Signal Transduction: Notch catches a Jagged edge

May 17th, 2017 by Stephen C Blacklow

Nature Chemical Biology 13, 570 (2017). doi:10.1038/nchembio.2379

Author: Stephen C Blacklow

Notch signaling is an essential cell–cell communication pathway that influences numerous cell fate decisions during development. Structural and biochemical studies of a Notch–Jagged complex dramatically advance current understanding of ligand recognition, and reveal evidence of catch-bond behavior in the complex.

Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

May 17th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 691 (2017). doi:10.1038/nchembio0617-691a

Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
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Optogenetics: Switching with red and blue

May 17th, 2017 by Fuun Kawano

Nature Chemical Biology 13, 573 (2017). doi:10.1038/nchembio.2387

Authors: Fuun Kawano, Fan Shi & Masayuki Yazawa

Multiple optogenetic technologies are required to control biological activity simultaneously with different colors of light. Optimizing a near-infrared-induced heterodimerization system, which can be combined with blue-light-controlled domains, enables precise spatiotemporal control of target molecules in live mammalian cells.

Small-molecule pheromones and hormones controlling nematode development

May 17th, 2017 by Rebecca A Butcher

Nature Chemical Biology 13, 577 (2017). doi:10.1038/nchembio.2356

Author: Rebecca A Butcher

  • Posted in Nat Chem Biol, Publications
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Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain

May 17th, 2017 by Sathish Srinivasan

Nature Chemical Biology 13, 691 (2017). doi:10.1038/nchembio0617-691b

Author: Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellenbogen & Kendall W Nettles

  • Posted in Nat Chem Biol, Publications
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Illuminating developmental biology through photochemistry

May 17th, 2017 by Lukasz Kowalik

Nature Chemical Biology 13, 587 (2017). doi:10.1038/nchembio.2369

Authors: Lukasz Kowalik & James K Chen

Small-molecule phenotypic screening with stem cells

May 17th, 2017 by Andrei Ursu

Nature Chemical Biology 13, 560 (2017). doi:10.1038/nchembio.2383

Authors: Andrei Ursu, Hans R Schöler & Herbert Waldmann

To fully leverage the potential of human-induced pluripotent stem cells (hiPSCs), improved and standardized reprogramming methods and large-scale collections of hiPSC lines are needed, and the stem cell community must embrace chemical biology methodology for target identification and validation.

The perception of strigolactones in vascular plants

May 17th, 2017 by Shelley Lumba

Nature Chemical Biology 13, 599 (2017). doi:10.1038/nchembio.2340

Authors: Shelley Lumba, Duncan Holbrook-Smith & Peter McCourt

Infectious disease: A lethal sugar fix

May 17th, 2017 by Alison Farrell

Nature Chemical Biology 13, 569 (2017). doi:10.1038/nchembio.2400

Author: Alison Farrell

Shaping embryonic development

May 17th, 2017 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 13, 559 (2017). doi:10.1038/nchembio.2403

The growing intersection between chemical tools and principles and developmental biology is providing new insights into the molecular-level details of developmental processes.