Raft-based interactions of gangliosides with a GPI-anchored receptor
April 4th, 2016 by Naoko Komura
Nature Chemical Biology 12, 402 (2016). doi:10.1038/nchembio.2059
Authors: Naoko Komura, Kenichi G N Suzuki, Hiromune Ando, Miku Konishi, Machi Koikeda, Akihiro Imamura, Rahul Chadda, Takahiro K Fujiwara, Hisae Tsuboi, Ren Sheng, Wonhwa Cho, Koichi Furukawa, Keiko Furukawa, Yoshio Yamauchi, Hideharu Ishida, Akihiro Kusumi & Makoto Kiso
AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs
March 28th, 2016 by William H Parsons
Nature Chemical Biology 12, 367 (2016). doi:10.1038/nchembio.2051
Authors: William H Parsons, Matthew J Kolar, Siddhesh S Kamat, Armand B Cognetta III, Jonathan J Hulce, Enrique Saez, Barbara B Kahn, Alan Saghatelian & Benjamin F Cravatt
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
March 28th, 2016 by Richard M Deans
Nature Chemical Biology 12, 361 (2016). doi:10.1038/nchembio.2050
Authors: Richard M Deans, David W Morgens, Ayşe Ökesli, Sirika Pillay, Max A Horlbeck, Martin Kampmann, Luke A Gilbert, Amy Li, Roberto Mateo, Mark Smith, Jeffrey S Glenn, Jan E Carette, Chaitan Khosla & Michael C Bassik
Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling
March 28th, 2016 by Geoffrey A Smith
Nature Chemical Biology 12, 373 (2016). doi:10.1038/nchembio.2056
Authors: Geoffrey A Smith, Kenji Uchida, Arthur Weiss & Jack Taunton
Steric trapping reveals a cooperativity network in the intramembrane protease GlpG
March 21st, 2016 by Ruiqiong Guo
Nature Chemical Biology 12, 353 (2016). doi:10.1038/nchembio.2048
Authors: Ruiqiong Guo, Kristen Gaffney, Zhongyu Yang, Miyeon Kim, Suttipun Sungsuwan, Xuefei Huang, Wayne L Hubbell & Heedeok Hong
Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis
March 21st, 2016 by Yi Xiao
Nature Chemical Biology 12, 339 (2016). doi:10.1038/nchembio.2046
Authors: Yi Xiao, Christopher H Bowen, Di Liu & Fuzhong Zhang
Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage
March 21st, 2016 by Ling Liu
Nature Chemical Biology 12, 345 (2016). doi:10.1038/nchembio.2047
Authors: Ling Liu, Supriya Shah, Jing Fan, Junyoung O Park, Kathryn E Wellen & Joshua D Rabinowitz
Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
March 18th, 2016 by James Palacino
Nature Chemical Biology 12, 304 (2016). doi:10.1038/nchembio0416-304c
Author: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline Bullock, Michael McLellan, Sven Schuierer, Leo Murphy, Marcel J J Blommers, Cecile Blaustein, Frada Berenshteyn, Arnaud Lacoste, Jason R Thomas, Guglielmo Roma, Gregory A Michaud, Brian S Tseng, Jeffery A Porter, Vic E Myer, John A Tallarico, Lawrence G Hamann,, Daniel Curtis, Mark C Fishman, William F Dietrich, Natalie A Dales & Rajeev Sivasankaran
Drug discovery: One without the other
March 18th, 2016 by Mirella Bucci
Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2055
Author: Mirella Bucci
Transcription: 7SK’s enhanced roles
March 18th, 2016 by Terry L. Sheppard
Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2053
Author: Terry L. Sheppard