The ABCs of PTMs

February 14th, 2018 by Karl W Barber

The ABCs of PTMs

The ABCs of PTMs, Published online: 14 February 2018; doi:10.1038/nchembio.2572

Post-translational modifications (PTMs) are ubiquitous in all forms of life and often modulate critical protein functions. Recent chemical and biological advances have finally enabled scientists to precisely modify proteins at physiologically relevant positions, ushering in a new era of protein studies.

Ubiquitination: Trashing the CIA

February 14th, 2018 by Grant Miura

Ubiquitination: Trashing the CIA

Ubiquitination: Trashing the CIA, Published online: 14 February 2018; doi:10.1038/nchembio.2580

Ubiquitination: Trashing the CIA

Protein evolution: Hacking an enzyme

February 14th, 2018 by Kristoffer E Johansson

Protein evolution: Hacking an enzyme

Protein evolution: Hacking an enzyme, Published online: 14 February 2018; doi:10.1038/nchembio.2574

Early stages of protein evolution are inherently difficult to study. Genetic selection in Escherichia coli has now identified a life-sustaining de novo enzyme arising from a simple scaffold that is completely different from the native enzyme.

Altering form for function

February 14th, 2018 by Nature Chemical Biology - Issue - nature.com science feeds

Altering form for function

Altering form for function, Published online: 14 February 2018; doi:10.1038/nchembio.2582

Elucidating the mechanisms by which biomolecules are chemically modified and how these alterations regulate biological pathways represents a leading frontier in chemical biology.

Viruses: Capsids under pressure

February 14th, 2018 by Mirella Bucci

Viruses: Capsids under pressure

Viruses: Capsids under pressure, Published online: 14 February 2018; doi:10.1038/nchembio.2578

Viruses: Capsids under pressure

How many human proteoforms are there?

February 14th, 2018 by Ruedi Aebersold

How many human proteoforms are there?

How many human proteoforms are there?, Published online: 14 February 2018; doi:10.1038/nchembio.2576

How many human proteoforms are there?

Insights into the biogenesis, function, and regulation of ADP-ribosylation

February 14th, 2018 by Michael S Cohen

Insights into the biogenesis, function, and regulation of ADP-ribosylation

Insights into the biogenesis, function, and regulation of ADP-ribosylation, Published online: 14 February 2018; doi:10.1038/nchembio.2568

Insights into the biogenesis, function, and regulation of ADP-ribosylation
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Understanding the Molecular Mechanisms of the CRISPR Toolbox Using Single Molecule Approaches

February 9th, 2018 by Digvijay Singh and Taekjip Ha

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00905

Development of Activity-Based Chemical Probes for Human Sirtuins

February 8th, 2018 by Elysian Graham, Stacia Rymarchyk, Marci Wood and Yana Cen

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00754

Toward a Microparticle-Based System for Pooled Assays of Small Molecules in Cellular Contexts

February 8th, 2018 by Carrie E. Yozwiak, Tal Hirschhorn and Brent R. Stockwell

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b00043