[ASAP] Ancient Family of Retinal Proteins Brought to Light “Sight-Unseen”

November 30th, 2018 by Thomas P. Sakmar, Thomas Huber

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Biochemistry
DOI: 10.1021/acs.biochem.8b01188

<i>Escherichia</i> coli “Marionette” strains with 12 highly optimized small-molecule sensors

November 26th, 2018 by Adam J. Meyer

Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors

<i>Escherichia</i> coli “Marionette” strains with 12 highly optimized small-molecule sensors, Published online: 26 November 2018; doi:10.1038/s41589-018-0168-3

A directed evolution approach was applied to optimize a set of 12 small-molecule-responsive biosensors, which led to the engineering of “Marionette” strains of Escherichia coli incorporating these sensors for biotechnological applications.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Discovery and Characterization of a Naturally Occurring, Turn-On Yellow Fluorescent Protein Sensor for Chloride

November 21st, 2018 by Jasmine N. Tutol, Weicheng Peng, Sheel C. Dodani

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Biochemistry
DOI: 10.1021/acs.biochem.8b00928

[ASAP] Understanding and Engineering Distributed Biochemical Pathways in Microbial Communities

November 20th, 2018 by Xinyun Cao, Joshua J. Hamilton, Ophelia S. Venturelli

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Biochemistry
DOI: 10.1021/acs.biochem.8b01006

[ASAP] Hinge–Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity

November 20th, 2018 by Tristan A. Bell, Tania A. Baker, Robert T. Sauer

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Biochemistry
DOI: 10.1021/acs.biochem.8b00907

Polarized displacement by transcription activator-like effectors for regulatory circuits

November 19th, 2018 by Tina Lebar

Polarized displacement by transcription activator-like effectors for regulatory circuits

Polarized displacement by transcription activator-like effectors for regulatory circuits, Published online: 19 November 2018; doi:10.1038/s41589-018-0163-8

The observation that transcription activator-like effectors (TALES) displace TALES bound at adjacent downstream DNA enables engineered regulation of gene expression, displacement of other DNA binding proteins and construction of logic-gated systems.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTa

November 19th, 2018 by Hanqiao Feng, Bing-Rui Zhou, Yawen Bai

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Biochemistry
DOI: 10.1021/acs.biochem.8b01075

Transcriptional recorder

November 14th, 2018 by Yiyun Song

Transcriptional recorder

Transcriptional recorder, Published online: 14 November 2018; doi:10.1038/s41589-018-0174-5

Transcriptional recorder

Expanding the terpenoid kingdom

November 14th, 2018 by Yongjin J. Zhou

Expanding the terpenoid kingdom

Expanding the terpenoid kingdom, Published online: 14 November 2018; doi:10.1038/s41589-018-0167-4

Terpenoids are assembled from five-carbon (C5) units, which limits the available scaffold chemical space for the discovery of bioactive molecules. A combination of enzyme and metabolic engineering now enables biosynthesis of a plethora of non-natural C11 terpenoids.

Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation

November 14th, 2018 by Amanda Poissonnier

Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation

Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation, Published online: 14 November 2018; doi:10.1038/s41589-018-0162-9

The HIV protease inhibitor ritonavir targets the calcium-inducing domain (CID) of CD95 to block interactions with PLCγ1. Peptidomimetics targeting the CD95 CID prevents accumulation of inflammatory Th17 cells observed in systemic lupus erythematosus.
  • Posted in Nat Chem Biol, Publications
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