A reactivity-based probe of the intracellular labile ferrous iron pool

July 4th, 2016 by Benjamin Spangler

Nature Chemical Biology 12, 680 (2016). doi:10.1038/nchembio.2116

Authors: Benjamin Spangler, Charles W Morgan, Shaun D Fontaine, Mark N Vander Wal, Christopher J Chang, James A Wells & Adam R Renslo

  • Posted in Nat Chem Biol, Publications
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Tbx16 regulates hox gene activation in mesodermal progenitor cells

July 4th, 2016 by Alexander Y Payumo

Nature Chemical Biology 12, 694 (2016). doi:10.1038/nchembio.2124

Authors: Alexander Y Payumo, Lindsey E McQuade, Whitney J Walker, Sayumi Yamazoe & James K Chen

Loss of protein association causes cardiolipin degradation in Barth syndrome

June 27th, 2016 by Yang Xu

Nature Chemical Biology 12, 641 (2016). doi:10.1038/nchembio.2113

Authors: Yang Xu, Colin K L Phoon, Bob Berno, Kenneth D'Souza, Esthelle Hoedt, Guoan Zhang, Thomas A Neubert, Richard M Epand, Mindong Ren & Michael Schlame

  • Posted in Nat Chem Biol, Publications
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Precursors of tRNAs are stabilized by methylguanosine cap structures

June 27th, 2016 by Takayuki Ohira

Nature Chemical Biology 12, 648 (2016). doi:10.1038/nchembio.2117

Authors: Takayuki Ohira & Tsutomu Suzuki

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

June 27th, 2016 by Andrew J Mitchell

Nature Chemical Biology 12, 636 (2016). doi:10.1038/nchembio.2112

Authors: Andrew J Mitchell, Qin Zhu, Ailiena O Maggiolo, Nikhil R Ananth, Matthew L Hillwig, Xinyu Liu & Amie K Boal

  • Posted in Nat Chem Biol, Publications
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Identifying the functional contribution of the defatty-acylase activity of SIRT6

June 20th, 2016 by Xiaoyu Zhang

Nature Chemical Biology 12, 614 (2016). doi:10.1038/nchembio.2106

Authors: Xiaoyu Zhang, Saba Khan, Hong Jiang, Marc A Antonyak, Xiao Chen, Nicole A Spiegelman, Jonathan H Shrimp, Richard A Cerione & Hening Lin

  • Posted in Nat Chem Biol, Publications
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A family of metal-dependent phosphatases implicated in metabolite damage-control

June 20th, 2016 by Lili Huang

Nature Chemical Biology 12, 621 (2016). doi:10.1038/nchembio.2108

Authors: Lili Huang, Anna Khusnutdinova, Boguslaw Nocek, Greg Brown, Xiaohui Xu, Hong Cui, Pierre Petit, Robert Flick, Rémi Zallot, Kelly Balmant, Michael J Ziemak, John Shanklin, Valérie de Crécy-Lagard, Oliver Fiehn, Jesse F Gregory, Andrzej Joachimiak, Alexei Savchenko, Alexander F Yakunin & Andrew D Hanson

  • Posted in Nat Chem Biol, Publications
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Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

June 20th, 2016 by Andrea Schulze

Nature Chemical Biology 12, 628 (2016). doi:10.1038/nchembio.2111

Authors: Andrea Schulze, Gerti Beliu, Dominic A Helmerich, Jonathan Schubert, Laurence H Pearl, Chrisostomos Prodromou & Hannes Neuweiler

  • Posted in Nat Chem Biol, Publications
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Chemical genetics: Unraveling cell death mysteries

June 17th, 2016 by Xiomaris M Cotto-Rios

Nature Chemical Biology 12, 470 (2016). doi:10.1038/nchembio.2110

Authors: Xiomaris M Cotto-Rios & Evripidis Gavathiotis

Non-apoptotic regulated cell death is not fully characterized, particularly for ferroptosis, the iron- and ROS-dependent form of regulated cell death. A systematic approach using modulatory profiling and cell line sensitivity analysis has unraveled the association of lipid metabolism with ferroptosis and enabled the discovery of a novel specific ferroptosis inducer.

Antibiotic discovery: Macrolides en masse

June 17th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2120

Author: Caitlin Deane