Pharmacological chaperones: A new lens on cataract

December 17th, 2015 by Mirella Bucci

Nature Chemical Biology 12, 1 (2016). doi:10.1038/nchembio.1993

Author: Mirella Bucci

Probe discovery: Disentangling gene networks

December 17th, 2015 by Finbarr Hayes

Nature Chemical Biology 12, 3 (2016). doi:10.1038/nchembio.1983

Author: Finbarr Hayes

Cell-wall biogenesis in bacteria involves multiple intersecting gene networks. A powerful approach that allies synthetic lethality with small-molecule discovery has now been used to probe these networks and has revealed that the pathway for D-alanylation of teichoic acids in Staphylococcus aureus is a viable target for new antibacterials.

Microscopy techniques: A localization module

December 17th, 2015 by Mirella Bucci

Nature Chemical Biology 12, 1 (2016). doi:10.1038/nchembio.1994

Author: Mirella Bucci

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

December 14th, 2015 by Matthew G Rees

Nature Chemical Biology 12, 109 (2016). doi:10.1038/nchembio.1986

Authors: Matthew G Rees, Brinton Seashore-Ludlow, Jaime H Cheah, Drew J Adams, Edmund V Price, Shubhroz Gill, Sarah Javaid, Matthew E Coletti, Victor L Jones, Nicole E Bodycombe, Christian K Soule, Benjamin Alexander, Ava Li, Philip Montgomery, Joanne D Kotz, C Suk-Yee Hon, Benito Munoz, Ted Liefeld, Vlado Dančík, Daniel A Haber, Clary B Clish, Joshua A Bittker, Michelle Palmer, Bridget K Wagner, Paul A Clemons, Alykhan F Shamji & Stuart L Schreiber

  • Posted in Nat Chem Biol, Publications
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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

December 14th, 2015 by Luc de Waal

Nature Chemical Biology 12, 102 (2016). doi:10.1038/nchembio.1984

Authors: Luc de Waal, Timothy A Lewis, Matthew G Rees, Aviad Tsherniak, Xiaoyun Wu, Peter S Choi, Lara Gechijian, Christina Hartigan, Patrick W Faloon, Mark J Hickey, Nicola Tolliday, Steven A Carr, Paul A Clemons, Benito Munoz, Bridget K Wagner, Alykhan F Shamji, Angela N Koehler, Monica Schenone, Alex B Burgin, Stuart L Schreiber, Heidi Greulich & Matthew Meyerson

  • Posted in Nat Chem Biol, Publications
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Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

December 14th, 2015 by Tamjeed Saleh

Nature Chemical Biology 12, 117 (2016). doi:10.1038/nchembio.1981

Authors: Tamjeed Saleh, Wojciech Jankowski, Ganapathy Sriram, Paolo Rossi, Shreyas Shah, Ki-Bum Lee, Lissette Alicia Cruz, Alexis J Rodriguez, Raymond B Birge & Charalampos G Kalodimos

  • Posted in Nat Chem Biol, Publications
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An in vivo platform for identifying inhibitors of protein aggregation

December 14th, 2015 by Janet C Saunders

Nature Chemical Biology 12, 94 (2016). doi:10.1038/nchembio.1988

Authors: Janet C Saunders, Lydia M Young, Rachel A Mahood, Matthew P Jackson, Charlotte H Revill, Richard J Foster, D Alastair Smith, Alison E Ashcroft, David J Brockwell & Sheena E Radford

  • Posted in Nat Chem Biol, Publications
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High-throughput analysis and protein engineering using microcapillary arrays

December 7th, 2015 by Bob Chen

Nature Chemical Biology 12, 76 (2016). doi:10.1038/nchembio.1978

Authors: Bob Chen, Sungwon Lim, Arvind Kannan, Spencer C Alford, Fanny Sunden, Daniel Herschlag, Ivan K Dimov, Thomas M Baer & Jennifer R Cochran

  • Posted in Nat Chem Biol, Publications
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‘Deadman’ and ‘Passcode’ microbial kill switches for bacterial containment

December 7th, 2015 by Clement T Y Chan

Nature Chemical Biology 12, 82 (2016). doi:10.1038/nchembio.1979

Authors: Clement T Y Chan, Jeong Wook Lee, D Ewen Cameron, Caleb J Bashor & James J Collins

  • Posted in Nat Chem Biol, Publications
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Protein engineering: Beating the odds

December 7th, 2015 by Uwe T Bornscheuer

Nature Chemical Biology 12, 54 (2016). doi:10.1038/nchembio.1989

Author: Uwe T Bornscheuer

Recently developed advanced microfluidics-based systems have outperformed known screening tools with respect to throughput, flexibility, sensitivity and tricks for hit recovery. This has enabled the discovery of novel and improved proteins from random mutagenesis libraries or metagenome-based sources.