SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

June 1st, 2015 by James Palacino

Nature Chemical Biology 11, 511 (2015). doi:10.1038/nchembio.1837

Authors: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline Bullock, Michael McLellan, Sven Schuierer, Leo Murphy, Marcel J J Blommers, Cecile Blaustein, Frada Berenshteyn, Arnaud Lacoste, Jason R Thomas, Guglielmo Roma, Gregory A Michaud, Brian S Tseng, Jeffery A Porter, Vic E Myer, John A Tallarico, Lawrence G Hamann, Daniel Curtis, Mark C Fishman, William F Dietrich, Natalie A Dales & Rajeev Sivasankaran

  • Posted in Nat Chem Biol, Publications
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Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride

May 25th, 2015 by Dario A Vitturi

Nature Chemical Biology 11, 504 (2015). doi:10.1038/nchembio.1814

Authors: Dario A Vitturi, Lucia Minarrieta, Sonia R Salvatore, Edward M Postlethwait, Marco Fazzari, Gerardo Ferrer-Sueta, Jack R Lancaster, Bruce A Freeman & Francisco J Schopfer

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Drug-target interactions: Stay tuned

May 25th, 2015 by Robert A Copeland

Nature Chemical Biology 11, 451 (2015). doi:10.1038/nchembio.1831

Author: Robert A Copeland

The ability to vary a drug's residence time on a target is important for drug optimization. A series of reversible covalent inhibitors of select kinases demonstrates the feasibility of tuning residence time from minutes to days through modification of noncovalent features of the molecules.

Prolonged and tunable residence time using reversible covalent kinase inhibitors

May 25th, 2015 by J Michael Bradshaw

Nature Chemical Biology 11, 525 (2015). doi:10.1038/nchembio.1817

Authors: J Michael Bradshaw, Jesse M McFarland, Ville O Paavilainen, Angelina Bisconte, Danny Tam, Vernon T Phan, Sergei Romanov, David Finkle, Jin Shu, Vaishali Patel, Tony Ton, Xiaoyan Li, David G Loughhead, Philip A Nunn, Dane E Karr, Mary E Gerritsen, Jens Oliver Funk, Timothy D Owens, Erik Verner, Ken A Brameld, Ronald J Hill, David M Goldstein & Jack Taunton

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Metabolic engineering: Biosensor keeps DOPA on track

May 18th, 2015 by Pamela Peralta-Yahya

Nature Chemical Biology 11, 450 (2015). doi:10.1038/nchembio.1830

Author: Pamela Peralta-Yahya

Biosensors are emerging as an important tool to evolutionarily engineer metabolic pathway enzymes for the microbial production of chemicals. A colorimetric biosensor used to increase dopamine levels in yeast now enables the production of benzylisoquinoline alkaloids from glucose.

An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

May 18th, 2015 by William C DeLoache

Nature Chemical Biology 11, 465 (2015). doi:10.1038/nchembio.1816

Authors: William C DeLoache, Zachary N Russ, Lauren Narcross, Andrew M Gonzales, Vincent J J Martin & John E Dueber

  • Posted in Nat Chem Biol, Publications
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What’s in a name?

May 15th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 363 (2015). doi:10.1038/nchembio.1832

Chemical biology may elude simple definitions, but there remains no question that chemical biologists have crafted a compelling interdisciplinary narrative that advances science and benefits society.

Enzyme pathways: C1 metabolism redesigned

May 15th, 2015 by Yi-Shu Tai

Nature Chemical Biology 11, 384 (2015). doi:10.1038/nchembio.1819

Authors: Yi-Shu Tai & Kechun Zhang

One-carbon metabolic pathways create new opportunities for metabolic engineering, but natural pathways have limitations in catalytic efficiency and interspecies transferability. Now a computationally designed enzyme, formolase, enables the construction of a synthetic metabolic pathway in Escherichia coli for assimilation of formate into a glycolytic intermediate in only five reaction steps.

Greatest hits

May 15th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 364 (2015). doi:10.1038/nchembio.1815

We present a selection of papers published in Nature Chemical Biology over the past decade that reflect the diversity and excitement of chemical biology research.

Application guide for omics approaches to cell signaling

May 15th, 2015 by Zhong Yao

Nature Chemical Biology 11, 387 (2015). doi:10.1038/nchembio.1809

Authors: Zhong Yao, Julia Petschnigg, Robin Ketteler & Igor Stagljar