Metalloenzymes: Getting the gold

January 19th, 2016 by Catherine Goodman

Nature Chemical Biology 12, 53 (2016). doi:10.1038/nchembio.2014

Author: Catherine Goodman

Antivirals: Alphaviruses feel the STING

January 19th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 53 (2016). doi:10.1038/nchembio.2012

Author: Mirella Bucci

Oxidative damage: A pathway to stress

January 19th, 2016 by St├ęphane Larochelle

Nature Chemical Biology 12, 53 (2016). doi:10.1038/nchembio.2013

Author: Stéphane Larochelle

Fatty acylation of Wnt proteins

January 19th, 2016 by Aaron H Nile

Nature Chemical Biology 12, 60 (2016). doi:10.1038/nchembio.2005

Authors: Aaron H Nile & Rami N Hannoush

Synthetic biology: Building genetic containment

January 19th, 2016 by Karmella A Haynes

Nature Chemical Biology 12, 55 (2016). doi:10.1038/nchembio.2004

Author: Karmella A Haynes

Since the 1980s, scientists have worked on designing genetic codes to reinforce containment and control of genetically engineered microbes. New mechanistic studies of “deadman” and “passcode” gene circuits provide a flexible platform to build new safety switches.

Chemical probes: The many genes of drug mechanism

January 19th, 2016 by Adam C Palmer

Nature Chemical Biology 12, 57 (2016). doi:10.1038/nchembio.2010

Author: Adam C Palmer

A small molecule's biological activity in a cell depends on the actions of many gene products. Correlations between basal gene expression and compound sensitivity across hundreds of human cell lines reveal a broad view of cellular mechanisms of action.

Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence

January 18th, 2016 by Feifei Chen

Nature Chemical Biology 12, 174 (2016). doi:10.1038/nchembio.2003

Authors: Feifei Chen, Hongxia Di, Youxin Wang, Qiao Cao, Bin Xu, Xue Zhang, Nana Yang, Guijie Liu, Cai-Guang Yang, Yong Xu, Hualiang Jiang, Fulin Lian, Naixia Zhang, Jian Li & Lefu Lan

  • Posted in Nat Chem Biol, Publications
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Addicting diverse bacteria to a noncanonical amino acid

January 18th, 2016 by Drew S Tack

Nature Chemical Biology 12, 138 (2016). doi:10.1038/nchembio.2002

Authors: Drew S Tack, Jared W Ellefson, Ross Thyer, Bo Wang, Jimmy Gollihar, Matthew T Forster & Andrew D Ellington

Engineered orthogonal translation systems have greatly enabled the expansion of the genetic code using noncanonical amino acids (NCAAs). However, the impact of NCAAs on organismal evolution remains unclear, in part because it is difficult to force the adoption of new genetic codes in organisms. By reengineering TEM-1 β-lactamase to be dependent on a NCAA, we maintained bacterial NCAA dependence for hundreds of generations without escape.

A topological and conformational stability alphabet for multipass membrane proteins

January 18th, 2016 by Xiang Feng

Nature Chemical Biology 12, 167 (2016). doi:10.1038/nchembio.2001

Authors: Xiang Feng & Patrick Barth

  • Posted in Nat Chem Biol, Publications
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Frequency and amplitude control of cortical oscillations by phosphoinositide waves

January 11th, 2016 by Ding Xiong

Nature Chemical Biology 12, 159 (2016). doi:10.1038/nchembio.2000

Authors: Ding Xiong, Shengping Xiao, Su Guo, Qingsong Lin, Fubito Nakatsu & Min Wu

  • Posted in Nat Chem Biol, Publications
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