A CRISPR screen identifies a pathway required for paraquat-induced cell death

October 23rd, 2017 by Colleen R Reczek

A CRISPR screen identifies a pathway required for paraquat-induced cell death

A CRISPR screen identifies a pathway required for paraquat-induced cell death, Published online: 23 October 2017; doi:10.1038/nchembio.2499

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A positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

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Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites

October 18th, 2017 by Jack G. Ganley, Maria Toro-Moreno and Emily R. Derbyshire

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Biochemistry
DOI: 10.1021/acs.biochem.7b00877

Ubiquitin biology: Unraveling the chain

October 18th, 2017 by Grant Miura

Ubiquitin biology: Unraveling the chain

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2508

Bacterial cell wall: Phages breaking free

October 18th, 2017 by Karin Kuehnel

Bacterial cell wall: Phages breaking free

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2506

Biomaterials: Cotton gets superpowers

October 18th, 2017 by Caitlin Deane

Biomaterials: Cotton gets superpowers

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2505

Host-microbe interactions: Aiming at GPCRs

October 18th, 2017 by Mirella Bucci

Host-microbe interactions: Aiming at GPCRs

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2507

Drug discovery: Controlling protein SUMOylation

October 18th, 2017 by John S Schneekloth Jr

Drug discovery: Controlling protein SUMOylation

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2496

A potent and selective inhibitor of protein SUMOylation, a ubiquitin-like post-translational modification, has been developed, shedding light on the potential for developing new classes of anticancer therapeutics.

Hop to It

October 13th, 2017 by Jillian L. Dempsey and Matthew R. Hartings

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Biochemistry
DOI: 10.1021/acs.biochem.7b00950

Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner

September 28th, 2017 by Xun Sun, H. Jane Dyson and Peter E. Wright

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Biochemistry
DOI: 10.1021/acs.biochem.7b00815

Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH as a Reductant in a Biochemical Context

September 27th, 2017 by Yasunori Okamoto and Thomas R. Ward

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Biochemistry
DOI: 10.1021/acs.biochem.7b00809