Metals: A hydride out of hiding

November 17th, 2015 by Catherine Goodman

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1971

Author: Catherine Goodman

RNA folding: A clear path to RNA catalysis

November 17th, 2015 by Amanda Solem

Nature Chemical Biology 11, 906 (2015). doi:10.1038/nchembio.1954

Authors: Amanda Solem & Alain Laederach

A new high-resolution crystal structure of the subdomain from a catalytically active group II intron reveals important conformational rearrangements necessary to achieve the fully formed catalyst. This structure provides the first atomic-resolution structure of an RNA folding intermediate.

Progress and challenges for chemical probing of RNA structure inside living cells

November 17th, 2015 by Miles Kubota

Nature Chemical Biology 11, 933 (2015). doi:10.1038/nchembio.1958

Authors: Miles Kubota, Catherine Tran & Robert C Spitale

  • Posted in Nat Chem Biol, Publications
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RNA modification: Stressing the message

November 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 903 (2015). doi:10.1038/nchembio.1970

Author: Grant Miura

Imaging and manipulating proteins in live cells through covalent labeling

November 17th, 2015 by Lin Xue

Nature Chemical Biology 11, 917 (2015). doi:10.1038/nchembio.1959

Authors: Lin Xue, Iuliia A Karpenko, Julien Hiblot & Kai Johnsson

  • Posted in Nat Chem Biol, Publications
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Targeting transcription is no longer a quixotic quest

November 17th, 2015 by Anna K Mapp

Nature Chemical Biology 11, 891 (2015). doi:10.1038/nchembio.1962

Authors: Anna K Mapp, Rachel Pricer & Steven Sturlis

Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.

Virology: MicroRNA-lipid one-upmanship

November 17th, 2015 by Patricia A Thibault

Nature Chemical Biology 11, 905 (2015). doi:10.1038/nchembio.1953

Authors: Patricia A Thibault & Joyce A Wilson

25-Hydroxycholesterol induces miR-185 to suppress lipid and cholesterol synthesis pathways and inhibit viruses such as hepatitis C virus (HCV), that use host membranes to propagate. HCV counteracts this by suppressing miR-185 expression to drive increased cellular lipid content.

Intrinsically disordered proteins: I like to move it, move it

November 17th, 2015 by Joshua M. Finkelstein

Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1972

Author: Joshua M. Finkelstein

Discovery and characterization of smORF-encoded bioactive polypeptides

November 17th, 2015 by Alan Saghatelian

Nature Chemical Biology 11, 909 (2015). doi:10.1038/nchembio.1964

Authors: Alan Saghatelian & Juan Pablo Couso

  • Posted in Nat Chem Biol, Publications
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XFELs open a new era in structural chemical biology

November 17th, 2015 by Petra Fromme

Nature Chemical Biology 11, 895 (2015). doi:10.1038/nchembio.1968

Author: Petra Fromme

X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method's great potential to make new structural discoveries, such as the ability to generate molecular movies of biomolecules at work.