Antibiotics: Synergistic MRSA combinations

October 20th, 2015 by Karen Bush

Nature Chemical Biology 11, 832 (2015). doi:10.1038/nchembio.1935

Author: Karen Bush

Meropenem/piperacillin/tazobactam is a triple β-lactam combination that kills MRSA in vitro and in a mouse model through a novel synergistic mechanism of action. Similar activity for other carbapenem/β-lactam combinations suggests that MRSA infections might be treatable with combinations of established β-lactams currently classified as ineffective against MRSA.

Corrigendum: The promise and peril of chemical probes

October 20th, 2015 by Cheryl H Arrowsmith

Nature Chemical Biology 11, 887 (2015). doi:10.1038/nchembio1115-887c

Author: Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Mathias Frederiksen, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C O'Hagan, John P Overington, Dafydd R Owen, Saul H Rosenberg, Ruth Ross, Bryan Roth, Matthieu Schapira, Stuart L Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A Walters, Timothy M Willson, Paul Workman, Robert N Young & William J Zuercher

Metabolism: Plugging the leak

October 20th, 2015 by Bryan C Dickinson

Nature Chemical Biology 11, 831 (2015). doi:10.1038/nchembio.1934

Author: Bryan C Dickinson

Multiple mitochondrial components generate reactive oxygen species (ROS), but separating the consequences of each ROS-generating source from overall mitochondrial health is challenging. A new class of small-molecule inhibitors that selectively block ROS generation from one of the most active sources may provide a new approach toward achieving that goal.

Glycobiology: Interior decorating

October 20th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 829 (2015). doi:10.1038/nchembio.1945

Author: Catherine Goodman

The ins and outs of selective kinase inhibitor development

October 20th, 2015 by Susanne Müller

Nature Chemical Biology 11, 818 (2015). doi:10.1038/nchembio.1938

Authors: Susanne Müller, Apirat Chaikuad, Nathanael S Gray & Stefan Knapp

Protein kinases have emerged as one of the most successful families of drug targets. To date, most selective kinase inhibitors have been discovered serendipitously either through broad selectivity screening or through the discovery of unique binding modes. Here we discuss design strategies that could lead to a broader coverage of the kinome with selective inhibitors and to a more rational approach for developing them.

Metalloenzymes: A tungsten triple play

October 20th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 828 (2015). doi:10.1038/nchembio.1943

Author: Catherine Goodman

Corrigendum: Protein degradation: Prime time for PROTACs

October 20th, 2015 by Raymond J Deshaies

Nature Chemical Biology 11, 887 (2015). doi:10.1038/nchembio1115-887b

Author: Raymond J Deshaies

Membrane curvature bends the laws of physics and chemistry

October 20th, 2015 by Lars Iversen

Nature Chemical Biology 11, 822 (2015). doi:10.1038/nchembio.1941

Authors: Lars Iversen, Signe Mathiasen, Jannik Bruun Larsen & Dimitrios Stamou

A 'chemical biology of cellular membranes' must capture the way that mesoscale perturbations tune the biochemical properties of constituent lipid and protein molecules and vice versa. Whereas the classical paradigm focuses on chemical composition, dynamic modulation of the physical shape or curvature of a membrane is emerging as a complementary and synergistic modus operandi for regulating cellular membrane biology.

Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology

October 20th, 2015 by Eunji Kim

Nature Chemical Biology 11, 887 (2015). doi:10.1038/nchembio1115-887a

Author: Eunji Kim, Bradley S Moore & Yeo Joon Yoon

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology

Plant toxicology: Defusing the explosive

October 20th, 2015 by Grant Miura

Nature Chemical Biology 11, 829 (2015). doi:10.1038/nchembio.1947

Author: Grant Miura