SF2312 is a natural phosphonate inhibitor of enolase

October 10th, 2016 by Paul G Leonard

Nature Chemical Biology 12, 1053 (2016). doi:10.1038/nchembio.2195

Authors: Paul G Leonard, Nikunj Satani, David Maxwell, Yu-Hsi Lin, Naima Hammoudi, Zhenghong Peng, Federica Pisaneschi, Todd M Link, Gilbert R Lee, Duoli Sun, Basvoju A Bhanu Prasad, Maria Emilia Di Francesco, Barbara Czako, John M Asara, Y Alan Wang, William Bornmann, Ronald A DePinho & Florian L Muller

Serine is a new target residue for endogenous ADP-ribosylation on histones

October 10th, 2016 by Orsolya Leidecker

Nature Chemical Biology 12, 998 (2016). doi:10.1038/nchembio.2180

Authors: Orsolya Leidecker, Juan José Bonfiglio, Thomas Colby, Qi Zhang, Ilian Atanassov, Roko Zaja, Luca Palazzo, Anna Stockum, Ivan Ahel & Ivan Matic

ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.

  • Posted in Nat Chem Biol, Publications
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A photoactivatable Cre–loxP recombination system for optogenetic genome engineering

October 10th, 2016 by Fuun Kawano

Nature Chemical Biology 12, 1059 (2016). doi:10.1038/nchembio.2205

Authors: Fuun Kawano, Risako Okazaki, Masayuki Yazawa & Moritoshi Sato

  • Posted in Nat Chem Biol, Publications
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Competing charge transfer pathways at the photosystem II–electrode interface

October 10th, 2016 by Jenny Z Zhang

Nature Chemical Biology 12, 1046 (2016). doi:10.1038/nchembio.2192

Authors: Jenny Z Zhang, Katarzyna P Sokol, Nicholas Paul, Elisabet Romero, Rienk van Grondelle & Erwin Reisner

  • Posted in Nat Chem Biol, Publications
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Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection

October 10th, 2016 by Gahl Levy

Nature Chemical Biology 12, 1037 (2016). doi:10.1038/nchembio.2193

Authors: Gahl Levy, Naomi Habib, Maria Angela Guzzardi, Daniel Kitsberg, David Bomze, Elishai Ezra, Basak E Uygun, Korkut Uygun, Martin Trippler, Joerg F Schlaak, Oren Shibolet, Ella H Sklan, Merav Cohen, Joerg Timm, Nir Friedman & Yaakov Nahmias

  • Posted in Nat Chem Biol, Publications
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Enzymatic hydrolysis by transition-metal-dependent nucleophilic aromatic substitution

October 3rd, 2016 by Sibel Kalyoncu

Nature Chemical Biology 12, 1031 (2016). doi:10.1038/nchembio.2191

Authors: Sibel Kalyoncu, David P Heaner, Zohre Kurt, Casey M Bethel, Chiamaka U Ukachukwu, Srinivas Chakravarthy, Jim C Spain & Raquel L Lieberman

  • Posted in Nat Chem Biol, Publications
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Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching

October 3rd, 2016 by Chris A Dejong

Nature Chemical Biology 12, 1007 (2016). doi:10.1038/nchembio.2188

Authors: Chris A Dejong, Gregory M Chen, Haoxin Li, Chad W Johnston, Mclean R Edwards, Philip N Rees, Michael A Skinnider, Andrew L H Webster & Nathan A Magarvey

  • Posted in Nat Chem Biol, Publications
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Functional mining of transporters using synthetic selections

October 3rd, 2016 by Hans J Genee

Nature Chemical Biology 12, 1015 (2016). doi:10.1038/nchembio.2189

Authors: Hans J Genee, Anne P Bali, Søren D Petersen, Solvej Siedler, Mads T Bonde, Luisa S Gronenberg, Mette Kristensen, Scott J Harrison & Morten O A Sommer

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

October 3rd, 2016 by Cecilia Lopez-Sambrooks

Nature Chemical Biology 12, 1023 (2016). doi:10.1038/nchembio.2194

Authors: Cecilia Lopez-Sambrooks, Shiteshu Shrimal, Carol Khodier, Daniel P Flaherty, Natalie Rinis, Jonathan C Charest, Ningguo Gao, Peng Zhao, Lance Wells, Timothy A Lewis, Mark A Lehrman, Reid Gilmore, Jennifer E Golden & Joseph N Contessa

  • Posted in Nat Chem Biol, Publications
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Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification

October 3rd, 2016 by Zhewang Lin

Nature Chemical Biology 12, 995 (2016). doi:10.1038/nchembio.2190

Authors: Zhewang Lin, Min Dong, Yugang Zhang, Eunyoung Alisa Lee & Hening Lin

Diphthamide and the tRNA wobble uridine modifications both require diphthamide biosynthesis 3 (Dph3) protein as an electron donor for the iron-sulfur clusters in their biosynthetic enzymes. Here, using a proteomic approach, we identified Saccharomyces cerevisiae cytochrome b5 reductase (Cbr1) as a NADH-dependent reductase for Dph3. The NADH- and Cbr1-dependent reduction of Dph3 may provide a regulatory linkage between cellular metabolic state and protein translation.

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