Plant development: Fighting for space

July 21st, 2015 by Grant Miura

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1872

Author: Grant Miura

Photopharmacology: Microtubules see the light

July 21st, 2015 by Terry L. Sheppard

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1876

Author: Terry L. Sheppard

Probing questions

July 21st, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 533 (2015). doi:10.1038/nchembio.1882

Chemical probes are proven tools for biological research and early-stage drug development, but how can chemical biologists make them more useful to the broader scientific community?

Lipid metabolism: Working out SCD’s kinks

July 21st, 2015 by St├ęphane Larochelle

Nature Chemical Biology 11, 548 (2015). doi:10.1038/nchembio.1874

Author: Stéphane Larochelle

Biosynthesis: Leading the way to RiPPs

July 21st, 2015 by A James Link

Nature Chemical Biology 11, 551 (2015). doi:10.1038/nchembio.1862

Author: A James Link

Many peptide-based natural products require a leader peptide to reach their final modified form, but the identification of general rules for leader peptide interactions have been stymied by the diversity of these molecules. Two papers reporting crystallographic and bioinformatic analysis of these systems now reveal a structurally conserved domain that mediates leader peptide binding.

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

July 20th, 2015 by A Sloan Devlin

Nature Chemical Biology 11, 685 (2015). doi:10.1038/nchembio.1864

Authors: A Sloan Devlin & Michael A Fischbach

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A biosynthetic pathway for a prominent class of microbiota-derived bile acids

A new metal binding domain involved in cadmium, cobalt and zinc transport

July 20th, 2015 by Aaron T Smith

Nature Chemical Biology 11, 678 (2015). doi:10.1038/nchembio.1863

Authors: Aaron T Smith, Dulmini Barupala, Timothy L Stemmler & Amy C Rosenzweig

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A new metal binding domain involved in cadmium, cobalt and zinc transport

New classes of self-cleaving ribozymes revealed by comparative genomics analysis

July 13th, 2015 by Zasha Weinberg

Nature Chemical Biology 11, 606 (2015). doi:10.1038/nchembio.1846

Authors: Zasha Weinberg, Peter B Kim, Tony H Chen, Sanshu Li, Kimberly A Harris, Christina E Lünse & Ronald R Breaker

  • Posted in Nat Chem Biol, Publications
  • Comments Off on New classes of self-cleaving ribozymes revealed by comparative genomics analysis

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

July 13th, 2015 by Brandon J Burkhart

Nature Chemical Biology 11, 564 (2015). doi:10.1038/nchembio.1856

Authors: Brandon J Burkhart, Graham A Hudson, Kyle L Dunbar & Douglas A Mitchell

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

Epigenetics: Disrupting histone lysine methylation

July 13th, 2015 by Patrick Trojer

Nature Chemical Biology 11, 552 (2015). doi:10.1038/nchembio.1861

Author: Patrick Trojer

A small molecule targeting the protein-protein interaction between a chromatin binding protein and an oncogenic transcription factor shows therapeutic potential in a subtype of acute myeloid leukemia.