Designing microbial consortia with defined social interactions

June 25th, 2018 by Wentao Kong

Designing microbial consortia with defined social interactions

Designing microbial consortia with defined social interactions, Published online: 25 June 2018; doi:10.1038/s41589-018-0091-7

Synthetic microbial consortia were engineered as experimental models of bacterial interactions within ecosystems, and mathematical models of their behavior were used to design more complex microbial systems with additional interactions.

Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD

June 18th, 2018 by Min Yang

Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD

Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD, Published online: 18 June 2018; doi:10.1038/s41589-018-0088-2

A single-molecule approach combined with molecular dynamics simulations to examine the conformational dynamics of the Escherichia coli ABC transporter BtuCD defines a coordinated sequence of events leading to unidirectional transport.
  • Posted in Nat Chem Biol, Publications
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Scavenging of superoxide by a membrane-bound superoxide oxidase

June 18th, 2018 by Camilla A. K. Lundgren

Scavenging of superoxide by a membrane-bound superoxide oxidase

Scavenging of superoxide by a membrane-bound superoxide oxidase, Published online: 18 June 2018; doi:10.1038/s41589-018-0072-x

The membrane-bound enzyme CybB can directly oxidize superoxide to molecular oxygen and transfer the sequestered electrons to ubiquinone in vitro, providing a mechanism for superoxide scavenging distinct from that of superoxide dismutase.

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

June 18th, 2018 by Vincent Wiebach

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides, Published online: 18 June 2018; doi:10.1038/s41589-018-0068-6

The antibacterial microvionin contains two new lanthipeptide modifications, a triamino-dicarboxylic acid (avionin) and an N-terminal guanidino fatty acid, that lead to the establishment of the lipolanthine natural product class.
  • Posted in Nat Chem Biol, Publications
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The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases

June 18th, 2018 by Suzana Markolovic

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases, Published online: 18 June 2018; doi:10.1038/s41589-018-0071-y

Structural, biochemical and cellular studies reveal JMJD7 to be a Jumonji-C oxygenase that catalyzes (3S)-lysyl hydroxylation of the translation factor family of GTPases, DRG1 and DRG2.
  • Posted in Nat Chem Biol, Publications
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Vitamin B<sub>12</sub> import is all about timing

June 18th, 2018 by Lutz Schmitt

Vitamin B12 import is all about timing

Vitamin B<sub>12</sub> import is all about timing, Published online: 18 June 2018; doi:10.1038/s41589-018-0087-3

Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

Please hold for chaperones

June 18th, 2018 by Caitlin Deane

Please hold for chaperones

Please hold for chaperones, Published online: 18 June 2018; doi:10.1038/s41589-018-0092-6

Please hold for chaperones

Tricks for taking up residence

June 18th, 2018 by Mirella Bucci

Tricks for taking up residence

Tricks for taking up residence, Published online: 18 June 2018; doi:10.1038/s41589-018-0094-4

Tricks for taking up residence

Stabilizing synapsis

June 18th, 2018 by Yiyun Song

Stabilizing synapsis

Stabilizing synapsis, Published online: 18 June 2018; doi:10.1038/s41589-018-0095-3

Stabilizing synapsis

Linkers for protein degradation

June 11th, 2018 by Philip P. Chamberlain

Linkers for protein degradation

Linkers for protein degradation, Published online: 11 June 2018; doi:10.1038/s41589-018-0057-9

The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.