Mechanism of hydrogen activation by [NiFe] hydrogenases

November 30th, 2015 by Rhiannon M Evans

Nature Chemical Biology 12, 46 (2016). doi:10.1038/nchembio.1976

Authors: Rhiannon M Evans, Emily J Brooke, Sara A M Wehlin, Elena Nomerotskaia, Frank Sargent, Stephen B Carr, Simon E V Phillips & Fraser A Armstrong

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

November 23rd, 2015 by Po-Ssu Huang

Nature Chemical Biology 12, 29 (2016). doi:10.1038/nchembio.1966

Authors: Po-Ssu Huang, Kaspar Feldmeier, Fabio Parmeggiani, D Alejandro Fernandez Velasco, Birte Höcker & David Baker

  • Posted in Nat Chem Biol, Publications
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CRISPR-Cas9–based target validation for p53-reactivating model compounds

November 23rd, 2015 by Michael Wanzel

Nature Chemical Biology 12, 22 (2016). doi:10.1038/nchembio.1965

Authors: Michael Wanzel, Jonas B Vischedyk, Miriam P Gittler, Niklas Gremke, Julia R Seiz, Mirjam Hefter, Magdalena Noack, Rajkumar Savai, Marco Mernberger, Joël P Charles, Jean Schneikert, Anne Catherine Bretz, Andrea Nist & Thorsten Stiewe

  • Posted in Nat Chem Biol, Publications
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Tumor immunology: Assembling the T cell

November 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1969

Author: Grant Miura

Metals: A hydride out of hiding

November 17th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1971

Author: Catherine Goodman

RNA folding: A clear path to RNA catalysis

November 17th, 2015 by Amanda Solem

Nature Chemical Biology 11, 906 (2015). doi:10.1038/nchembio.1954

Authors: Amanda Solem & Alain Laederach

A new high-resolution crystal structure of the subdomain from a catalytically active group II intron reveals important conformational rearrangements necessary to achieve the fully formed catalyst. This structure provides the first atomic-resolution structure of an RNA folding intermediate.

Progress and challenges for chemical probing of RNA structure inside living cells

November 17th, 2015 by Miles Kubota

Nature Chemical Biology 11, 933 (2015). doi:10.1038/nchembio.1958

Authors: Miles Kubota, Catherine Tran & Robert C Spitale

  • Posted in Nat Chem Biol, Publications
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RNA modification: Stressing the message

November 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1970

Author: Grant Miura

Imaging and manipulating proteins in live cells through covalent labeling

November 17th, 2015 by Lin Xue

Nature Chemical Biology 11, 917 (2015). doi:10.1038/nchembio.1959

Authors: Lin Xue, Iuliia A Karpenko, Julien Hiblot & Kai Johnsson

  • Posted in Nat Chem Biol, Publications
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Targeting transcription is no longer a quixotic quest

November 17th, 2015 by Anna K Mapp

Nature Chemical Biology 11, 891 (2015). doi:10.1038/nchembio.1962

Authors: Anna K Mapp, Rachel Pricer & Steven Sturlis

Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.