Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity

August 3rd, 2015 by Isabelle B Jacques

Nature Chemical Biology 11, 721 (2015). doi:10.1038/nchembio.1868

Authors: Isabelle B Jacques, Mireille Moutiez, Jerzy Witwinowski, Emmanuelle Darbon, Cécile Martel, Jérôme Seguin, Emmanuel Favry, Robert Thai, Alain Lecoq, Steven Dubois, Jean-Luc Pernodet, Muriel Gondry & Pascal Belin

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The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif

July 27th, 2015 by Leslie K Williams

Nature Chemical Biology 11, 691 (2015). doi:10.1038/nchembio.1865

Authors: Leslie K Williams, Xiaohua Zhang, Sami Caner, Christina Tysoe, Nham T Nguyen, Jacqueline Wicki, David E Williams, John Coleman, John H McNeill, Violet Yuen, Raymond J Andersen, Stephen G Withers & Gary D Brayer

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Tunable and reversible drug control of protein production via a self-excising degron

July 27th, 2015 by Hokyung K Chung

Nature Chemical Biology 11, 713 (2015). doi:10.1038/nchembio.1869

Authors: Hokyung K Chung, Conor L Jacobs, Yunwen Huo, Jin Yang, Stefanie A Krumm, Richard K Plemper, Roger Y Tsien & Michael Z Lin

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Plant development: Fighting for space

July 21st, 2015 by Grant Miura

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1872

Author: Grant Miura

Photopharmacology: Microtubules see the light

July 21st, 2015 by Terry L. Sheppard

Nature Chemical Biology 11, 549 (2015). doi:10.1038/nchembio.1876

Author: Terry L. Sheppard

Probing questions

July 21st, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 533 (2015). doi:10.1038/nchembio.1882

Chemical probes are proven tools for biological research and early-stage drug development, but how can chemical biologists make them more useful to the broader scientific community?

Lipid metabolism: Working out SCD’s kinks

July 21st, 2015 by St├ęphane Larochelle

Nature Chemical Biology 11, 548 (2015). doi:10.1038/nchembio.1874

Author: Stéphane Larochelle

Biosynthesis: Leading the way to RiPPs

July 21st, 2015 by A James Link

Nature Chemical Biology 11, 551 (2015). doi:10.1038/nchembio.1862

Author: A James Link

Many peptide-based natural products require a leader peptide to reach their final modified form, but the identification of general rules for leader peptide interactions have been stymied by the diversity of these molecules. Two papers reporting crystallographic and bioinformatic analysis of these systems now reveal a structurally conserved domain that mediates leader peptide binding.

Voices of chemical biology

July 21st, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 546 (2015). doi:10.1038/nchembio.1880

We asked a collection of chemical biologists: “What is the most significant challenge facing chemical biology as a discipline?”

Curation of chemogenomics data

July 21st, 2015 by Denis Fourches

Nature Chemical Biology 11, 535 (2015). doi:10.1038/nchembio.1881

Authors: Denis Fourches, Eugene Muratov & Alexander Tropsha