Plant toxicology: Defusing the explosive

October 20th, 2015 by Grant Miura

Nature Chemical Biology 11, 829 (2015). doi:10.1038/nchembio.1947

Author: Grant Miura

Voices of chemical biology

October 20th, 2015 by Nature Chemical Biology - Issue - science feeds

Nature Chemical Biology 11, 826 (2015). doi:10.1038/nchembio.1951

We asked a collection of chemical biologists: “What advice would you give to a junior scientist interested in pursuing a career in chemical biology?”

Metabolomics: Budgeting on a diet

October 20th, 2015 by Grant Miura

Nature Chemical Biology 11, 828 (2015). doi:10.1038/nchembio.1944

Author: Grant Miura

RNA profiling: A better miR trap

October 20th, 2015 by Terry L Sheppard

Nature Chemical Biology 11, 828 (2015). doi:10.1038/nchembio.1942

Author: Terry L Sheppard

Microbiology: Membranes get the gold

October 20th, 2015 by Mirella Bucci

Nature Chemical Biology 11, 829 (2015). doi:10.1038/nchembio.1946

Author: Mirella Bucci

Antibiotics: Synergistic MRSA combinations

October 20th, 2015 by Karen Bush

Nature Chemical Biology 11, 832 (2015). doi:10.1038/nchembio.1935

Author: Karen Bush

Meropenem/piperacillin/tazobactam is a triple β-lactam combination that kills MRSA in vitro and in a mouse model through a novel synergistic mechanism of action. Similar activity for other carbapenem/β-lactam combinations suggests that MRSA infections might be treatable with combinations of established β-lactams currently classified as ineffective against MRSA.

Corrigendum: The promise and peril of chemical probes

October 20th, 2015 by Cheryl H Arrowsmith

Nature Chemical Biology 11, 887 (2015). doi:10.1038/nchembio1115-887c

Author: Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Mathias Frederiksen, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C O'Hagan, John P Overington, Dafydd R Owen, Saul H Rosenberg, Ruth Ross, Bryan Roth, Matthieu Schapira, Stuart L Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A Walters, Timothy M Willson, Paul Workman, Robert N Young & William J Zuercher

Metabolism: Plugging the leak

October 20th, 2015 by Bryan C Dickinson

Nature Chemical Biology 11, 831 (2015). doi:10.1038/nchembio.1934

Author: Bryan C Dickinson

Multiple mitochondrial components generate reactive oxygen species (ROS), but separating the consequences of each ROS-generating source from overall mitochondrial health is challenging. A new class of small-molecule inhibitors that selectively block ROS generation from one of the most active sources may provide a new approach toward achieving that goal.

Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching

October 19th, 2015 by Srividhya Sundaram

Nature Chemical Biology 11, 949 (2015). doi:10.1038/nchembio.1932

Authors: Srividhya Sundaram, Daniel Heine & Christian Hertweck

Biosynthesis of rhizoxin in Burkholderia rhizoxinica affords an unusual polyketide synthase module with ketosynthase and branching domains that install the δ-lactone, conferring antimitotic activity. To investigate their functions in chain branching, we designed chimeric modules with structurally similar domains from a glutarimide-forming module and a dehydratase. Biochemical, kinetic and mutational analyses reveal a structural role of the accessory domains and multifarious catalytic actions of the ketosynthase.

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Chemical libraries: How dark is HTS dark matter?

October 19th, 2015 by Ricardo Macarron

Nature Chemical Biology 11, 904 (2015). doi:10.1038/nchembio.1937

Author: Ricardo Macarron

Selecting compounds for the chemical library is the foundation of high-throughput screening (HTS). After some years and multiple HTS campaigns, many molecules in the Novartis and NIH Molecular Libraries Program screening collections have never been found to be active. An in-depth exploration of the bioactivity of this 'dark matter' does in fact reveal some compounds of interest.