Protein evolution: Polymerase’s new language

May 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2094

Author: Caitlin Deane

Proteostasis: Chaperoning for hearing loss

May 18th, 2016 by Gergely L Lukacs

Nature Chemical Biology 12, 388 (2016). doi:10.1038/nchembio.2091

Author: Gergely L Lukacs

A small molecule has been identified that can mitigate the progression of an inherited form of deafness in transgenic mice by stabilizing mutant clarin-1, an essential component of a multimolecular complex of the mechanotransduction apparatus of hair cells in the inner ear.

Metalloproteins: Mapping elusive electron density

May 18th, 2016 by Louis Noodleman

Nature Chemical Biology 12, 391 (2016). doi:10.1038/nchembio.2088

Author: Louis Noodleman

Iron–sulfur metalloproteins are critical for electron transfer in bacterial metabolism, but most crystal structures are insufficient for their in-depth study. Now, acquisition of an iron–sulfur protein structure at ultra-high resolution enables detailed visualization of its electron distribution.

Cancer metabolism: Addicted to serine

May 18th, 2016 by Christian Frezza

Nature Chemical Biology 12, 389 (2016). doi:10.1038/nchembio.2086

Author: Christian Frezza

Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors selectively block proliferation of PHGDH-dependent cancer cells and reveal an unexpected role of serine biosynthesis in coordinating one-carbon metabolism.

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

May 16th, 2016 by Ting Han

Nature Chemical Biology 12, 511 (2016). doi:10.1038/nchembio.2082

Authors: Ting Han, Maria Goralski, Emanuela Capota, Shae B Padrick, Jiwoong Kim, Yang Xie & Deepak Nijhawan

A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

May 16th, 2016 by Monique P C Mulder

Nature Chemical Biology 12, 523 (2016). doi:10.1038/nchembio.2084

Authors: Monique P C Mulder, Katharina Witting, Ilana Berlin, Jonathan N Pruneda, Kuen-Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C O Vertegaal, Brenda A Schulman, David Komander, Jacques Neefjes, Farid El Oualid & Huib Ovaa

  • Posted in Nat Chem Biol, Publications
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Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

May 16th, 2016 by Lisandro J González

Nature Chemical Biology 12, 516 (2016). doi:10.1038/nchembio.2083

Authors: Lisandro J González, Guillermo Bahr, Toshiki G Nakashige, Elizabeth M Nolan, Robert A Bonomo & Alejandro J Vila

  • Posted in Nat Chem Biol, Publications
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Prdm4 induction by the small molecule butein promotes white adipose tissue browning

May 9th, 2016 by No-Joon Song

Nature Chemical Biology 12, 479 (2016). doi:10.1038/nchembio.2081

Authors: No-Joon Song, Seri Choi, Prashant Rajbhandari, Seo-Hyuk Chang, Suji Kim, Laurent Vergnes, So-Mi Kwon, Jung-Hoon Yoon, Sukchan Lee, Jin-Mo Ku, Jeong-Soo Lee, Karen Reue, Seung-Hoi Koo, Peter Tontonoz & Kye Won Park

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

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Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

May 9th, 2016 by Sara Sdelci

Nature Chemical Biology 12, 504 (2016). doi:10.1038/nchembio.2080

Authors: Sara Sdelci, Charles-Hugues Lardeau, Cynthia Tallant, Freya Klepsch, Björn Klaiber, James Bennett, Philipp Rathert, Michael Schuster, Thomas Penz, Oleg Fedorov, Giulio Superti-Furga, Christoph Bock, Johannes Zuber, Kilian V M Huber, Stefan Knapp, Susanne Müller & Stefan Kubicek

  • Posted in Nat Chem Biol, Publications
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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

May 9th, 2016 by Kenichi Shimada

Nature Chemical Biology 12, 497 (2016). doi:10.1038/nchembio.2079

Authors: Kenichi Shimada, Rachid Skouta, Anna Kaplan, Wan Seok Yang, Miki Hayano, Scott J Dixon, Lewis M Brown, Carlos A Valenzuela, Adam J Wolpaw & Brent R Stockwell

  • Posted in Nat Chem Biol, Publications
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