Functional annotation of chemical libraries across diverse biological processes

July 24th, 2017 by Jeff S Piotrowski

Nature Chemical Biology 13, 982 (2017). doi:10.1038/nchembio.2436

Authors: Jeff S Piotrowski, Sheena C Li, Raamesh Deshpande, Scott W Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A Gebre, Karen Kubo, Nikko P Torres, Marissa A LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L Myers & Charles Boone

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Copper import in Escherichia coli by the yersiniabactin metallophore system

July 24th, 2017 by Eun-Ik Koh

Nature Chemical Biology 13, 1016 (2017). doi:10.1038/nchembio.2441

Authors: Eun-Ik Koh, Anne E Robinson, Nilantha Bandara, Buck E Rogers & Jeffrey P Henderson

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Enzymology: Tracking off-targets

July 18th, 2017 by Alison Farrell

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2445

Author: Alison Farrell

Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

July 18th, 2017 by Yupeng He

Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922b

Author: Yupeng He, Sujatha Selvaraju, Michael L Curtin, Clarissa G Jakob, Haizhong Zhu, Kenneth M Comess, Bailin Shaw, Juliana The, Evelyne Lima-Fernandes, Magdalena M Szewczyk, Dong Cheng, Kelly L Klinge, Huan-Qiu Li, Marina Pliushchev, Mikkel A Algire, David Maag, Jun Guo, Justin Dietrich, Sanjay C Panchal, Andrew M Petros, Ramzi F Sweis, Maricel Torrent, Lance J Bigelow, Guillermo Senisterra, Fengling Li, Steven Kennedy, Qin Wu, Donald J Osterling, David J Lindley, Wenqing Gao, Scott Galasinski, Dalia Barsyte-Lovejoy, Masoud Vedadi, Fritz G Buchanan, Cheryl H Arrowsmith, Gary G Chiang, Chaohong Sun & William N Pappano

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Antibacterials: PUMmeling RNAP

July 18th, 2017 by Terry L. Sheppard

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2446

Author: Terry L. Sheppard

Erratum: Structural and conformational determinants of macrocycle cell permeability

July 18th, 2017 by Björn Over

Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922a

Author: Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall & Jan Kihlberg

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Biocatalysis: Achieving aminase activity

July 18th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2447

Author: Caitlin Deane

Harnessing yeast organelles for metabolic engineering

July 18th, 2017 by Sarah K Hammer

Nature Chemical Biology 13, 823 (2017). doi:10.1038/nchembio.2429

Authors: Sarah K Hammer & José L Avalos

Structural biology: Full monty of family B GPCRs

July 18th, 2017 by Thue W Schwartz

Nature Chemical Biology 13, 819 (2017). doi:10.1038/nchembio.2438

Authors: Thue W Schwartz & Thomas M Frimurer

New structures of the glucagon-like peptide-1 (GLP-1) and glucagon receptors in complex with peptide and nonpeptide ligands provide a comprehensive, detailed picture of the molecular mechanisms of action of family B GPCRs. This opens the door for true structure-based drug discovery aimed at both novel orthosteric and allosteric subsites of the receptors.

Hints of hidden chemistry

July 18th, 2017 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 13, 815 (2017). doi:10.1038/nchembio.2449

Biosynthetic pathways harbor diverse enzyme functions, and identifying those that catalyze unusual or synthetically challenging transformations offers new routes for biocatalytic development.