Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

March 28th, 2016 by Richard M Deans

Nature Chemical Biology 12, 361 (2016). doi:10.1038/nchembio.2050

Authors: Richard M Deans, David W Morgens, Ayşe Ökesli, Sirika Pillay, Max A Horlbeck, Martin Kampmann, Luke A Gilbert, Amy Li, Roberto Mateo, Mark Smith, Jeffrey S Glenn, Jan E Carette, Chaitan Khosla & Michael C Bassik

  • Posted in Nat Chem Biol, Publications
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Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling

March 28th, 2016 by Geoffrey A Smith

Nature Chemical Biology 12, 373 (2016). doi:10.1038/nchembio.2056

Authors: Geoffrey A Smith, Kenji Uchida, Arthur Weiss & Jack Taunton

  • Posted in Nat Chem Biol, Publications
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AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

March 28th, 2016 by William H Parsons

Nature Chemical Biology 12, 367 (2016). doi:10.1038/nchembio.2051

Authors: William H Parsons, Matthew J Kolar, Siddhesh S Kamat, Armand B Cognetta III, Jonathan J Hulce, Enrique Saez, Barbara B Kahn, Alan Saghatelian & Benjamin F Cravatt

  • Posted in Nat Chem Biol, Publications
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Steric trapping reveals a cooperativity network in the intramembrane protease GlpG

March 21st, 2016 by Ruiqiong Guo

Nature Chemical Biology 12, 353 (2016). doi:10.1038/nchembio.2048

Authors: Ruiqiong Guo, Kristen Gaffney, Zhongyu Yang, Miyeon Kim, Suttipun Sungsuwan, Xuefei Huang, Wayne L Hubbell & Heedeok Hong

  • Posted in Nat Chem Biol, Publications
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Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

March 21st, 2016 by Yi Xiao

Nature Chemical Biology 12, 339 (2016). doi:10.1038/nchembio.2046

Authors: Yi Xiao, Christopher H Bowen, Di Liu & Fuzhong Zhang

  • Posted in Nat Chem Biol, Publications
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Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage

March 21st, 2016 by Ling Liu

Nature Chemical Biology 12, 345 (2016). doi:10.1038/nchembio.2047

Authors: Ling Liu, Supriya Shah, Jing Fan, Junyoung O Park, Kathryn E Wellen & Joshua D Rabinowitz

  • Posted in Nat Chem Biol, Publications
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Drug discovery: One without the other

March 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2055

Author: Mirella Bucci

Transcription: 7SK’s enhanced roles

March 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2053

Author: Terry L. Sheppard

Signal transduction: Lowered exchange rates

March 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2054

Author: Grant Miura

Host-microbe interactions: Intake control

March 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2052

Author: Mirella Bucci