemical Biology 13, 956 (2017). doi:10.1038/nchembio.2428
Authors: Daniel Sippel & Oliver Einsle