Cell division: TIPs for shaping Aurora B activity

March 18th, 2016 by George Zachos

Nature Chemical Biology 12, 204 (2016). doi:10.1038/nchembio.2041

Author: George Zachos

Cdk1 links mitotic entry to faithful chromosome segregation by activating the acetyltransferase TIP60. Acetylation of Aurora B kinase by TIP60 protects Aurora B's activation loop from dephosphorylation by the PP2A phosphatase to ensure robust Aurora B activation.

Erratum: February 2016 cover caption

March 18th, 2016 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 12, 304 (2016). doi:10.1038/nchembio0416-304a

Corrigendum: Frequency and amplitude control of cortical oscillations by phosphoinositide waves

March 18th, 2016 by Ding Xiong

Nature Chemical Biology 12, 304 (2016). doi:10.1038/nchembio0416-304b

Author: Ding Xiong, Shengping Xiao, Su Guo, Qingsong Lin, Fubito Nakatsu & Min Wu

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Toxin-antitoxin systems in bacterial growth arrest and persistence

March 18th, 2016 by Rebecca Page

Nature Chemical Biology 12, 208 (2016). doi:10.1038/nchembio.2044

Authors: Rebecca Page & Wolfgang Peti

Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

March 18th, 2016 by James Palacino

Nature Chemical Biology 12, 304 (2016). doi:10.1038/nchembio0416-304c

Author: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline Bullock, Michael McLellan, Sven Schuierer, Leo Murphy, Marcel J J Blommers, Cecile Blaustein, Frada Berenshteyn, Arnaud Lacoste, Jason R Thomas, Guglielmo Roma, Gregory A Michaud, Brian S Tseng, Jeffery A Porter, Vic E Myer, John A Tallarico, Lawrence G Hamann,, Daniel Curtis, Mark C Fishman, William F Dietrich, Natalie A Dales & Rajeev Sivasankaran

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Drug discovery: One without the other

March 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2055

Author: Mirella Bucci

Transcription: 7SK’s enhanced roles

March 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2053

Author: Terry L. Sheppard

Signal transduction: Lowered exchange rates

March 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 201 (2016). doi:10.1038/nchembio.2054

Author: Grant Miura

Methyl-esterified 3-hydroxybutyrate oligomers protect bacteria from hydroxyl radicals

March 14th, 2016 by Janne J Koskimäki

Nature Chemical Biology 12, 332 (2016). doi:10.1038/nchembio.2043

Authors: Janne J Koskimäki, Marena Kajula, Juho Hokkanen, Emmi-Leena Ihantola, Jong H Kim, Heidi Hautajärvi, Elina Hankala, Marko Suokas, Johanna Pohjanen, Olga Podolich, Natalia Kozyrovska, Ari Turpeinen, Mirva Pääkkönen, Sampo Mattila, Bruce C Campbell & Anna Maria Pirttilä

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Optoepigenetics: An acetylation photoswitch

March 14th, 2016 by Andreas S Madsen

Nature Chemical Biology 12, 306 (2016). doi:10.1038/nchembio.2049

Authors: Andreas S Madsen & Christian A Olsen

Histone 3 lysine 9 acetylation (H3K9ac) levels were modulated by photoresponsive histone deacetylase (HDAC) inhibitors to perturb the transcription of genes involved in cell cycle regulation and mitochondrial function.