5-Formylcytosine to cytosine conversion by C–C bond cleavage <i>in vivo</i>

November 27th, 2017 by Katharina Iwan

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

5-Formylcytosine to cytosine conversion by C–C bond cleavage <i>in vivo</i>, Published online: 27 November 2017; doi:10.1038/nchembio.2531

Direct conversion of 5-fdC into dC by C–C bond breakage is revealed by metabolic tracing studies through incorporation of synthetic stable isotope- and (R)-2′-fluorine-labeled dC and fdC derivatives into the genome of cultured mammalian cells.
  • Posted in Nat Chem Biol, Publications
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Peptide design: Hacking hemagglutinin

November 21st, 2017 by Karin Kuehnel

Peptide design: Hacking hemagglutinin

Peptide design: Hacking hemagglutinin, Published online: 21 November 2017; doi:10.1038/nchembio.2523

Peptide design: Hacking hemagglutinin

Errata: Functional annotation of chemical libraries across diverse biological processes

November 21st, 2017 by Jeff S Piotrowski

Errata: Functional annotation of chemical libraries across diverse biological processes

Errata: Functional annotation of chemical libraries across diverse biological processes, Published online: 21 November 2017; doi:10.1038/nchembio1217-1286a

Errata: Functional annotation of chemical libraries across diverse biological processes
  • Posted in Nat Chem Biol, Publications
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Errata: Functional annotation of chemical libraries across diverse biological processes

November 21st, 2017 by Jeff S Piotrowski

Errata: Functional annotation of chemical libraries across diverse biological processes

Errata: Functional annotation of chemical libraries across diverse biological processes, Published online: 21 November 2017; doi:10.1038/nchembio1217-1286b

Errata: Functional annotation of chemical libraries across diverse biological processes
  • Posted in Nat Chem Biol, Publications
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Genetic code expansion: Synthetases pick up the PACE

November 21st, 2017 by Jeffery M Tharp

Genetic code expansion: Synthetases pick up the PACE

Genetic code expansion: Synthetases pick up the PACE, Published online: 21 November 2017; doi:10.1038/nchembio.2516

Phage-assisted evolution can rapidly improve the efficiency and substrate specificity of orthogonal aminoacyl-tRNA synthetases. Furthermore, the crystal structure of the pyrrolysyl-tRNA synthetase N-terminal domain reveals the basis for these improvements and provides a structural rationale for orthogonality.

Nucleic acids: mRNAs get a TREAT

November 21st, 2017 by Grant Miura

Nucleic acids: mRNAs get a TREAT

Nucleic acids: mRNAs get a TREAT, Published online: 21 November 2017; doi:10.1038/nchembio.2522

Nucleic acids: mRNAs get a TREAT

Cancer systems biology: Harnessing off-target effects

November 21st, 2017 by Gaye Saginc

Cancer systems biology: Harnessing off-target effects

Cancer systems biology: Harnessing off-target effects, Published online: 21 November 2017; doi:10.1038/nchembio.2519

The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.

Host–pathogen interactions: A ubiquitin defense

November 21st, 2017 by Mirella Bucci

Host–pathogen interactions: A ubiquitin defense

Host–pathogen interactions: A ubiquitin defense, Published online: 21 November 2017; doi:10.1038/nchembio.2524

Host–pathogen interactions: A ubiquitin defense

Enzymology: I want my cluster back

November 21st, 2017 by Caitlin Deane

Enzymology: I want my cluster back

Enzymology: I want my cluster back, Published online: 21 November 2017; doi:10.1038/nchembio.2525

Enzymology: I want my cluster back

Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A by CRISPR/dCas9 Combined with Refactoring Self-Protection Genes in Lysobacter enzymogenes OH11

November 20th, 2017 by Lingjun Yu, Wei Su, Paul D. Fey, Fengquan Liu and Liangcheng Du

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00293
  • Posted in ACS Synthetic Biology, Publications
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