Precursors of tRNAs are stabilized by methylguanosine cap structures

June 27th, 2016 by Takayuki Ohira

Nature Chemical Biology 12, 648 (2016). doi:10.1038/nchembio.2117

Authors: Takayuki Ohira & Tsutomu Suzuki

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

June 27th, 2016 by Andrew J Mitchell

Nature Chemical Biology 12, 636 (2016). doi:10.1038/nchembio.2112

Authors: Andrew J Mitchell, Qin Zhu, Ailiena O Maggiolo, Nikhil R Ananth, Matthew L Hillwig, Xinyu Liu & Amie K Boal

  • Posted in Nat Chem Biol, Publications
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Identifying the functional contribution of the defatty-acylase activity of SIRT6

June 20th, 2016 by Xiaoyu Zhang

Nature Chemical Biology 12, 614 (2016). doi:10.1038/nchembio.2106

Authors: Xiaoyu Zhang, Saba Khan, Hong Jiang, Marc A Antonyak, Xiao Chen, Nicole A Spiegelman, Jonathan H Shrimp, Richard A Cerione & Hening Lin

  • Posted in Nat Chem Biol, Publications
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A family of metal-dependent phosphatases implicated in metabolite damage-control

June 20th, 2016 by Lili Huang

Nature Chemical Biology 12, 621 (2016). doi:10.1038/nchembio.2108

Authors: Lili Huang, Anna Khusnutdinova, Boguslaw Nocek, Greg Brown, Xiaohui Xu, Hong Cui, Pierre Petit, Robert Flick, Rémi Zallot, Kelly Balmant, Michael J Ziemak, John Shanklin, Valérie de Crécy-Lagard, Oliver Fiehn, Jesse F Gregory, Andrzej Joachimiak, Alexei Savchenko, Alexander F Yakunin & Andrew D Hanson

  • Posted in Nat Chem Biol, Publications
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Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

June 20th, 2016 by Andrea Schulze

Nature Chemical Biology 12, 628 (2016). doi:10.1038/nchembio.2111

Authors: Andrea Schulze, Gerti Beliu, Dominic A Helmerich, Jonathan Schubert, Laurence H Pearl, Chrisostomos Prodromou & Hannes Neuweiler

  • Posted in Nat Chem Biol, Publications
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Progress and prospects for small-molecule probes of bacterial imaging

June 17th, 2016 by Ozden Kocaoglu

Nature Chemical Biology 12, 472 (2016). doi:10.1038/nchembio.2109

Authors: Ozden Kocaoglu & Erin E Carlson

  • Posted in Nat Chem Biol, Publications
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RNA structure: PARISian arches

June 17th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2121

Author: Terry L. Sheppard

Chromatin targeting: A BET inhibitor workaround

June 17th, 2016 by Christopher J Burns

Nature Chemical Biology 12, 469 (2016). doi:10.1038/nchembio.2107

Author: Christopher J Burns

A phenotypic cell-based screen identifies an inhibitor of BET bromodomain transcriptional activity via inhibition of the alternative bromodomain-containing protein TAF1.

Methanogenesis: A radical approach

June 17th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2122

Author: Caitlin Deane

Drug discovery: Zebrafish uncover novel antipsychotics

June 17th, 2016 by Louis C Leung

Nature Chemical Biology 12, 468 (2016). doi:10.1038/nchembio.2114

Authors: Louis C Leung & Philippe Mourrain

Two independent high-throughput zebrafish behavioral screens of tens of thousands of compounds identify the 'finazines', a novel group of antipsychotics, and their endogenous genetic target, the σ1 receptor.