Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

May 16th, 2016 by Lisandro J González

Nature Chemical Biology 12, 516 (2016). doi:10.1038/nchembio.2083

Authors: Lisandro J González, Guillermo Bahr, Toshiki G Nakashige, Elizabeth M Nolan, Robert A Bonomo & Alejandro J Vila

  • Posted in Nat Chem Biol, Publications
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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

May 9th, 2016 by Kenichi Shimada

Nature Chemical Biology 12, 497 (2016). doi:10.1038/nchembio.2079

Authors: Kenichi Shimada, Rachid Skouta, Anna Kaplan, Wan Seok Yang, Miki Hayano, Scott J Dixon, Lewis M Brown, Carlos A Valenzuela, Adam J Wolpaw & Brent R Stockwell

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Prdm4 induction by the small molecule butein promotes white adipose tissue browning

May 9th, 2016 by No-Joon Song

Nature Chemical Biology 12, 479 (2016). doi:10.1038/nchembio.2081

Authors: No-Joon Song, Seri Choi, Prashant Rajbhandari, Seo-Hyuk Chang, Suji Kim, Laurent Vergnes, So-Mi Kwon, Jung-Hoon Yoon, Sukchan Lee, Jin-Mo Ku, Jeong-Soo Lee, Karen Reue, Seung-Hoi Koo, Peter Tontonoz & Kye Won Park

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

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Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

May 9th, 2016 by Sara Sdelci

Nature Chemical Biology 12, 504 (2016). doi:10.1038/nchembio.2080

Authors: Sara Sdelci, Charles-Hugues Lardeau, Cynthia Tallant, Freya Klepsch, Björn Klaiber, James Bennett, Philipp Rathert, Michael Schuster, Thomas Penz, Oleg Fedorov, Giulio Superti-Furga, Christoph Bock, Johannes Zuber, Kilian V M Huber, Stefan Knapp, Susanne Müller & Stefan Kubicek

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Metabolite concentrations, fluxes and free energies imply efficient enzyme usage

May 2nd, 2016 by Junyoung O Park

Nature Chemical Biology 12, 482 (2016). doi:10.1038/nchembio.2077

Authors: Junyoung O Park, Sara A Rubin, Yi-Fan Xu, Daniel Amador-Noguez, Jing Fan, Tomer Shlomi & Joshua D Rabinowitz

  • Posted in Nat Chem Biol, Publications
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An intrinsically disordered entropic switch determines allostery in Phd–Doc regulation

May 2nd, 2016 by Abel Garcia-Pino

Nature Chemical Biology 12, 490 (2016). doi:10.1038/nchembio.2078

Authors: Abel Garcia-Pino, Steven De Gieter, Ariel Talavera, Henri De Greve, Rouslan G Efremov & Remy Loris

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

April 25th, 2016 by Michael E Pacold

Nature Chemical Biology 12, 452 (2016). doi:10.1038/nchembio.2070

Authors: Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, Jason M Rohde, Caroline A Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W Chen, Lucas B Sullivan, Brian P Fiske, Steve Cho, Elizaveta Freinkman, Kıvanç Birsoy, Monther Abu-Remaileh, Yoav D Shaul, Chieh Min Liu, Minerva Zhou, Min Jung Koh, Haeyoon Chung, Shawn M Davidson, Alba Luengo, Amy Q Wang, Xin Xu, Adam Yasgar, Li Liu, Ganesha Rai, Kenneth D Westover, Matthew G Vander Heiden, Min Shen, Nathanael S Gray, Matthew B Boxer & David M Sabatini

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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

April 25th, 2016 by Kumar N Alagramam

Nature Chemical Biology 12, 444 (2016). doi:10.1038/nchembio.2069

Authors: Kumar N Alagramam, Suhasini R Gopal, Ruishuang Geng, Daniel H-C Chen, Ina Nemet, Richard Lee, Guilian Tian, Masaru Miyagi, Karine F Malagu, Christopher J Lock, William R K Esmieu, Andrew P Owens, Nicola A Lindsay, Krista Ouwehand, Faywell Albertus, David F Fischer, Roland W Bürli, Angus M MacLeod, William E Harte, Krzysztof Palczewski & Yoshikazu Imanishi

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Click-EM for imaging metabolically tagged nonprotein biomolecules

April 25th, 2016 by John T Ngo

Nature Chemical Biology 12, 459 (2016). doi:10.1038/nchembio.2076

Authors: John T Ngo, Stephen R Adams, Thomas J Deerinck, Daniela Boassa, Frances Rodriguez-Rivera, Sakina F Palida, Carolyn R Bertozzi, Mark H Ellisman & Roger Y Tsien

Inflammation: Dietary stress relief

April 19th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 305 (2016). doi:10.1038/nchembio.2075

Author: Mirella Bucci