Fatal chemoattraction

September 17th, 2018 by Mirella Bucci

Fatal chemoattraction

Fatal chemoattraction, Published online: 17 September 2018; doi:10.1038/s41589-018-0140-2

Fatal chemoattraction

Flipping out the peptide

September 17th, 2018 by Stephanie Gras

Flipping out the peptide

Flipping out the peptide, Published online: 17 September 2018; doi:10.1038/s41589-018-0133-1

T cell cross-reactivity enables the immune system to recognize a large array of peptides. A new study shows that T cells can achieve cross-recognition by using the remarkable plasticity of peptides, through flipping the peptide out of the binding cleft.

Diversifying bases

September 17th, 2018 by Yiyun Song

Diversifying bases

Diversifying bases, Published online: 17 September 2018; doi:10.1038/s41589-018-0141-1

Diversifying bases

[ASAP] Kinetic Mechanism of Nicotinamide <italic toggle=”yes”>N</italic>-Methyltransferase

September 9th, 2018 by Heather S. Loring, Paul R. Thompson

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Biochemistry
DOI: 10.1021/acs.biochem.8b00775

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

September 6th, 2018 by Mary E. Matyskiela

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate, Published online: 06 September 2018; doi:10.1038/s41589-018-0129-x

Thalidomide-induced degradation of the transcription factor SALL4 in a cereblon-dependent manner provides an explanation for the teratogenic effects.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis

September 4th, 2018 by Kelsey E. Knewtson, Digamber Rane, Blake R. Peterson

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b00535
  • Posted in ACS Chemical Biology, Publications
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[ASAP] Optimization of Artificial Curcumin Biosynthesis in <italic toggle=”yes”>E. coli</italic> by Randomized 5′-UTR Sequences To Control the Multienzyme Pathway

September 3rd, 2018 by Sun-Young Kang, Kyung Taek Heo, Young-Soo Hong

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00198
  • Posted in ACS Synthetic Biology, Publications
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[ASAP] Tamoxifen- and Mifepristone-Inducible Versions of CRISPR Effectors, Cas9 and Cpf1

September 3rd, 2018 by Alazne Dominguez-Monedero, Jamie A. Davies

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00145

Establishment of the PAR-1 cortical gradient by the aPKC-PRBH circuit

September 3rd, 2018 by Ravikrishna Ramanujam

Establishment of the PAR-1 cortical gradient by the aPKC-PRBH circuit

Establishment of the PAR-1 cortical gradient by the aPKC-PRBH circuit, Published online: 03 September 2018; doi:10.1038/s41589-018-0117-1

The asymmetric cortical gradient of PAR-1 is patterned via an integration of its cortical exclusion and stabilization by a circuit consisting of aPKC and the PRBH protein PAR-2.
  • Posted in Nat Chem Biol, Publications
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Substrate-assisted enzymatic formation of lysinoalanine in duramycin

September 3rd, 2018 by Linna An

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

Substrate-assisted enzymatic formation of lysinoalanine in duramycin, Published online: 03 September 2018; doi:10.1038/s41589-018-0122-4

During the biosynthesis of the lanthipeptide duramycin, DurN catalyzes stereospecific lysinoalanine formation by preorganizing the reactive conformation of the substrate, such that one of the substrate’s own residues serves as the catalytic base.