Folding against the wind

March 5th, 2018 by Frederick Stull

Folding against the wind

Folding against the wind, Published online: 05 March 2018; doi:10.1038/s41589-018-0016-5

Many thermodynamically unfavorable processes in biology are powered by ATP, the energy currency of the cell. New evidence suggests that chaperone-mediated protein stabilization may need to be added to that list.

Wicket: A Versatile Tool for the Integration and Optimization of Exogenous Pathways in Saccharomyces cerevisiae

February 28th, 2018 by Sha Hou, Qin Qin and Junbiao Dai

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00391
  • Posted in ACS Synthetic Biology, Publications
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Directed Evolution of Membrane Transport Using Synthetic Selections

February 28th, 2018 by Anne P. Bali, Hans J. Genee and Morten O. A. Sommer

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00407

A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

February 26th, 2018 by Kiryl D. Piatkevich

A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Published online: 26 February 2018; doi:10.1038/s41589-018-0004-9

Directed evolution of opsins via robotic high-content screening finds a fluorescent reporter of voltage that is simultaneously optimized for brightness, localization and voltage sensitivity and is applicable in three model systems.
  • Posted in Nat Chem Biol, Publications
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Trp-ing upon new repressors

February 26th, 2018 by Andreas K. Brödel

Trp-ing upon new repressors

Trp-ing upon new repressors, Published online: 26 February 2018; doi:10.1038/s41589-018-0012-9

Bioengineers have used directed evolution to generate a new family of synthetic transcription factors based on the tryptophan repressor. The evolved repressor family enables researchers to build new gene circuits for biomedical applications.

Directed evolution of a synthetic phylogeny of programmable Trp repressors

February 26th, 2018 by Jared W. Ellefson

Directed evolution of a synthetic phylogeny of programmable Trp repressors

Directed evolution of a synthetic phylogeny of programmable Trp repressors, Published online: 26 February 2018; doi:10.1038/s41589-018-0006-7

Directed evolution of Trp repressor (TrpR) variants that are responsive to halogenated tryptophan analogs and recognize new operator sites serve as useful components for constructing complex gene expression networks.
  • Posted in Nat Chem Biol, Publications
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Resistance to nonribosomal peptide antibiotics mediated by <span class=”small-caps”>d</span>-stereospecific peptidases

February 26th, 2018 by Yong-Xin Li

Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Resistance to nonribosomal peptide antibiotics mediated by <span class="small-caps">d</span>-stereospecific peptidases, Published online: 26 February 2018; doi:10.1038/s41589-018-0009-4

Networking-associated genome mining on bacterial genomes followed by chemical and enzymatic analysis identified a mechanism of resistance toward nonribosomal peptide antibiotics based on hydrolytic cleavage by d-stereospecific peptidases.
  • Posted in Nat Chem Biol, Publications
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Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques

February 23rd, 2018 by Sébastien Alphonse, Boris Itin, Reza Khayat and Ranajeet Ghose

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Biochemistry
DOI: 10.1021/acs.biochem.8b00003

Protein Plasticity and Peptide Editing in the MHC I Antigen Processing Pathway

February 22nd, 2018 by Tim Elliott and Andy van Hateren

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Biochemistry
DOI: 10.1021/acs.biochem.7b01307

Orthogonal Information Encoding in Living Cells with High Error-Tolerance, Safety, and Fidelity

February 21st, 2018 by Lifu Song and An-Ping Zeng

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00382