The promise and peril of chemical probes

July 21st, 2015 by Cheryl H Arrowsmith

Nature Chemical Biology 11, 536 (2015). doi:10.1038/nchembio.1867

Authors: Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C O'Hagan, John P Overington, Dafydd R Owen, Saul H Rosenberg, Brian Roth, Ruth Ross, Matthieu Schapira, Stuart L Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A Walters, Timothy M Willson, Paul Workman, Robert N Young & William J Zuercher

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

Protein regulation: Inteins under wraps

July 21st, 2015 by Catherine Goodman

Nature Chemical Biology 11, 548 (2015). doi:10.1038/nchembio.1873

Author: Catherine Goodman

Antibacterials: Clamping down on Mtb

July 21st, 2015 by Mirella Bucci

Nature Chemical Biology 11, 548 (2015). doi:10.1038/nchembio.1875

Author: Mirella Bucci

Protein phosphorylation: KISSing kinases

July 21st, 2015 by Grant Miura

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1877

Author: Grant Miura

Plant development: Fighting for space

July 21st, 2015 by Grant Miura

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1872

Author: Grant Miura

Photopharmacology: Microtubules see the light

July 21st, 2015 by Terry L. Sheppard

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1876

Author: Terry L. Sheppard

Probing questions

July 21st, 2015 by Nature Chemical Biology - Issue - science feeds

Nature Chemical Biology 11, 533 (2015). doi:10.1038/nchembio.1882

Chemical probes are proven tools for biological research and early-stage drug development, but how can chemical biologists make them more useful to the broader scientific community?

Lipid metabolism: Working out SCD’s kinks

July 21st, 2015 by St├ęphane Larochelle

Nature Chemical Biology 11, 548 (2015). doi:10.1038/nchembio.1874

Author: Stéphane Larochelle

Biosynthesis: Leading the way to RiPPs

July 21st, 2015 by A James Link

Nature Chemical Biology 11, 551 (2015). doi:10.1038/nchembio.1862

Author: A James Link

Many peptide-based natural products require a leader peptide to reach their final modified form, but the identification of general rules for leader peptide interactions have been stymied by the diversity of these molecules. Two papers reporting crystallographic and bioinformatic analysis of these systems now reveal a structurally conserved domain that mediates leader peptide binding.

Voices of chemical biology

July 21st, 2015 by Nature Chemical Biology - Issue - science feeds

Nature Chemical Biology 11, 546 (2015). doi:10.1038/nchembio.1880

We asked a collection of chemical biologists: “What is the most significant challenge facing chemical biology as a discipline?”