Target class drug discovery

September 19th, 2017 by Kimberly D Barnash

Nature Chemical Biology 13, 1053 (2017). doi:10.1038/nchembio.2473

Authors: Kimberly D Barnash, Lindsey I James & Stephen V Frye

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complimentary approach that has higher quality outcomes in early discovery efforts.

Genome mining: Digging the tunnel for chemical space

September 19th, 2017 by Ha An Nguyen

Nature Chemical Biology 13, 1061 (2017). doi:10.1038/nchembio.2480

Authors: Ha An Nguyen & Christine M Dunham

Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.

Biosynthesis: SAM cycles up for colibactin

September 19th, 2017 by Steven G Van Lanen

Nature Chemical Biology 13, 1059 (2017). doi:10.1038/nchembio.2479

Author: Steven G Van Lanen

The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

September 19th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137a

Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
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Corrigendum: Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis

September 19th, 2017 by Karine Bastard

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137c

Author: Karine Bastard, Alain Perret, Aline Mariage, Thomas Bessonnet, Agnès Pinet-Turpault, Jean-Louis Petit, Ekaterina Darii, Pascal Bazire, Carine Vergne-Vaxelaire, Clémence Brewee, Adrien Debard, Virginie Pellouin, Marielle Besnard-Gonnet, François Artiguenave, Claudine Médigue, David Vallenet, Antoine Danchin, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat & Véronique de Berardinis

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Detecting Activity at Different Length Scales: From Subdiffraction to Whole-Animal Activity

September 15th, 2017 by Tsz-Leung To and Xiaokun Shu

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Biochemistry
DOI: 10.1021/acs.biochem.7b00788

A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase

September 8th, 2017 by Eric P. Trautman and Jason M. Crawford

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Biochemistry
DOI: 10.1021/acs.biochem.7b00680

Ionic Strength Sensing in Living Cells

September 6th, 2017 by Boqun Liu, Bert Poolman and Arnold J. Boersma

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00348

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8

August 30th, 2017 by Nicholas J. Porter and David W. Christianson

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00330

Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel

August 28th, 2017 by Mikhail Metelev

Nature Chemical Biology 13, 1129 (2017). doi:10.1038/nchembio.2462

Authors: Mikhail Metelev, Ilya A Osterman, Dmitry Ghilarov, Nelli F Khabibullina, Alexander Yakimov, Konstantin Shabalin, Irina Utkina, Dmitry Y Travin, Ekaterina S Komarova, Marina Serebryakova, Tatyana Artamonova, Mikhail Khodorkovskii, Andrey L Konevega, Petr V Sergiev, Konstantin Severinov & Yury S Polikanov

  • Posted in Nat Chem Biol, Publications
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