HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

November 5th, 2018 by Huanbin Wang

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity, Published online: 05 November 2018; doi:10.1038/s41589-018-0161-x

HIP1R directly interacts with PD-L1 and targets PD-L1 for lysosomal degradation. Development of a rationally designed peptide incorporating the PD-L1 binding sequence of HIP1R with a lysosomal targeting sequence promotes PD-L1 degradation.
  • Posted in Nat Chem Biol, Publications
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[ASAP] In Situ Photoregulation of Carbonic Anhydrase Activity Using Azobenzenesulfonamides

October 31st, 2018 by Kanchan Aggarwal, Mandira Banik, Brenda Medellin, Emily L. Que

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Biochemistry
DOI: 10.1021/acs.biochem.8b00947

Small heat shock proteins: Simplicity meets complexity [Cell Biology]

October 31st, 2018 by Martin Haslbeck, Sevil Weinkauf, Johannes Buchner

Small heat shock proteins (sHsps) are a ubiquitous and ancient family of ATP-independent molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso-energetic oligomeric species differing in size. This property arises from a unique mode of assembly involving several parts of the subunits in a flexible manner. Current evidence suggests that smaller oligomers are more active chaperones. Thus, a shift in the equilibrium of the sHsp ensemble allows regulating the chaperone activity. Different mechanisms have been identified that reversibly change the oligomer equilibrium. The promiscuous interaction with non-native proteins generates complexes that can form aggregate-like structures from which native proteins are restored by ATP-dependent chaperones such as Hsp70 family members. In recent years, this basic paradigm has been expanded and new roles, new cofactors as well as variations in structure and regulation of sHsps have emerged.

[ASAP] Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype

October 29th, 2018 by Yue Li, Matthew D. Disney

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b00827
  • Posted in ACS Chemical Biology, Publications
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The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite

October 29th, 2018 by Iria Bernhardsgrütter

The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite

The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite, Published online: 29 October 2018; doi:10.1038/s41589-018-0153-x

Structural and biochemical analysis of propionyl-CoA synthase reveals that it forms a reaction chamber containing three active sites, which sequesters the reactive intermediate acrylyl-CoA during the conversion of 3-hydroxypropionate to propionyl-CoA.
  • Posted in Nat Chem Biol, Publications
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Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking

October 29th, 2018 by Xin Li

Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking

Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking, Published online: 29 October 2018; doi:10.1038/s41589-018-0144-y

An inhibitor of the YEATS domain was developed by targeting a unique π-π-π stacking in the YEATS–Kcr recognition. An ENL YEATS-selective inhibitor, XL-13m, helps probe the YEATS-dependent role of ENL in the leukemogenic transcription program.
  • Posted in Nat Chem Biol, Publications
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Identification of a cellularly active SIRT6 allosteric activator

October 29th, 2018 by Zhimin Huang

Identification of a cellularly active SIRT6 allosteric activator

Identification of a cellularly active SIRT6 allosteric activator, Published online: 29 October 2018; doi:10.1038/s41589-018-0150-0

The use of an allosteric drug-design method resulted in the identification of a first-in-class cellularly active SIRT6 activator that induces cell-cycle arrest in the G0–G1 phase, thus suppressing proliferation in human hepatocellular carcinoma cells.

[ASAP] Retroelement-Based Genome Editing and Evolution

October 25th, 2018 by Anna J. Simon, Barrett R. Morrow, Andrew D. Ellington

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00273

[ASAP] Transcription Driven by Reversible Photocontrol of Hyperstable G-Quadruplexes

October 16th, 2018 by Shinzi Ogasawara

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00216

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

October 16th, 2018 by Martina Wallace

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues, Published online: 16 October 2018; doi:10.1038/s41589-018-0132-2

mmBCFAs are endogenous fatty acids synthesized from BCAAs by brown and white adipose tissue via CrAT and FASN promiscuity. BCAA catabolism and mmBCFA lipogenesis are decreased by obesity-induced adipose hypoxia and influenced by the microbiome.
  • Posted in Nat Chem Biol, Publications
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