A transcription activator–like effector (TALE) induction system mediated by proteolysis

February 8th, 2016 by Matthew F Copeland

Nature Chemical Biology 12, 254 (2016). doi:10.1038/nchembio.2021

Authors: Matthew F Copeland, Mark C Politz, Charles B Johnson, Andrew L Markley & Brian F Pfleger

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A transcription activator–like effector (TALE) induction system mediated by proteolysis

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

February 8th, 2016 by Jessika Valero-González

Nature Chemical Biology 12, 240 (2016). doi:10.1038/nchembio.2019

Authors: Jessika Valero-González, Christina Leonhard-Melief, Erandi Lira-Navarrete, Gonzalo Jiménez-Osés, Cristina Hernández-Ruiz, María Carmen Pallarés, Inmaculada Yruela, Deepika Vasudevan, Anabel Lostao, Francisco Corzana, Hideyuki Takeuchi, Robert S Haltiwanger & Ramon Hurtado-Guerrero

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

Engineering nonphosphorylative metabolism to generate lignocellulose-derived products

February 8th, 2016 by Yi-Shu Tai

Nature Chemical Biology 12, 247 (2016). doi:10.1038/nchembio.2020

Authors: Yi-Shu Tai, Mingyong Xiong, Pooja Jambunathan, Jingyu Wang, Jilong Wang, Cole Stapleton & Kechun Zhang

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Engineering nonphosphorylative metabolism to generate lignocellulose-derived products

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

February 1st, 2016 by Fei Mo

Nature Chemical Biology 12, 226 (2016). doi:10.1038/nchembio.2017

Authors: Fei Mo, Xiaoxuan Zhuang, Xing Liu, Phil Y Yao, Bo Qin, Zeqi Su, Jianye Zang, Zhiyong Wang, Jiancun Zhang, Zhen Dou, Changlin Tian, Maikun Teng, Liwen Niu, Donald L Hill, Guowei Fang, Xia Ding, Chuanhai Fu & Xuebiao Yao

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

February 1st, 2016 by Panayotis C Theodoropoulos

Nature Chemical Biology 12, 218 (2016). doi:10.1038/nchembio.2016

Authors: Panayotis C Theodoropoulos, Stephen S Gonzales, Sarah E Winterton, Carlos Rodriguez-Navas, John S McKnight, Lorraine K Morlock, Jordan M Hanson, Bethany Cross, Amy E Owen, Yingli Duan, Jose R Moreno, Andrew Lemoff, Hamid Mirzaei, Bruce A Posner, Noelle S Williams, Joseph M Ready & Deepak Nijhawan

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Assembly and clustering of natural antibiotics guides target identification

February 1st, 2016 by Chad W Johnston

Nature Chemical Biology 12, 233 (2016). doi:10.1038/nchembio.2018

Authors: Chad W Johnston, Michael A Skinnider, Chris A Dejong, Philip N Rees, Gregory M Chen, Chelsea G Walker, Shawn French, Eric D Brown, János Bérdy, Dennis Y Liu & Nathan A Magarvey

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Assembly and clustering of natural antibiotics guides target identification

A pyridoxal phosphate–dependent enzyme that oxidizes an unactivated carbon-carbon bond

January 25th, 2016 by Yi-Ling Du

Nature Chemical Biology 12, 194 (2016). doi:10.1038/nchembio.2009

Authors: Yi-Ling Du, Rahul Singh, Lona M Alkhalaf, Eugene Kuatsjah, Hai-Yan He, Lindsay D Eltis & Katherine S Ryan

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A pyridoxal phosphate–dependent enzyme that oxidizes an unactivated carbon-carbon bond

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

January 25th, 2016 by Jacob I Stuckey

Nature Chemical Biology 12, 180 (2016). doi:10.1038/nchembio.2007

Authors: Jacob I Stuckey, Bradley M Dickson, Nancy Cheng, Yanli Liu, Jacqueline L Norris, Stephanie H Cholensky, Wolfram Tempel, Su Qin, Katherine G Huber, Cari Sagum, Karynne Black, Fengling Li, Xi-Ping Huang, Bryan L Roth, Brandi M Baughman, Guillermo Senisterra, Samantha G Pattenden, Masoud Vedadi, Peter J Brown, Mark T Bedford, Jinrong Min, Cheryl H Arrowsmith, Lindsey I James & Stephen V Frye

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

A two-state activation mechanism controls the histone methyltransferase Suv39h1

January 25th, 2016 by Manuel M Müller

Nature Chemical Biology 12, 188 (2016). doi:10.1038/nchembio.2008

Authors: Manuel M Müller, Beat Fierz, Lenka Bittova, Glen Liszczak & Tom W Muir

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A two-state activation mechanism controls the histone methyltransferase Suv39h1

Metalloenzymes: Getting the gold

January 19th, 2016 by Catherine Goodman

Nature Chemical Biology 12, 53 (2016). doi:10.1038/nchembio.2014

Author: Catherine Goodman