A CRISPR screen identifies a pathway required for paraquat-induced cell death

October 23rd, 2017 by Colleen R Reczek

A CRISPR screen identifies a pathway required for paraquat-induced cell death

A CRISPR screen identifies a pathway required for paraquat-induced cell death, Published online: 23 October 2017; doi:10.1038/nchembio.2499

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A positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

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Ubiquitin biology: Unraveling the chain

October 18th, 2017 by Grant Miura

Ubiquitin biology: Unraveling the chain

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2508

Bacterial cell wall: Phages breaking free

October 18th, 2017 by Karin Kuehnel

Bacterial cell wall: Phages breaking free

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2506

Biomaterials: Cotton gets superpowers

October 18th, 2017 by Caitlin Deane

Biomaterials: Cotton gets superpowers

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2505

Host-microbe interactions: Aiming at GPCRs

October 18th, 2017 by Mirella Bucci

Host-microbe interactions: Aiming at GPCRs

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2507

Drug discovery: Controlling protein SUMOylation

October 18th, 2017 by John S Schneekloth Jr

Drug discovery: Controlling protein SUMOylation

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2496

A potent and selective inhibitor of protein SUMOylation, a ubiquitin-like post-translational modification, has been developed, shedding light on the potential for developing new classes of anticancer therapeutics.

Corrigendum: Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis

September 19th, 2017 by Karine Bastard

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137c

Author: Karine Bastard, Alain Perret, Aline Mariage, Thomas Bessonnet, Agnès Pinet-Turpault, Jean-Louis Petit, Ekaterina Darii, Pascal Bazire, Carine Vergne-Vaxelaire, Clémence Brewee, Adrien Debard, Virginie Pellouin, Marielle Besnard-Gonnet, François Artiguenave, Claudine Médigue, David Vallenet, Antoine Danchin, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat & Véronique de Berardinis

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Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

September 19th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137b

Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

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Chemical methods: DREADDs see no CNO

September 19th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2483

Author: Mirella Bucci

Protein engineering: Expanding splicing versatility

September 19th, 2017 by Karin Kuehnel

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2485

Author: Karin Kuehnel