Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

July 30th, 2018 by William H. Zhang

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS, Published online: 30 July 2018; doi:10.1038/s41589-018-0108-2

A genetically encoded FRET-based optical sensor generated from a computational design approach can monitor hippocampal glycine levels in brain tissue to determine differences between spines and shafts and changes induced by high- and low-frequency stimulation.
  • Posted in Nat Chem Biol, Publications
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A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells

July 30th, 2018 by Esther Braselmann

A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells

A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells, Published online: 30 July 2018; doi:10.1038/s41589-018-0103-7

A new riboswitch-based RNA sensor called Riboglow binds to quenched fluorescent probes to induce fluorescence turn-on. Riboglow enables tagging and tracking of mRNA and short noncoding RNAs with different colored fluorophores in live mammalian cells.
  • Posted in Nat Chem Biol, Publications
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Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

July 30th, 2018 by Ron Hermenau

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system, Published online: 30 July 2018; doi:10.1038/s41589-018-0101-9

Plant-associated rhizosphere bacteria produce gramibactin, a cyclic lipodepsipeptide siderophore that tightly binds iron via an unexpected functional group, the N-nitrosohydroxylamine (diazeniumdiolate) moieties of the amino acid graminine.
  • Posted in Nat Chem Biol, Publications
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Crowd control

July 17th, 2018 by Grant Miura

Crowd control

Crowd control, Published online: 17 July 2018; doi:10.1038/s41589-018-0109-1

Crowd control

3D interaction hubs

July 17th, 2018 by Yiyun Song

3D interaction hubs

3D interaction hubs, Published online: 17 July 2018; doi:10.1038/s41589-018-0112-6

3D interaction hubs

Antigen processing movers and shakers

July 17th, 2018 by Tim Elliott

Antigen processing movers and shakers

Antigen processing movers and shakers, Published online: 17 July 2018; doi:10.1038/s41589-018-0106-4

Monitoring MHC-I dynamics upon binding to its chaperone TAPBPR helps us understand how optimal peptide sequences are selected for presentation and coordinated with release of the chaperone from the ternary peptide–MHC-I–TAPBPR complex.

Caught in the act

July 17th, 2018 by Karin Kuehnel

Caught in the act

Caught in the act, Published online: 17 July 2018; doi:10.1038/s41589-018-0110-8

Caught in the act

Dopamine gets lit

July 17th, 2018 by Mirella Bucci

Dopamine gets lit

Dopamine gets lit, Published online: 17 July 2018; doi:10.1038/s41589-018-0111-7

Dopamine gets lit

A remote control for switching

July 17th, 2018 by Marc Vendrell

A remote control for switching

A remote control for switching, Published online: 17 July 2018; doi:10.1038/s41589-018-0107-3

Calcium channels are crucial regulators of a broad range of biological processes. A photoswitchable chemical probe allows the opening and closing of these channels with unprecedented temporal resolution, providing new opportunities to study calcium-dependent signaling pathways in real time.

Facile target validation in an animal model with intracellularly expressed monobodies

July 16th, 2018 by Ankit Gupta

Facile target validation in an animal model with intracellularly expressed monobodies

Facile target validation in an animal model with intracellularly expressed monobodies, Published online: 16 July 2018; doi:10.1038/s41589-018-0099-z

The development of a selective and potent monobody to WDR5, a component of the mixed linear leukemia methyltransferase complex, as genetically encoded inhibitor enables suppression of leukemogenesis and confers survival in a mouse leukemia model.
  • Posted in Nat Chem Biol, Publications
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