Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

September 17th, 2015 by Florian Grebien

Nature Chemical Biology 11, 815 (2015). doi:10.1038/nchembio1015-815b

Author: Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil, Dalia Barsyte-Lovejoy, Fengling Li, Gennadiy Poda, Matthieu Schapira, Hong Wu, Aiping Dong, Guillermo Senisterra, Alexey Stukalov, Kilian V M Huber, Andreas Schönegger, Richard Marcellus, Martin Bilban, Christoph Bock, Peter J Brown, Johannes Zuber, Keiryn L Bennett, Rima Al-awar, Ruud Delwel, Claus Nerlov, Cheryl H Arrowsmith & Giulio Superti-Furga

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Metalloproteins: Simple structure, complex function

September 17th, 2015 by Angela Lombardi

Nature Chemical Biology 11, 760 (2015). doi:10.1038/nchembio.1918

Author: Angela Lombardi

The four-helix bundle is a simple structural motif, widespread in nature, that is involved in numerous and fundamental processes. This portfolio is now expanded by the report of a four-helix bundle protein able to store copper for particulate methane monooxygenase, an enzyme that catalyzes methane oxidation.

Plant development: Wave-up call

September 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 754 (2015). doi:10.1038/nchembio.1920

Author: Grant Miura

Riboswitches: Sound the alarm

September 17th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 755 (2015). doi:10.1038/nchembio.1924

Author: Catherine Goodman

Nucleotide metabolism: Salvaging chemotherapy

September 17th, 2015 by Terry L. Sheppard

Nature Chemical Biology 11, 754 (2015). doi:10.1038/nchembio.1921

Author: Terry L. Sheppard

Metals: Calprotectin and iron match up

September 17th, 2015 by Guenter Weiss

Nature Chemical Biology 11, 756 (2015). doi:10.1038/nchembio.1915

Author: Guenter Weiss

Iron availability plays a decisive role in host-pathogen interaction, and limitation of iron availability to microbes has been characterized as an effective host defense strategy. The identification of the iron-scavenging property of the neutrophil protein calprotectin adds an important new piece to this concept of nutritional immunity.

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

September 14th, 2015 by Patrick R Gonzales

Nature Chemical Biology 11, 855 (2015). doi:10.1038/nchembio.1911

Authors: Patrick R Gonzales, Mitchell W Pesesky, Renee Bouley, Anna Ballard, Brent A Biddy, Mark A Suckow, William R Wolter, Valerie A Schroeder, Carey-Ann D Burnham, Shahriar Mobashery, Mayland Chang & Gautam Dantas

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Suppressors of superoxide production from mitochondrial complex III

September 14th, 2015 by Adam L Orr

Nature Chemical Biology 11, 834 (2015). doi:10.1038/nchembio.1910

Authors: Adam L Orr, Leonardo Vargas, Carolina N Turk, Janine E Baaten, Jason T Matzen, Victoria J Dardov, Stephen J Attle, Jing Li, Douglas C Quackenbush, Renata L S Goncalves, Irina V Perevoshchikova, H Michael Petrassi, Shelly L Meeusen, Edward K Ainscow & Martin D Brand

Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.

A biomimetic approach for enhancing the in vivo half-life of peptides

September 7th, 2015 by Sravan C Penchala

Nature Chemical Biology 11, 793 (2015). doi:10.1038/nchembio.1907

Authors: Sravan C Penchala, Mark R Miller, Arindom Pal, Jin Dong, Nikhil R Madadi, Jinghang Xie, Hyun Joo, Jerry Tsai, Patrick Batoon, Vyacheslav Samoshin, Andreas Franz, Trever Cox, Jesse Miles, William K Chan, Miki S Park & Mamoun M Alhamadsheh

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Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

September 7th, 2015 by Ralph E Kleiner

Nature Chemical Biology 11, 807 (2015). doi:10.1038/nchembio.1908

Authors: Ralph E Kleiner, Priyanka Verma, Kelly R Molloy, Brian T Chait & Tarun M Kapoor

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