The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

June 18th, 2018 by Vincent Wiebach

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides, Published online: 18 June 2018; doi:10.1038/s41589-018-0068-6

The antibacterial microvionin contains two new lanthipeptide modifications, a triamino-dicarboxylic acid (avionin) and an N-terminal guanidino fatty acid, that lead to the establishment of the lipolanthine natural product class.
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The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases

June 18th, 2018 by Suzana Markolovic

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases, Published online: 18 June 2018; doi:10.1038/s41589-018-0071-y

Structural, biochemical and cellular studies reveal JMJD7 to be a Jumonji-C oxygenase that catalyzes (3S)-lysyl hydroxylation of the translation factor family of GTPases, DRG1 and DRG2.
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Vitamin B<sub>12</sub> import is all about timing

June 18th, 2018 by Lutz Schmitt

Vitamin B12 import is all about timing

Vitamin B<sub>12</sub> import is all about timing, Published online: 18 June 2018; doi:10.1038/s41589-018-0087-3

Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

Please hold for chaperones

June 18th, 2018 by Caitlin Deane

Please hold for chaperones

Please hold for chaperones, Published online: 18 June 2018; doi:10.1038/s41589-018-0092-6

Please hold for chaperones

Plasticity in binding confers selectivity in ligand-induced protein degradation

June 11th, 2018 by Radosław P. Nowak

Plasticity in binding confers selectivity in ligand-induced protein degradation

Plasticity in binding confers selectivity in ligand-induced protein degradation, Published online: 11 June 2018; doi:10.1038/s41589-018-0055-y

Selectivity of ligand-induced protein degradation and dimerization is conferred by plastic interprotein contacts. Computational protein–protein docking reveals the underlying interprotein contacts to inform the design of a BRD4 selective degrader.
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Linkers for protein degradation

June 11th, 2018 by Philip P. Chamberlain

Linkers for protein degradation

Linkers for protein degradation, Published online: 11 June 2018; doi:10.1038/s41589-018-0057-9

The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern

June 11th, 2018 by Benoit Castrec

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern, Published online: 11 June 2018; doi:10.1038/s41589-018-0077-5

Aided by the solving of the structures of human NMT1 with substrate-mimicking peptides, mapping of human and Arabidopsis myristoylomes defines a myristoylation recognition motif and over 1,000 myristoylated protein targets.
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Functional assignment of multiple catabolic pathways for <span class=”small-caps”>d</span>-apiose

June 4th, 2018 by Michael S. Carter

Functional assignment of multiple catabolic pathways for d-apiose

Functional assignment of multiple catabolic pathways for <span class="small-caps">d</span>-apiose, Published online: 04 June 2018; doi:10.1038/s41589-018-0067-7

A bioinformatic strategy beginning with solute-binding proteins involved in sugar transport led to the functional annotation of four previously unknown catabolic pathways of the branched pentose d-apiose.
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Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

June 4th, 2018 by Jianchao Li

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins, Published online: 04 June 2018; doi:10.1038/s41589-018-0082-8

Potent pan-Atg8 or GABARAP-selective inhibitory peptides derived from giant neuronal ankyrin-B and -G effectively block autophagy in cell cultures and in C. elegans spatiotemporally.
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Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

June 4th, 2018 by Nan Wang

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme, Published online: 04 June 2018; doi:10.1038/s41589-018-0061-0

Functional and structural characterization of PtmA2 reveals that it is an unusual non-adenylating acyl-CoA ligase and part of a system wherein the canonical acyl-CoA ligase reaction is separated into two half-reactions performed by distinct enzymes.
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