Drug discovery: Controlling protein SUMOylation

October 18th, 2017 by John S Schneekloth Jr

Drug discovery: Controlling protein SUMOylation

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2496

A potent and selective inhibitor of protein SUMOylation, a ubiquitin-like post-translational modification, has been developed, shedding light on the potential for developing new classes of anticancer therapeutics.

Ubiquitin biology: Unraveling the chain

October 18th, 2017 by Grant Miura

Ubiquitin biology: Unraveling the chain

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2508

Hop to It

October 13th, 2017 by Jillian L. Dempsey and Matthew R. Hartings

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DOI: 10.1021/acs.biochem.7b00950

Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner

September 28th, 2017 by Xun Sun, H. Jane Dyson and Peter E. Wright

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DOI: 10.1021/acs.biochem.7b00815

Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH as a Reductant in a Biochemical Context

September 27th, 2017 by Yasunori Okamoto and Thomas R. Ward

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DOI: 10.1021/acs.biochem.7b00809

Cation−π Lights Up “Halo”

September 20th, 2017 by Jianmin Gao

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DOI: 10.1021/acs.biochem.7b00702

Bioorthogonal chemistry: Click on, click off

September 19th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2482

Author: Caitlin Deane

Developmental signaling: Peaking early

September 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2484

Author: Grant Miura

Target class drug discovery

September 19th, 2017 by Kimberly D Barnash

Nature Chemical Biology 13, 1053 (2017). doi:10.1038/nchembio.2473

Authors: Kimberly D Barnash, Lindsey I James & Stephen V Frye

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complimentary approach that has higher quality outcomes in early discovery efforts.

Genome mining: Digging the tunnel for chemical space

September 19th, 2017 by Ha An Nguyen

Nature Chemical Biology 13, 1061 (2017). doi:10.1038/nchembio.2480

Authors: Ha An Nguyen & Christine M Dunham

Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.