Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

August 22nd, 2016 by Zhong-Rui Li

Nature Chemical Biology 12, 773 (2016). doi:10.1038/nchembio.2157

Authors: Zhong-Rui Li, Jie Li, Jin-Ping Gu, Jennifer Y H Lai, Brendan M Duggan, Wei-Peng Zhang, Zhi-Long Li, Yong-Xin Li, Rong-Biao Tong, Ying Xu, Dong-Hai Lin, Bradley S Moore & Pei-Yuan Qian

Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.

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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

August 22nd, 2016 by Lavoisier Ramos-Espiritu

Nature Chemical Biology 12, 838 (2016). doi:10.1038/nchembio.2151

Authors: Lavoisier Ramos-Espiritu, Silke Kleinboelting, Felipe A Navarrete, Antonio Alvau, Pablo E Visconti, Federica Valsecchi, Anatoly Starkov, Giovanni Manfredi, Hannes Buck, Carolina Adura, Jonathan H Zippin, Joop van den Heuvel, J Fraser Glickman, Clemens Steegborn, Lonny R Levin & Jochen Buck

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Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

August 22nd, 2016 by Gregory H Bird

Nature Chemical Biology 12, 845 (2016). doi:10.1038/nchembio.2153

Authors: Gregory H Bird, Emanuele Mazzola, Kwadwo Opoku-Nsiah, Margaret A Lammert, Marina Godes, Donna S Neuberg & Loren D Walensky

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Oxidation increases the strength of the methionine-aromatic interaction

August 22nd, 2016 by Andrew K Lewis

Nature Chemical Biology 12, 860 (2016). doi:10.1038/nchembio.2159

Authors: Andrew K Lewis, Katie M Dunleavy, Tiffany L Senkow, Cheng Her, Benjamin T Horn, Mark A Jersett, Ryan Mahling, Megan R McCarthy, Gabriella T Perell, Christopher C Valley, Christine B Karim, Jiali Gao, William C K Pomerantz, David D Thomas, Alessandro Cembran, Anne Hinderliter & Jonathan N Sachs

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Insights into newly discovered marks and readers of epigenetic information

August 18th, 2016 by Forest H Andrews

Nature Chemical Biology 12, 662 (2016). doi:10.1038/nchembio.2149

Authors: Forest H Andrews, Brian D Strahl & Tatiana G Kutateladze

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Innate immunity: A sweet switch

August 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 657 (2016). doi:10.1038/nchembio.2162

Author: Terry L. Sheppard

Target validation: Switching domains

August 18th, 2016 by Alessio Ciulli

Nature Chemical Biology 12, 659 (2016). doi:10.1038/nchembio.2154

Author: Alessio Ciulli

Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.

Chemical synthesis: Linking up lysines

August 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 657 (2016). doi:10.1038/nchembio.2163

Author: Caitlin Deane

Small-Molecule inhibitors: Weed-control measures

August 18th, 2016 by Koichi Yoneyama

Nature Chemical Biology 12, 658 (2016). doi:10.1038/nchembio.2155

Author: Koichi Yoneyama

A high-throughput screen in the model plant Arabidopsis unveils leads for potential agents to combat Striga, a devastating root parasitic weed that affects food crops in Sub-Saharan Africa.

Gut microbiome: Branching into metabolic disease

August 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 657 (2016). doi:10.1038/nchembio.2164

Author: Mirella Bucci