RNA modification: Translating for growth

February 16th, 2016 by Grant Miura

Nature Chemical Biology 12, 125 (2016). doi:10.1038/nchembio.2034

Author: Grant Miura

Target identification: Getting cholesterol out

February 16th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 125 (2016). doi:10.1038/nchembio.2032

Author: Mirella Bucci

Allosteric substrate switching in a voltage-sensing lipid phosphatase

February 15th, 2016 by Sasha S Grimm

Nature Chemical Biology 12, 261 (2016). doi:10.1038/nchembio.2022

Authors: Sasha S Grimm & Ehud Y Isacoff

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Allosteric substrate switching in a voltage-sensing lipid phosphatase

Allostery: A lipid two-step

February 15th, 2016 by Liang Hong

Nature Chemical Biology 12, 202 (2016). doi:10.1038/nchembio.2037

Authors: Liang Hong & Francesco Tombola

A sensor of membrane depolarization controls the activity of a bound enzyme through a novel mechanism involving two sequential voltage-dependent transitions allosterically coupled to changes in the substrate specificity of the catalytic domain.

YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids

February 15th, 2016 by Gaetano Speciale

Nature Chemical Biology 12, 215 (2016). doi:10.1038/nchembio.2023

Authors: Gaetano Speciale, Yi Jin, Gideon J Davies, Spencer J Williams & Ethan D Goddard-Borger

Sulfoquinovose is produced by photosynthetic organisms at a rate of 1010 tons per annum and is degraded by bacteria as a source of carbon and sulfur. We have identified Escherichia coli YihQ as the first dedicated sulfoquinovosidase and the gateway enzyme to sulfoglycolytic pathways. Structural and mutagenesis studies unveiled the sequence signatures for binding the distinguishing sulfonate residue and revealed that sulfoquinovoside degradation is widespread across the tree of life.

  • Posted in Nat Chem Biol, Publications
  • Comments Off on YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids

Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome

February 10th, 2016 by Xiaoyu Li

Nature Chemical Biology 12, 311 (2016). doi:10.1038/nchembio.2040

Authors: Xiaoyu Li, Xushen Xiong, Kun Wang, Lixia Wang, Xiaoting Shu, Shiqing Ma & Chengqi Yi

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome

A transcription activator–like effector (TALE) induction system mediated by proteolysis

February 8th, 2016 by Matthew F Copeland

Nature Chemical Biology 12, 254 (2016). doi:10.1038/nchembio.2021

Authors: Matthew F Copeland, Mark C Politz, Charles B Johnson, Andrew L Markley & Brian F Pfleger

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A transcription activator–like effector (TALE) induction system mediated by proteolysis

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

February 8th, 2016 by Jessika Valero-González

Nature Chemical Biology 12, 240 (2016). doi:10.1038/nchembio.2019

Authors: Jessika Valero-González, Christina Leonhard-Melief, Erandi Lira-Navarrete, Gonzalo Jiménez-Osés, Cristina Hernández-Ruiz, María Carmen Pallarés, Inmaculada Yruela, Deepika Vasudevan, Anabel Lostao, Francisco Corzana, Hideyuki Takeuchi, Robert S Haltiwanger & Ramon Hurtado-Guerrero

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

Engineering nonphosphorylative metabolism to generate lignocellulose-derived products

February 8th, 2016 by Yi-Shu Tai

Nature Chemical Biology 12, 247 (2016). doi:10.1038/nchembio.2020

Authors: Yi-Shu Tai, Mingyong Xiong, Pooja Jambunathan, Jingyu Wang, Jilong Wang, Cole Stapleton & Kechun Zhang

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Engineering nonphosphorylative metabolism to generate lignocellulose-derived products

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

February 1st, 2016 by Fei Mo

Nature Chemical Biology 12, 226 (2016). doi:10.1038/nchembio.2017

Authors: Fei Mo, Xiaoxuan Zhuang, Xing Liu, Phil Y Yao, Bo Qin, Zeqi Su, Jianye Zang, Zhiyong Wang, Jiancun Zhang, Zhen Dou, Changlin Tian, Maikun Teng, Liwen Niu, Donald L Hill, Guowei Fang, Xia Ding, Chuanhai Fu & Xuebiao Yao

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation