Protein degradation: Prime time for PROTACs

August 18th, 2015 by Raymond J Deshaies

Nature Chemical Biology 11, 634 (2015). doi:10.1038/nchembio.1887

Author: Raymond J Deshaies

PROTACs are heterobifunctional small molecules that simultaneously bind a target protein and a ubiquitin ligase, enabling ubiquitination and degradation of the target. Major progress in developing potent and specific PROTACs has recently been reported, invigorating prospects for novel PROTAC-based therapies.

The structural biology of biosynthetic megaenzymes

August 18th, 2015 by Kira J Weissman

Nature Chemical Biology 11, 660 (2015). doi:10.1038/nchembio.1883

Author: Kira J Weissman

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways

August 17th, 2015 by Tomas Blom

Nature Chemical Biology 11, 799 (2015). doi:10.1038/nchembio.1889

Authors: Tomas Blom, Shiqian Li, Andrea Dichlberger, Nils Bäck, Young Ah Kim, Ursula Loizides-Mangold, Howard Riezman, Robert Bittman & Elina Ikonen

  • Posted in Nat Chem Biol, Publications
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A fungal monooxygenase-derived jasmonate attenuates host innate immunity

August 10th, 2015 by Rajesh N Patkar

Nature Chemical Biology 11, 733 (2015). doi:10.1038/nchembio.1885

Authors: Rajesh N Patkar, Peter I Benke, Ziwei Qu, Yuan Yi Constance Chen, Fan Yang, Sanjay Swarup & Naweed I Naqvi

  • Posted in Nat Chem Biol, Publications
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An excess of catalytically required motions inhibits the scavenger decapping enzyme

August 10th, 2015 by Ancilla Neu

Nature Chemical Biology 11, 697 (2015). doi:10.1038/nchembio.1866

Authors: Ancilla Neu, Ursula Neu, Anna-Lisa Fuchs, Benjamin Schlager & Remco Sprangers

  • Posted in Nat Chem Biol, Publications
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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

August 3rd, 2015 by Reiko Ueoka

Nature Chemical Biology 11, 705 (2015). doi:10.1038/nchembio.1870

Authors: Reiko Ueoka, Agustinus R Uria, Silke Reiter, Tetsushi Mori, Petra Karbaum, Eike E Peters, Eric J N Helfrich, Brandon I Morinaka, Muriel Gugger, Haruko Takeyama, Shigeki Matsunaga & Jörn Piel

  • Posted in Nat Chem Biol, Publications
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Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity

August 3rd, 2015 by Isabelle B Jacques

Nature Chemical Biology 11, 721 (2015). doi:10.1038/nchembio.1868

Authors: Isabelle B Jacques, Mireille Moutiez, Jerzy Witwinowski, Emmanuelle Darbon, Cécile Martel, Jérôme Seguin, Emmanuel Favry, Robert Thai, Alain Lecoq, Steven Dubois, Jean-Luc Pernodet, Muriel Gondry & Pascal Belin

  • Posted in Nat Chem Biol, Publications
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The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif

July 27th, 2015 by Leslie K Williams

Nature Chemical Biology 11, 691 (2015). doi:10.1038/nchembio.1865

Authors: Leslie K Williams, Xiaohua Zhang, Sami Caner, Christina Tysoe, Nham T Nguyen, Jacqueline Wicki, David E Williams, John Coleman, John H McNeill, Violet Yuen, Raymond J Andersen, Stephen G Withers & Gary D Brayer

  • Posted in Nat Chem Biol, Publications
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Tunable and reversible drug control of protein production via a self-excising degron

July 27th, 2015 by Hokyung K Chung

Nature Chemical Biology 11, 713 (2015). doi:10.1038/nchembio.1869

Authors: Hokyung K Chung, Conor L Jacobs, Yunwen Huo, Jin Yang, Stefanie A Krumm, Richard K Plemper, Roger Y Tsien & Michael Z Lin

  • Posted in Nat Chem Biol, Publications
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Plant development: Fighting for space

July 21st, 2015 by Grant Miura

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1872

Author: Grant Miura