Genomics: A Tribe for RNA

May 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2092

Author: Grant Miura

Protein evolution: Polymerase’s new language

May 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2094

Author: Caitlin Deane

Proteostasis: Chaperoning for hearing loss

May 18th, 2016 by Gergely L Lukacs

Nature Chemical Biology 12, 388 (2016). doi:10.1038/nchembio.2091

Author: Gergely L Lukacs

A small molecule has been identified that can mitigate the progression of an inherited form of deafness in transgenic mice by stabilizing mutant clarin-1, an essential component of a multimolecular complex of the mechanotransduction apparatus of hair cells in the inner ear.

Metalloproteins: Mapping elusive electron density

May 18th, 2016 by Louis Noodleman

Nature Chemical Biology 12, 391 (2016). doi:10.1038/nchembio.2088

Author: Louis Noodleman

Iron–sulfur metalloproteins are critical for electron transfer in bacterial metabolism, but most crystal structures are insufficient for their in-depth study. Now, acquisition of an iron–sulfur protein structure at ultra-high resolution enables detailed visualization of its electron distribution.

Cancer metabolism: Addicted to serine

May 18th, 2016 by Christian Frezza

Nature Chemical Biology 12, 389 (2016). doi:10.1038/nchembio.2086

Author: Christian Frezza

Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors selectively block proliferation of PHGDH-dependent cancer cells and reveal an unexpected role of serine biosynthesis in coordinating one-carbon metabolism.

Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera

May 18th, 2016 by Stavroula K Hatzios

Nature Chemical Biology 12, 466 (2016). doi:10.1038/nchembio0616-466

Author: Stavroula K Hatzios, Sören Abel, Julianne Martell, Troy Hubbard, Jumpei Sasabe, Diana Munera, Lars Clark, Daniel A Bachovchin, Firdausi Qadri, Edward T Ryan, Brigid M Davis, Eranthie Weerapana & Matthew K Waldor

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera

Lighting the way

May 18th, 2016 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 12, 381 (2016). doi:10.1038/nchembio.2101

The innovation and optimization of optogenetic tools are providing new insights into biological and cellular processes with unparalleled spatiotemporal resolution.

Gene expression: Means to an end

May 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2093

Author: Terry L. Sheppard

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

May 16th, 2016 by Ting Han

Nature Chemical Biology 12, 511 (2016). doi:10.1038/nchembio.2082

Authors: Ting Han, Maria Goralski, Emanuela Capota, Shae B Padrick, Jiwoong Kim, Yang Xie & Deepak Nijhawan

A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

May 16th, 2016 by Monique P C Mulder

Nature Chemical Biology 12, 523 (2016). doi:10.1038/nchembio.2084

Authors: Monique P C Mulder, Katharina Witting, Ilana Berlin, Jonathan N Pruneda, Kuen-Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C O Vertegaal, Brenda A Schulman, David Komander, Jacques Neefjes, Farid El Oualid & Huib Ovaa

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes