Identifying the functional contribution of the defatty-acylase activity of SIRT6

June 20th, 2016 by Xiaoyu Zhang

Nature Chemical Biology 12, 614 (2016). doi:10.1038/nchembio.2106

Authors: Xiaoyu Zhang, Saba Khan, Hong Jiang, Marc A Antonyak, Xiao Chen, Nicole A Spiegelman, Jonathan H Shrimp, Richard A Cerione & Hening Lin

  • Posted in Nat Chem Biol, Publications
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A family of metal-dependent phosphatases implicated in metabolite damage-control

June 20th, 2016 by Lili Huang

Nature Chemical Biology 12, 621 (2016). doi:10.1038/nchembio.2108

Authors: Lili Huang, Anna Khusnutdinova, Boguslaw Nocek, Greg Brown, Xiaohui Xu, Hong Cui, Pierre Petit, Robert Flick, Rémi Zallot, Kelly Balmant, Michael J Ziemak, John Shanklin, Valérie de Crécy-Lagard, Oliver Fiehn, Jesse F Gregory, Andrzej Joachimiak, Alexei Savchenko, Alexander F Yakunin & Andrew D Hanson

  • Posted in Nat Chem Biol, Publications
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Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

June 20th, 2016 by Andrea Schulze

Nature Chemical Biology 12, 628 (2016). doi:10.1038/nchembio.2111

Authors: Andrea Schulze, Gerti Beliu, Dominic A Helmerich, Jonathan Schubert, Laurence H Pearl, Chrisostomos Prodromou & Hannes Neuweiler

  • Posted in Nat Chem Biol, Publications
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Ion channels: Calcium channels work together

June 17th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2123

Author: Mirella Bucci

Chemical genetics: Unraveling cell death mysteries

June 17th, 2016 by Xiomaris M Cotto-Rios

Nature Chemical Biology 12, 470 (2016). doi:10.1038/nchembio.2110

Authors: Xiomaris M Cotto-Rios & Evripidis Gavathiotis

Non-apoptotic regulated cell death is not fully characterized, particularly for ferroptosis, the iron- and ROS-dependent form of regulated cell death. A systematic approach using modulatory profiling and cell line sensitivity analysis has unraveled the association of lipid metabolism with ferroptosis and enabled the discovery of a novel specific ferroptosis inducer.

Antibiotic discovery: Macrolides en masse

June 17th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2120

Author: Caitlin Deane

Progress and prospects for small-molecule probes of bacterial imaging

June 17th, 2016 by Ozden Kocaoglu

Nature Chemical Biology 12, 472 (2016). doi:10.1038/nchembio.2109

Authors: Ozden Kocaoglu & Erin E Carlson

  • Posted in Nat Chem Biol, Publications
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RNA structure: PARISian arches

June 17th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2121

Author: Terry L. Sheppard

Chromatin targeting: A BET inhibitor workaround

June 17th, 2016 by Christopher J Burns

Nature Chemical Biology 12, 469 (2016). doi:10.1038/nchembio.2107

Author: Christopher J Burns

A phenotypic cell-based screen identifies an inhibitor of BET bromodomain transcriptional activity via inhibition of the alternative bromodomain-containing protein TAF1.

Methanogenesis: A radical approach

June 17th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2122

Author: Caitlin Deane