Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

July 25th, 2016 by Yasuyuki Miyake

Nature Chemical Biology 12, 748 (2016). doi:10.1038/nchembio.2140

Authors: Yasuyuki Miyake, Jeremy J Keusch, Longlong Wang, Makoto Saito, Daniel Hess, Xiaoning Wang, Bruce J Melancon, Paul Helquist, Heinz Gut & Patrick Matthias

  • Posted in Nat Chem Biol, Publications
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Photoswitchable diacylglycerols enable optical control of protein kinase C

July 25th, 2016 by James Allen Frank

Nature Chemical Biology 12, 755 (2016). doi:10.1038/nchembio.2141

Authors: James Allen Frank, Dmytro A Yushchenko, David J Hodson, Noa Lipstein, Jatin Nagpal, Guy A Rutter, Jeong-Seop Rhee, Alexander Gottschalk, Nils Brose, Carsten Schultz & Dirk Trauner

  • Posted in Nat Chem Biol, Publications
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Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

July 25th, 2016 by Yang Hai

Nature Chemical Biology 12, 741 (2016). doi:10.1038/nchembio.2134

Authors: Yang Hai & David W Christianson

  • Posted in Nat Chem Biol, Publications
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Proteostasis: TSA1 to the rescue

July 19th, 2016 by Grant Miura

Nature Chemical Biology 12, 575 (2016). doi:10.1038/nchembio.2138

Author: Grant Miura

Metabolism: A new layer of glycolysis

July 19th, 2016 by Maria V Liberti

Nature Chemical Biology 12, 577 (2016). doi:10.1038/nchembio.2133

Authors: Maria V Liberti & Jason W Locasale

Glucose metabolism has long been thought to operate with exquisite specificity and near-optimal efficiency. New findings show, however, that two glycolytic enzymes produce minor products that inhibit other enzymes involved in central carbon metabolism unless they are further metabolized by a novel enzyme.

Biosynthesis: Metal-pilfering pathogens

July 19th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 575 (2016). doi:10.1038/nchembio.2139

Author: Caitlin Deane

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

July 19th, 2016 by Michael E Pacold

Nature Chemical Biology 12, 656 (2016). doi:10.1038/nchembio0816-656

Author: Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, Jason M Rohde, Caroline A Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W Chen, Lucas B Sullivan, Brian P Fiske, Steve Cho, Elizaveta Freinkman, Kıvanç Birsoy, Monther-Remaileh Abu, Yoav D Shaul, Chieh Min Liu, Minerva Zhou, Min Jung Koh, Haeyoon Chung, Shawn M Davidson, Alba Luengo, Amy Q Wang, Xin Xu, Adam Yasgar, Li Liu, Ganesha Rai, Kenneth D Westover, Matthew G Vander Heiden, Min Shen, Nathanael S Gray, Matthew B Boxer & David M Sabatini

  • Posted in Nat Chem Biol, Publications
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Chaperones: Speedy motion for function

July 19th, 2016 by Hagen Hofmann

Nature Chemical Biology 12, 576 (2016). doi:10.1038/nchembio.2130

Author: Hagen Hofmann

Hsp90 is an energy-consuming molecular chaperone that activates oncogenic proteins in a complicated multi-step reaction. Photoinduced electron transfer (PET) quenching experiments with a fluorescent reporter have now identified molecular transitions at multiple timescales in the chaperone cycle of Hsp90.

Antibiotics: I want a new drug

July 19th, 2016 by Joshua M. Finkelstein

Nature Chemical Biology 12, 575 (2016). doi:10.1038/nchembio.2137

Author: Joshua M. Finkelstein

Glycomics: Highlights for carbohydrates

July 19th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 575 (2016). doi:10.1038/nchembio.2136

Author: Terry L. Sheppard