A pyridoxal phosphate–dependent enzyme that oxidizes an unactivated carbon-carbon bond

January 25th, 2016 by Yi-Ling Du

Nature Chemical Biology 12, 194 (2016). doi:10.1038/nchembio.2009

Authors: Yi-Ling Du, Rahul Singh, Lona M Alkhalaf, Eugene Kuatsjah, Hai-Yan He, Lindsay D Eltis & Katherine S Ryan

  • Posted in Nat Chem Biol, Publications
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A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

January 25th, 2016 by Jacob I Stuckey

Nature Chemical Biology 12, 180 (2016). doi:10.1038/nchembio.2007

Authors: Jacob I Stuckey, Bradley M Dickson, Nancy Cheng, Yanli Liu, Jacqueline L Norris, Stephanie H Cholensky, Wolfram Tempel, Su Qin, Katherine G Huber, Cari Sagum, Karynne Black, Fengling Li, Xi-Ping Huang, Bryan L Roth, Brandi M Baughman, Guillermo Senisterra, Samantha G Pattenden, Masoud Vedadi, Peter J Brown, Mark T Bedford, Jinrong Min, Cheryl H Arrowsmith, Lindsey I James & Stephen V Frye

  • Posted in Nat Chem Biol, Publications
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A two-state activation mechanism controls the histone methyltransferase Suv39h1

January 25th, 2016 by Manuel M Müller

Nature Chemical Biology 12, 188 (2016). doi:10.1038/nchembio.2008

Authors: Manuel M Müller, Beat Fierz, Lenka Bittova, Glen Liszczak & Tom W Muir

  • Posted in Nat Chem Biol, Publications
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Oxidative damage: A pathway to stress

January 19th, 2016 by Stéphane Larochelle

Nature Chemical Biology 12, 53 (2016). doi:10.1038/nchembio.2013

Author: Stéphane Larochelle

Fatty acylation of Wnt proteins

January 19th, 2016 by Aaron H Nile

Nature Chemical Biology 12, 60 (2016). doi:10.1038/nchembio.2005

Authors: Aaron H Nile & Rami N Hannoush

Synthetic biology: Building genetic containment

January 19th, 2016 by Karmella A Haynes

Nature Chemical Biology 12, 55 (2016). doi:10.1038/nchembio.2004

Author: Karmella A Haynes

Since the 1980s, scientists have worked on designing genetic codes to reinforce containment and control of genetically engineered microbes. New mechanistic studies of “deadman” and “passcode” gene circuits provide a flexible platform to build new safety switches.

Chemical probes: The many genes of drug mechanism

January 19th, 2016 by Adam C Palmer

Nature Chemical Biology 12, 57 (2016). doi:10.1038/nchembio.2010

Author: Adam C Palmer

A small molecule's biological activity in a cell depends on the actions of many gene products. Correlations between basal gene expression and compound sensitivity across hundreds of human cell lines reveal a broad view of cellular mechanisms of action.

Protein aggregation: A rescue by chaperones

January 19th, 2016 by Joost Schymkowitz

Nature Chemical Biology 12, 58 (2016). doi:10.1038/nchembio.2006

Authors: Joost Schymkowitz & Frederic Rousseau

Protein aggregation is associated with more than 50 human pathologies, including prevalent conditions such as Alzheimer's and Parkinson's diseases. A phenotypic screen in Escherichia coli associating antibiotic resistance with the inhibition of protein aggregation now allows screening for chemical inhibitors of protein aggregation in a simple, fast and inexpensive manner.

Neurobiology: Tracking the scent

January 19th, 2016 by Catherine Goodman

Nature Chemical Biology 12, 53 (2016). doi:10.1038/nchembio.2011

Author: Catherine Goodman

Metalloenzymes: Getting the gold

January 19th, 2016 by Catherine Goodman

Nature Chemical Biology 12, 53 (2016). doi:10.1038/nchembio.2014

Author: Catherine Goodman