Allosteric substrate switching in a voltage-sensing lipid phosphatase

February 15th, 2016 by Sasha S Grimm

Nature Chemical Biology 12, 261 (2016). doi:10.1038/nchembio.2022

Authors: Sasha S Grimm & Ehud Y Isacoff

  • Posted in Nat Chem Biol, Publications
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Allostery: A lipid two-step

February 15th, 2016 by Liang Hong

Nature Chemical Biology 12, 202 (2016). doi:10.1038/nchembio.2037

Authors: Liang Hong & Francesco Tombola

A sensor of membrane depolarization controls the activity of a bound enzyme through a novel mechanism involving two sequential voltage-dependent transitions allosterically coupled to changes in the substrate specificity of the catalytic domain.

YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids

February 15th, 2016 by Gaetano Speciale

Nature Chemical Biology 12, 215 (2016). doi:10.1038/nchembio.2023

Authors: Gaetano Speciale, Yi Jin, Gideon J Davies, Spencer J Williams & Ethan D Goddard-Borger

Sulfoquinovose is produced by photosynthetic organisms at a rate of 1010 tons per annum and is degraded by bacteria as a source of carbon and sulfur. We have identified Escherichia coli YihQ as the first dedicated sulfoquinovosidase and the gateway enzyme to sulfoglycolytic pathways. Structural and mutagenesis studies unveiled the sequence signatures for binding the distinguishing sulfonate residue and revealed that sulfoquinovoside degradation is widespread across the tree of life.

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Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome

February 10th, 2016 by Xiaoyu Li

Nature Chemical Biology 12, 311 (2016). doi:10.1038/nchembio.2040

Authors: Xiaoyu Li, Xushen Xiong, Kun Wang, Lixia Wang, Xiaoting Shu, Shiqing Ma & Chengqi Yi

  • Posted in Nat Chem Biol, Publications
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A transcription activator–like effector (TALE) induction system mediated by proteolysis

February 8th, 2016 by Matthew F Copeland

Nature Chemical Biology 12, 254 (2016). doi:10.1038/nchembio.2021

Authors: Matthew F Copeland, Mark C Politz, Charles B Johnson, Andrew L Markley & Brian F Pfleger

  • Posted in Nat Chem Biol, Publications
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A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

February 8th, 2016 by Jessika Valero-González

Nature Chemical Biology 12, 240 (2016). doi:10.1038/nchembio.2019

Authors: Jessika Valero-González, Christina Leonhard-Melief, Erandi Lira-Navarrete, Gonzalo Jiménez-Osés, Cristina Hernández-Ruiz, María Carmen Pallarés, Inmaculada Yruela, Deepika Vasudevan, Anabel Lostao, Francisco Corzana, Hideyuki Takeuchi, Robert S Haltiwanger & Ramon Hurtado-Guerrero

  • Posted in Nat Chem Biol, Publications
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Engineering nonphosphorylative metabolism to generate lignocellulose-derived products

February 8th, 2016 by Yi-Shu Tai

Nature Chemical Biology 12, 247 (2016). doi:10.1038/nchembio.2020

Authors: Yi-Shu Tai, Mingyong Xiong, Pooja Jambunathan, Jingyu Wang, Jilong Wang, Cole Stapleton & Kechun Zhang

  • Posted in Nat Chem Biol, Publications
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Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

February 1st, 2016 by Fei Mo

Nature Chemical Biology 12, 226 (2016). doi:10.1038/nchembio.2017

Authors: Fei Mo, Xiaoxuan Zhuang, Xing Liu, Phil Y Yao, Bo Qin, Zeqi Su, Jianye Zang, Zhiyong Wang, Jiancun Zhang, Zhen Dou, Changlin Tian, Maikun Teng, Liwen Niu, Donald L Hill, Guowei Fang, Xia Ding, Chuanhai Fu & Xuebiao Yao

  • Posted in Nat Chem Biol, Publications
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Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

February 1st, 2016 by Panayotis C Theodoropoulos

Nature Chemical Biology 12, 218 (2016). doi:10.1038/nchembio.2016

Authors: Panayotis C Theodoropoulos, Stephen S Gonzales, Sarah E Winterton, Carlos Rodriguez-Navas, John S McKnight, Lorraine K Morlock, Jordan M Hanson, Bethany Cross, Amy E Owen, Yingli Duan, Jose R Moreno, Andrew Lemoff, Hamid Mirzaei, Bruce A Posner, Noelle S Williams, Joseph M Ready & Deepak Nijhawan

  • Posted in Nat Chem Biol, Publications
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Assembly and clustering of natural antibiotics guides target identification

February 1st, 2016 by Chad W Johnston

Nature Chemical Biology 12, 233 (2016). doi:10.1038/nchembio.2018

Authors: Chad W Johnston, Michael A Skinnider, Chris A Dejong, Philip N Rees, Gregory M Chen, Chelsea G Walker, Shawn French, Eric D Brown, János Bérdy, Dennis Y Liu & Nathan A Magarvey

  • Posted in Nat Chem Biol, Publications
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