Proteostasis: Found in translation

May 15th, 2015 by Mirella Bucci

Nature Chemical Biology 11, 380 (2015). doi:10.1038/nchembio.1826

Author: Mirella Bucci

Layers of structure and function in protein aggregation

May 15th, 2015 by Motomasa Tanaka

Nature Chemical Biology 11, 373 (2015). doi:10.1038/nchembio.1818

Authors: Motomasa Tanaka & Yusuke Komi

Protein aggregation is a central hallmark of many neurodegenerative disorders, but the relationship of aggregate structural diversity to the resultant cellular cytotoxicity and phenotypic diversity has remained obscure. Recent advances in understanding the mechanisms of protein aggregation and their physiological consequences have been achieved through chemical biology approaches, such as rationally designed protein modifications and chemical probes, providing crucial mechanistic insights and promise for therapeutic strategies for brain disorders.

Protein structure/folding: Shape your duty

May 15th, 2015 by Angela K. Eggleston

Nature Chemical Biology 11, 380 (2015). doi:10.1038/nchembio.1829

Author: Angela K. Eggleston

Voices of chemical biology

May 15th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 378 (2015). doi:10.1038/nchembio.1820

Agreeing on a precise definition of chemical biology has been a persistent challenge for the field. We asked a diverse group of scientists to “define chemical biology” and present a selection of responses.

Carbohydrates: Inhibitors in an instant

May 15th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 381 (2015). doi:10.1038/nchembio.1825

Author: Catherine Goodman

Cell motility: Bigger and faster

May 15th, 2015 by Mirella Bucci

Nature Chemical Biology 11, 381 (2015). doi:10.1038/nchembio.1828

Author: Mirella Bucci

Archaeochemistry: Raising a glass

May 15th, 2015 by Terry L. Sheppard

Nature Chemical Biology 11, 380 (2015). doi:10.1038/nchembio.1827

Author: Terry L. Sheppard

Membrane fusion: A new role for lipid domains?

May 15th, 2015 by Erwin London

Nature Chemical Biology 11, 383 (2015). doi:10.1038/nchembio.1812

Author: Erwin London

Boundaries between ordered and disordered membrane domains may be the site of HIV fusion protein insertion into its target membrane.

What’s in a name?

May 15th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 363 (2015). doi:10.1038/nchembio.1832

Chemical biology may elude simple definitions, but there remains no question that chemical biologists have crafted a compelling interdisciplinary narrative that advances science and benefits society.

Enzyme pathways: C1 metabolism redesigned

May 15th, 2015 by Yi-Shu Tai

Nature Chemical Biology 11, 384 (2015). doi:10.1038/nchembio.1819

Authors: Yi-Shu Tai & Kechun Zhang

One-carbon metabolic pathways create new opportunities for metabolic engineering, but natural pathways have limitations in catalytic efficiency and interspecies transferability. Now a computationally designed enzyme, formolase, enables the construction of a synthetic metabolic pathway in Escherichia coli for assimilation of formate into a glycolytic intermediate in only five reaction steps.