Imaging and manipulating proteins in live cells through covalent labeling
November 17th, 2015 by Lin Xue
Nature Chemical Biology 11, 917 (2015). doi:10.1038/nchembio.1959
Authors: Lin Xue, Iuliia A Karpenko, Julien Hiblot & Kai Johnsson
Targeting transcription is no longer a quixotic quest
November 17th, 2015 by Anna K Mapp
Nature Chemical Biology 11, 891 (2015). doi:10.1038/nchembio.1962
Authors: Anna K Mapp, Rachel Pricer & Steven Sturlis
Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.
Virology: MicroRNA-lipid one-upmanship
November 17th, 2015 by Patricia A Thibault
Nature Chemical Biology 11, 905 (2015). doi:10.1038/nchembio.1953
Authors: Patricia A Thibault & Joyce A Wilson
25-Hydroxycholesterol induces miR-185 to suppress lipid and cholesterol synthesis pathways and inhibit viruses such as hepatitis C virus (HCV), that use host membranes to propagate. HCV counteracts this by suppressing miR-185 expression to drive increased cellular lipid content.
Intrinsically disordered proteins: I like to move it, move it
November 17th, 2015 by Joshua M. Finkelstein
Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1972
Author: Joshua M. Finkelstein
Discovery and characterization of smORF-encoded bioactive polypeptides
November 17th, 2015 by Alan Saghatelian
Nature Chemical Biology 11, 909 (2015). doi:10.1038/nchembio.1964
Authors: Alan Saghatelian & Juan Pablo Couso
XFELs open a new era in structural chemical biology
November 17th, 2015 by Petra Fromme
Nature Chemical Biology 11, 895 (2015). doi:10.1038/nchembio.1968
Author: Petra Fromme
X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method's great potential to make new structural discoveries, such as the ability to generate molecular movies of biomolecules at work.
Future perfect
November 17th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds
Nature Chemical Biology 11, 889 (2015). doi:10.1038/nchembio.1977
Abundant frontiers at the interface of chemistry and biology promise another decade of technological innovation and scientific discovery by chemical biologists.
Riboswitches: A bacterial antivitamin
November 17th, 2015 by Terry L. Sheppard
Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1973
Author: Terry L. Sheppard
Chemical modulators of ribosome biogenesis as biological probes
November 17th, 2015 by Jonathan M Stokes
Nature Chemical Biology 11, 924 (2015). doi:10.1038/nchembio.1957
Authors: Jonathan M Stokes & Eric D Brown
Voices of chemical biology
November 17th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds
Nature Chemical Biology 11, 900 (2015). doi:10.1038/nchembio.1975
We asked a collection of chemical biologists: “What is the most exciting frontier area in chemical biology, and what key technology is needed to advance knowledge and applications at this frontier?”