An in vivo platform for identifying inhibitors of protein aggregation

December 14th, 2015 by Janet C Saunders

Nature Chemical Biology 12, 94 (2016). doi:10.1038/nchembio.1988

Authors: Janet C Saunders, Lydia M Young, Rachel A Mahood, Matthew P Jackson, Charlotte H Revill, Richard J Foster, D Alastair Smith, Alison E Ashcroft, David J Brockwell & Sheena E Radford

  • Posted in Nat Chem Biol, Publications
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High-throughput analysis and protein engineering using microcapillary arrays

December 7th, 2015 by Bob Chen

Nature Chemical Biology 12, 76 (2016). doi:10.1038/nchembio.1978

Authors: Bob Chen, Sungwon Lim, Arvind Kannan, Spencer C Alford, Fanny Sunden, Daniel Herschlag, Ivan K Dimov, Thomas M Baer & Jennifer R Cochran

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‘Deadman’ and ‘Passcode’ microbial kill switches for bacterial containment

December 7th, 2015 by Clement T Y Chan

Nature Chemical Biology 12, 82 (2016). doi:10.1038/nchembio.1979

Authors: Clement T Y Chan, Jeong Wook Lee, D Ewen Cameron, Caleb J Bashor & James J Collins

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Protein engineering: Beating the odds

December 7th, 2015 by Uwe T Bornscheuer

Nature Chemical Biology 12, 54 (2016). doi:10.1038/nchembio.1989

Author: Uwe T Bornscheuer

Recently developed advanced microfluidics-based systems have outperformed known screening tools with respect to throughput, flexibility, sensitivity and tricks for hit recovery. This has enabled the discovery of novel and improved proteins from random mutagenesis libraries or metagenome-based sources.

Molecular mechanism of respiratory syncytial virus fusion inhibitors

December 7th, 2015 by Michael B Battles

Nature Chemical Biology 12, 87 (2016). doi:10.1038/nchembio.1982

Authors: Michael B Battles, Johannes P Langedijk, Polina Furmanova-Hollenstein, Supranee Chaiwatpongsakorn, Heather M Costello, Leen Kwanten, Luc Vranckx, Paul Vink, Steffen Jaensch, Tim H M Jonckers, Anil Koul, Eric Arnoult, Mark E Peeples, Dirk Roymans & Jason S McLellan

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

November 30th, 2015 by Lincoln Pasquina

Nature Chemical Biology 12, 40 (2016). doi:10.1038/nchembio.1967

Authors: Lincoln Pasquina, John P Santa Maria, B McKay Wood, Samir H Moussa, Leigh M Matano, Marina Santiago, Sara E S Martin, Wonsik Lee, Timothy C Meredith & Suzanne Walker

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Mechanism of hydrogen activation by [NiFe] hydrogenases

November 30th, 2015 by Rhiannon M Evans

Nature Chemical Biology 12, 46 (2016). doi:10.1038/nchembio.1976

Authors: Rhiannon M Evans, Emily J Brooke, Sara A M Wehlin, Elena Nomerotskaia, Frank Sargent, Stephen B Carr, Simon E V Phillips & Fraser A Armstrong

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

November 23rd, 2015 by Po-Ssu Huang

Nature Chemical Biology 12, 29 (2016). doi:10.1038/nchembio.1966

Authors: Po-Ssu Huang, Kaspar Feldmeier, Fabio Parmeggiani, D Alejandro Fernandez Velasco, Birte Höcker & David Baker

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CRISPR-Cas9–based target validation for p53-reactivating model compounds

November 23rd, 2015 by Michael Wanzel

Nature Chemical Biology 12, 22 (2016). doi:10.1038/nchembio.1965

Authors: Michael Wanzel, Jonas B Vischedyk, Miriam P Gittler, Niklas Gremke, Julia R Seiz, Mirjam Hefter, Magdalena Noack, Rajkumar Savai, Marco Mernberger, Joël P Charles, Jean Schneikert, Anne Catherine Bretz, Andrea Nist & Thorsten Stiewe

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Tumor immunology: Assembling the T cell

November 17th, 2015 by Grant Miura

Nature Chemical Biology 11, 902 (2015). doi:10.1038/nchembio.1969

Author: Grant Miura