Imaging and manipulating proteins in live cells through covalent labeling

November 17th, 2015 by Lin Xue

Nature Chemical Biology 11, 917 (2015). doi:10.1038/nchembio.1959

Authors: Lin Xue, Iuliia A Karpenko, Julien Hiblot & Kai Johnsson

  • Posted in Nat Chem Biol, Publications
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Targeting transcription is no longer a quixotic quest

November 17th, 2015 by Anna K Mapp

Nature Chemical Biology 11, 891 (2015). doi:10.1038/nchembio.1962

Authors: Anna K Mapp, Rachel Pricer & Steven Sturlis

Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.

Virology: MicroRNA-lipid one-upmanship

November 17th, 2015 by Patricia A Thibault

Nature Chemical Biology 11, 905 (2015). doi:10.1038/nchembio.1953

Authors: Patricia A Thibault & Joyce A Wilson

25-Hydroxycholesterol induces miR-185 to suppress lipid and cholesterol synthesis pathways and inhibit viruses such as hepatitis C virus (HCV), that use host membranes to propagate. HCV counteracts this by suppressing miR-185 expression to drive increased cellular lipid content.

Intrinsically disordered proteins: I like to move it, move it

November 17th, 2015 by Joshua M. Finkelstein

Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1972

Author: Joshua M. Finkelstein

Discovery and characterization of smORF-encoded bioactive polypeptides

November 17th, 2015 by Alan Saghatelian

Nature Chemical Biology 11, 909 (2015). doi:10.1038/nchembio.1964

Authors: Alan Saghatelian & Juan Pablo Couso

  • Posted in Nat Chem Biol, Publications
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XFELs open a new era in structural chemical biology

November 17th, 2015 by Petra Fromme

Nature Chemical Biology 11, 895 (2015). doi:10.1038/nchembio.1968

Author: Petra Fromme

X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method's great potential to make new structural discoveries, such as the ability to generate molecular movies of biomolecules at work.

Future perfect

November 17th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 889 (2015). doi:10.1038/nchembio.1977

Abundant frontiers at the interface of chemistry and biology promise another decade of technological innovation and scientific discovery by chemical biologists.

Riboswitches: A bacterial antivitamin

November 17th, 2015 by Terry L. Sheppard

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1973

Author: Terry L. Sheppard

Chemical modulators of ribosome biogenesis as biological probes

November 17th, 2015 by Jonathan M Stokes

Nature Chemical Biology 11, 924 (2015). doi:10.1038/nchembio.1957

Authors: Jonathan M Stokes & Eric D Brown

Voices of chemical biology

November 17th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 900 (2015). doi:10.1038/nchembio.1975

We asked a collection of chemical biologists: “What is the most exciting frontier area in chemical biology, and what key technology is needed to advance knowledge and applications at this frontier?”