Riboswitches: A bacterial antivitamin

November 17th, 2015 by Terry L. Sheppard

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1973

Author: Terry L. Sheppard

Chemical modulators of ribosome biogenesis as biological probes

November 17th, 2015 by Jonathan M Stokes

Nature Chemical Biology 11, 924 (2015). doi:10.1038/nchembio.1957

Authors: Jonathan M Stokes & Eric D Brown

Voices of chemical biology

November 17th, 2015 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 11, 900 (2015). doi:10.1038/nchembio.1975

We asked a collection of chemical biologists: “What is the most exciting frontier area in chemical biology, and what key technology is needed to advance knowledge and applications at this frontier?”

Functional genomics to uncover drug mechanism of action

November 17th, 2015 by Sebastian M B Nijman

Nature Chemical Biology 11, 942 (2015). doi:10.1038/nchembio.1963

Author: Sebastian M B Nijman

Metabolism: Some assembly required

November 17th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1974

Author: Catherine Goodman

Tumor immunology: Assembling the T cell

November 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1969

Author: Grant Miura

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

November 16th, 2015 by Courtney R Green

Nature Chemical Biology 12, 15 (2016). doi:10.1038/nchembio.1961

Authors: Courtney R Green, Martina Wallace, Ajit S Divakaruni, Susan A Phillips, Anne N Murphy, Theodore P Ciaraldi & Christian M Metallo

  • Posted in Nat Chem Biol, Publications
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Allosteric regulation of G protein–coupled receptor activity by phospholipids

November 16th, 2015 by Rosie Dawaliby

Nature Chemical Biology 12, 35 (2016). doi:10.1038/nchembio.1960

Authors: Rosie Dawaliby, Cataldo Trubbia, Cédric Delporte, Matthieu Masureel, Pierre Van Antwerpen, Brian K Kobilka & Cédric Govaerts

  • Posted in Nat Chem Biol, Publications
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Structural determinants of reductive terpene cyclization in iridoid biosynthesis

November 9th, 2015 by Hajo Kries

Nature Chemical Biology 12, 6 (2016). doi:10.1038/nchembio.1955

Authors: Hajo Kries, Lorenzo Caputi, Clare E M Stevenson, Mohammed O Kamileen, Nathaniel H Sherden, Fernando Geu-Flores, David M Lawson & Sarah E O'Connor

The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5β-reductase are highlighted.

  • Posted in Nat Chem Biol, Publications
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Class D β-lactamases do exist in Gram-positive bacteria

November 9th, 2015 by Marta Toth

Nature Chemical Biology 12, 9 (2016). doi:10.1038/nchembio.1950

Authors: Marta Toth, Nuno Tiago Antunes, Nichole K Stewart, Hilary Frase, Monolekha Bhattacharya, Clyde A Smith & Sergei B Vakulenko