Membrane curvature bends the laws of physics and chemistry

October 20th, 2015 by Lars Iversen

Nature Chemical Biology 11, 822 (2015). doi:10.1038/nchembio.1941

Authors: Lars Iversen, Signe Mathiasen, Jannik Bruun Larsen & Dimitrios Stamou

A 'chemical biology of cellular membranes' must capture the way that mesoscale perturbations tune the biochemical properties of constituent lipid and protein molecules and vice versa. Whereas the classical paradigm focuses on chemical composition, dynamic modulation of the physical shape or curvature of a membrane is emerging as a complementary and synergistic modus operandi for regulating cellular membrane biology.

Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology

October 20th, 2015 by Eunji Kim

Nature Chemical Biology 11, 887 (2015). doi:10.1038/nchembio1115-887a

Author: Eunji Kim, Bradley S Moore & Yeo Joon Yoon

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Plant toxicology: Defusing the explosive

October 20th, 2015 by Grant Miura

Nature Chemical Biology 11, 829 (2015). doi:10.1038/nchembio.1947

Author: Grant Miura

Voices of chemical biology

October 20th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 826 (2015). doi:10.1038/nchembio.1951

We asked a collection of chemical biologists: “What advice would you give to a junior scientist interested in pursuing a career in chemical biology?”

Metabolomics: Budgeting on a diet

October 20th, 2015 by Grant Miura

Nature Chemical Biology 11, 828 (2015). doi:10.1038/nchembio.1944

Author: Grant Miura

RNA profiling: A better miR trap

October 20th, 2015 by Terry L Sheppard

Nature Chemical Biology 11, 828 (2015). doi:10.1038/nchembio.1942

Author: Terry L Sheppard

Microbiology: Membranes get the gold

October 20th, 2015 by Mirella Bucci

Nature Chemical Biology 11, 829 (2015). doi:10.1038/nchembio.1946

Author: Mirella Bucci

Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching

October 19th, 2015 by Srividhya Sundaram

Nature Chemical Biology 11, 949 (2015). doi:10.1038/nchembio.1932

Authors: Srividhya Sundaram, Daniel Heine & Christian Hertweck

Biosynthesis of rhizoxin in Burkholderia rhizoxinica affords an unusual polyketide synthase module with ketosynthase and branching domains that install the δ-lactone, conferring antimitotic activity. To investigate their functions in chain branching, we designed chimeric modules with structurally similar domains from a glutarimide-forming module and a dehydratase. Biochemical, kinetic and mutational analyses reveal a structural role of the accessory domains and multifarious catalytic actions of the ketosynthase.

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Chemical libraries: How dark is HTS dark matter?

October 19th, 2015 by Ricardo Macarron

Nature Chemical Biology 11, 904 (2015). doi:10.1038/nchembio.1937

Author: Ricardo Macarron

Selecting compounds for the chemical library is the foundation of high-throughput screening (HTS). After some years and multiple HTS campaigns, many molecules in the Novartis and NIH Molecular Libraries Program screening collections have never been found to be active. An in-depth exploration of the bioactivity of this 'dark matter' does in fact reveal some compounds of interest.

Dark chemical matter as a promising starting point for drug lead discovery

October 19th, 2015 by Anne Mai Wassermann

Nature Chemical Biology 11, 958 (2015). doi:10.1038/nchembio.1936

Authors: Anne Mai Wassermann, Eugen Lounkine, Dominic Hoepfner, Gaelle Le Goff, Frederick J King, Christian Studer, John M Peltier, Melissa L Grippo, Vivian Prindle, Jianshi Tao, Ansgar Schuffenhauer, Iain M Wallace, Shanni Chen, Philipp Krastel, Amanda Cobos-Correa, Christian N Parker, John W Davies & Meir Glick

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