Control of carotenoid biosynthesis through a heme-based cis-trans isomerase

June 15th, 2015 by Jesús Beltrán

Nature Chemical Biology 11, 598 (2015). doi:10.1038/nchembio.1840

Authors: Jesús Beltrán, Brian Kloss, Jonathan P Hosler, Jiafeng Geng, Aimin Liu, Anuja Modi, John H Dawson, Masanori Sono, Maria Shumskaya, Charles Ampomah-Dwamena, James D Love & Eleanore T Wurtzel

  • Posted in Nat Chem Biol, Publications
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Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome

June 15th, 2015 by Xiaoyu Li

Nature Chemical Biology 11, 592 (2015). doi:10.1038/nchembio.1836

Authors: Xiaoyu Li, Ping Zhu, Shiqing Ma, Jinghui Song, Jinyi Bai, Fangfang Sun & Chengqi Yi

  • Posted in Nat Chem Biol, Publications
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Catalytic in vivo protein knockdown by small-molecule PROTACs

June 10th, 2015 by Daniel P Bondeson

Nature Chemical Biology 11, 611 (2015). doi:10.1038/nchembio.1858

Authors: Daniel P Bondeson, Alina Mares, Ian E D Smith, Eunhwa Ko, Sebastien Campos, Afjal H Miah, Katie E Mulholland, Natasha Routly, Dennis L Buckley, Jeffrey L Gustafson, Nico Zinn, Paola Grandi, Satoko Shimamura, Giovanna Bergamini, Maria Faelth-Savitski, Marcus Bantscheff, Carly Cox, Deborah A Gordon, Ryan R Willard, John J Flanagan, Linda N Casillas, Bartholomew J Votta, Willem den Besten, Kristoffer Famm, Laurens Kruidenier, Paul S Carter, John D Harling, Ian Churcher & Craig M Crews

Infiltration of chitin by protein coacervates defines the squid beak mechanical gradient

June 8th, 2015 by YerPeng Tan

Nature Chemical Biology 11, 488 (2015). doi:10.1038/nchembio.1833

Authors: YerPeng Tan, Shawn Hoon, Paul A Guerette, Wei Wei, Ali Ghadban, Cai Hao, Ali Miserez & J Herbert Waite

  • Posted in Nat Chem Biol, Publications
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Biomaterials: Recipe for squid beak

June 8th, 2015 by Markus B Linder

Nature Chemical Biology 11, 455 (2015). doi:10.1038/nchembio.1842

Author: Markus B Linder

The molecular basis of biomaterial assembly and function can provide inspiration for new materials science designs. New research explains the squid beak's transition from soft to hard through the identification of two new families of proteins with unusual physical properties.

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

June 8th, 2015 by Fan Yang

Nature Chemical Biology 11, 518 (2015). doi:10.1038/nchembio.1835

Authors: Fan Yang, Xian Xiao, Wei Cheng, Wei Yang, Peilin Yu, Zhenzhen Song, Vladimir Yarov-Yarovoy & Jie Zheng

  • Posted in Nat Chem Biol, Publications
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Nontoxic antimicrobials that evade drug resistance

June 1st, 2015 by Stephen A Davis

Nature Chemical Biology 11, 481 (2015). doi:10.1038/nchembio.1821

Authors: Stephen A Davis, Benjamin M Vincent, Matthew M Endo, Luke Whitesell, Karen Marchillo, David R Andes, Susan Lindquist & Martin D Burke

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

June 1st, 2015 by Daniel T Rogerson

Nature Chemical Biology 11, 496 (2015). doi:10.1038/nchembio.1823

Authors: Daniel T Rogerson, Amit Sachdeva, Kaihang Wang, Tamanna Haq, Agne Kazlauskaite, Susan M Hancock, Nicolas Huguenin-Dezot, Miratul M K Muqit, Andrew M Fry, Richard Bayliss & Jason W Chin

  • Posted in Nat Chem Biol, Publications
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SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

June 1st, 2015 by James Palacino

Nature Chemical Biology 11, 511 (2015). doi:10.1038/nchembio.1837

Authors: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline Bullock, Michael McLellan, Sven Schuierer, Leo Murphy, Marcel J J Blommers, Cecile Blaustein, Frada Berenshteyn, Arnaud Lacoste, Jason R Thomas, Guglielmo Roma, Gregory A Michaud, Brian S Tseng, Jeffery A Porter, Vic E Myer, John A Tallarico, Lawrence G Hamann, Daniel Curtis, Mark C Fishman, William F Dietrich, Natalie A Dales & Rajeev Sivasankaran

  • Posted in Nat Chem Biol, Publications
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Antifungal design: The toxicity-resistance yin-yang

June 1st, 2015 by David M Geiser

Nature Chemical Biology 11, 453 (2015). doi:10.1038/nchembio.1838

Author: David M Geiser

A modified amphotericin antifungal that is less toxic to human cells, owing to its increased preference for its fungal ergosterol target versus human cholesterol, can still evade the evolution of resistance.