Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase

June 25th, 2018 by Jiasong Li

Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase

Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase, Published online: 25 June 2018; doi:10.1038/s41589-018-0085-5

Engineered variants of cysteine dioxygenase containing a halogen-substituted tyrosine analog provide insights into the process of Cys–Tyr cross-link formation and indicate that the enzyme can catalyze oxidative cleavage of a carbon–fluorine bond.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase

[ASAP] A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

June 21st, 2018 by Jan-Erik Hoffmann, Dmytro Dziuba, Frank Stein, Carsten Schultz

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00397

[ASAP] So Close, yet Sulfur Away: Opening the Nitrogenase Cofactor Structure Creates a Binding Site

June 20th, 2018 by Kazimer L. Skubi, Patrick L. Holland

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00529

Vitamin B<sub>12</sub> import is all about timing

June 18th, 2018 by Lutz Schmitt

Vitamin B12 import is all about timing

Vitamin B<sub>12</sub> import is all about timing, Published online: 18 June 2018; doi:10.1038/s41589-018-0087-3

Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

Please hold for chaperones

June 18th, 2018 by Caitlin Deane

Please hold for chaperones

Please hold for chaperones, Published online: 18 June 2018; doi:10.1038/s41589-018-0092-6

Please hold for chaperones

Tricks for taking up residence

June 18th, 2018 by Mirella Bucci

Tricks for taking up residence

Tricks for taking up residence, Published online: 18 June 2018; doi:10.1038/s41589-018-0094-4

Tricks for taking up residence

Stabilizing synapsis

June 18th, 2018 by Yiyun Song

Stabilizing synapsis

Stabilizing synapsis, Published online: 18 June 2018; doi:10.1038/s41589-018-0095-3

Stabilizing synapsis

Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD

June 18th, 2018 by Min Yang

Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD

Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD, Published online: 18 June 2018; doi:10.1038/s41589-018-0088-2

A single-molecule approach combined with molecular dynamics simulations to examine the conformational dynamics of the Escherichia coli ABC transporter BtuCD defines a coordinated sequence of events leading to unidirectional transport.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD

Scavenging of superoxide by a membrane-bound superoxide oxidase

June 18th, 2018 by Camilla A. K. Lundgren

Scavenging of superoxide by a membrane-bound superoxide oxidase

Scavenging of superoxide by a membrane-bound superoxide oxidase, Published online: 18 June 2018; doi:10.1038/s41589-018-0072-x

The membrane-bound enzyme CybB can directly oxidize superoxide to molecular oxygen and transfer the sequestered electrons to ubiquinone in vitro, providing a mechanism for superoxide scavenging distinct from that of superoxide dismutase.

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

June 18th, 2018 by Vincent Wiebach

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides, Published online: 18 June 2018; doi:10.1038/s41589-018-0068-6

The antibacterial microvionin contains two new lanthipeptide modifications, a triamino-dicarboxylic acid (avionin) and an N-terminal guanidino fatty acid, that lead to the establishment of the lipolanthine natural product class.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides