Molecular mechanism of respiratory syncytial virus fusion inhibitors

December 7th, 2015 by Michael B Battles

Nature Chemical Biology 12, 87 (2016). doi:10.1038/nchembio.1982

Authors: Michael B Battles, Johannes P Langedijk, Polina Furmanova-Hollenstein, Supranee Chaiwatpongsakorn, Heather M Costello, Leen Kwanten, Luc Vranckx, Paul Vink, Steffen Jaensch, Tim H M Jonckers, Anil Koul, Eric Arnoult, Mark E Peeples, Dirk Roymans & Jason S McLellan

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

November 30th, 2015 by Lincoln Pasquina

Nature Chemical Biology 12, 40 (2016). doi:10.1038/nchembio.1967

Authors: Lincoln Pasquina, John P Santa Maria, B McKay Wood, Samir H Moussa, Leigh M Matano, Marina Santiago, Sara E S Martin, Wonsik Lee, Timothy C Meredith & Suzanne Walker

  • Posted in Nat Chem Biol, Publications
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Mechanism of hydrogen activation by [NiFe] hydrogenases

November 30th, 2015 by Rhiannon M Evans

Nature Chemical Biology 12, 46 (2016). doi:10.1038/nchembio.1976

Authors: Rhiannon M Evans, Emily J Brooke, Sara A M Wehlin, Elena Nomerotskaia, Frank Sargent, Stephen B Carr, Simon E V Phillips & Fraser A Armstrong

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

November 23rd, 2015 by Po-Ssu Huang

Nature Chemical Biology 12, 29 (2016). doi:10.1038/nchembio.1966

Authors: Po-Ssu Huang, Kaspar Feldmeier, Fabio Parmeggiani, D Alejandro Fernandez Velasco, Birte Höcker & David Baker

  • Posted in Nat Chem Biol, Publications
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CRISPR-Cas9–based target validation for p53-reactivating model compounds

November 23rd, 2015 by Michael Wanzel

Nature Chemical Biology 12, 22 (2016). doi:10.1038/nchembio.1965

Authors: Michael Wanzel, Jonas B Vischedyk, Miriam P Gittler, Niklas Gremke, Julia R Seiz, Mirjam Hefter, Magdalena Noack, Rajkumar Savai, Marco Mernberger, Joël P Charles, Jean Schneikert, Anne Catherine Bretz, Andrea Nist & Thorsten Stiewe

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Tumor immunology: Assembling the T cell

November 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1969

Author: Grant Miura

Metals: A hydride out of hiding

November 17th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1971

Author: Catherine Goodman

RNA folding: A clear path to RNA catalysis

November 17th, 2015 by Amanda Solem

Nature Chemical Biology 11, 906 (2015). doi:10.1038/nchembio.1954

Authors: Amanda Solem & Alain Laederach

A new high-resolution crystal structure of the subdomain from a catalytically active group II intron reveals important conformational rearrangements necessary to achieve the fully formed catalyst. This structure provides the first atomic-resolution structure of an RNA folding intermediate.

Progress and challenges for chemical probing of RNA structure inside living cells

November 17th, 2015 by Miles Kubota

Nature Chemical Biology 11, 933 (2015). doi:10.1038/nchembio.1958

Authors: Miles Kubota, Catherine Tran & Robert C Spitale

  • Posted in Nat Chem Biol, Publications
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RNA modification: Stressing the message

November 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1970

Author: Grant Miura