Optimized second-generation CRY2–CIB dimerizers and photoactivatable Cre recombinase

April 11th, 2016 by Amir Taslimi

Nature Chemical Biology 12, 425 (2016). doi:10.1038/nchembio.2063

Authors: Amir Taslimi, Brian Zoltowski, Jose G Miranda, Gopal P Pathak, Robert M Hughes & Chandra L Tucker

  • Posted in Nat Chem Biol, Publications
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Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking

April 11th, 2016 by Mai Khanh Nguyen

Nature Chemical Biology 12, 431 (2016). doi:10.1038/nchembio.2064

Authors: Mai Khanh Nguyen, Cha Yeon Kim, Jin Man Kim, Byung Ouk Park, Sangkyu Lee, Hyerim Park & Won Do Heo

  • Posted in Nat Chem Biol, Publications
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Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus

April 11th, 2016 by Joshua A Baccile

Nature Chemical Biology 12, 419 (2016). doi:10.1038/nchembio.2061

Authors: Joshua A Baccile, Joseph E Spraker, Henry H Le, Eileen Brandenburger, Christian Gomez, Jin Woo Bok, Juliane Macheleidt, Axel A Brakhage, Dirk Hoffmeister, Nancy P Keller & Frank C Schroeder

  • Posted in Nat Chem Biol, Publications
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A synthetic biochemistry module for production of bio-based chemicals from glucose

April 11th, 2016 by Paul H Opgenorth

Nature Chemical Biology 12, 393 (2016). doi:10.1038/nchembio.2062

Authors: Paul H Opgenorth, Tyler P Korman & James U Bowie

Synthetic biochemistry, the cell-free production of biologically based chemicals, is a potentially high-yield, flexible alternative to in vivo metabolic engineering. To limit costs, cell-free systems must be designed to operate continuously with minimal addition of feedstock chemicals. We describe a robust, efficient synthetic glucose breakdown pathway and implement it for the production of bioplastic. The system's performance suggests that synthetic biochemistry has the potential to become a viable industrial alternative.

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Raft-based interactions of gangliosides with a GPI-anchored receptor

April 4th, 2016 by Naoko Komura

Nature Chemical Biology 12, 402 (2016). doi:10.1038/nchembio.2059

Authors: Naoko Komura, Kenichi G N Suzuki, Hiromune Ando, Miku Konishi, Machi Koikeda, Akihiro Imamura, Rahul Chadda, Takahiro K Fujiwara, Hisae Tsuboi, Ren Sheng, Wonhwa Cho, Koichi Furukawa, Keiko Furukawa, Yoshio Yamauchi, Hideharu Ishida, Akihiro Kusumi & Makoto Kiso

Decoding Polo-like kinase 1 signaling along the kinetochore–centromere axis

April 4th, 2016 by Robert F Lera

Nature Chemical Biology 12, 411 (2016). doi:10.1038/nchembio.2060

Authors: Robert F Lera, Gregory K Potts, Aussie Suzuki, James M Johnson, Edward D Salmon, Joshua J Coon & Mark E Burkard

  • Posted in Nat Chem Biol, Publications
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Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

March 28th, 2016 by Richard M Deans

Nature Chemical Biology 12, 361 (2016). doi:10.1038/nchembio.2050

Authors: Richard M Deans, David W Morgens, Ayşe Ökesli, Sirika Pillay, Max A Horlbeck, Martin Kampmann, Luke A Gilbert, Amy Li, Roberto Mateo, Mark Smith, Jeffrey S Glenn, Jan E Carette, Chaitan Khosla & Michael C Bassik

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Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling

March 28th, 2016 by Geoffrey A Smith

Nature Chemical Biology 12, 373 (2016). doi:10.1038/nchembio.2056

Authors: Geoffrey A Smith, Kenji Uchida, Arthur Weiss & Jack Taunton

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AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

March 28th, 2016 by William H Parsons

Nature Chemical Biology 12, 367 (2016). doi:10.1038/nchembio.2051

Authors: William H Parsons, Matthew J Kolar, Siddhesh S Kamat, Armand B Cognetta III, Jonathan J Hulce, Enrique Saez, Barbara B Kahn, Alan Saghatelian & Benjamin F Cravatt

  • Posted in Nat Chem Biol, Publications
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Steric trapping reveals a cooperativity network in the intramembrane protease GlpG

March 21st, 2016 by Ruiqiong Guo

Nature Chemical Biology 12, 353 (2016). doi:10.1038/nchembio.2048

Authors: Ruiqiong Guo, Kristen Gaffney, Zhongyu Yang, Miyeon Kim, Suttipun Sungsuwan, Xuefei Huang, Wayne L Hubbell & Heedeok Hong

  • Posted in Nat Chem Biol, Publications
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