Biosynthesis: Metal-pilfering pathogens

July 19th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 575 (2016). doi:10.1038/nchembio.2139

Author: Caitlin Deane

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

July 19th, 2016 by Michael E Pacold

Nature Chemical Biology 12, 656 (2016). doi:10.1038/nchembio0816-656

Author: Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, Jason M Rohde, Caroline A Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W Chen, Lucas B Sullivan, Brian P Fiske, Steve Cho, Elizaveta Freinkman, Kıvanç Birsoy, Monther-Remaileh Abu, Yoav D Shaul, Chieh Min Liu, Minerva Zhou, Min Jung Koh, Haeyoon Chung, Shawn M Davidson, Alba Luengo, Amy Q Wang, Xin Xu, Adam Yasgar, Li Liu, Ganesha Rai, Kenneth D Westover, Matthew G Vander Heiden, Min Shen, Nathanael S Gray, Matthew B Boxer & David M Sabatini

  • Posted in Nat Chem Biol, Publications
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Structure and function of the bacterial decapping enzyme NudC

July 18th, 2016 by Katharina Höfer

Nature Chemical Biology 12, 730 (2016). doi:10.1038/nchembio.2132

Authors: Katharina Höfer, Sisi Li, Florian Abele, Jens Frindert, Jasmin Schlotthauer, Julia Grawenhoff, Jiamu Du, Dinshaw J Patel & Andres Jäschke

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations

July 18th, 2016 by Hongjun Yu

Nature Chemical Biology 12, 735 (2016). doi:10.1038/nchembio.2135

Authors: Hongjun Yu, Hideyuki Takeuchi, Megumi Takeuchi, Qun Liu, Joshua Kantharia, Robert S Haltiwanger & Huilin Li

  • Posted in Nat Chem Biol, Publications
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Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins

July 18th, 2016 by Yu Chen

Nature Chemical Biology 12, 717 (2016). doi:10.1038/nchembio.2128

Authors: Yu Chen, Fan Yang, Lorena Zubovic, Tom Pavelitz, Wen Yang, Katherine Godin, Matthew Walker, Suxin Zheng, Paolo Macchi & Gabriele Varani

  • Posted in Nat Chem Biol, Publications
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Small-molecule antagonists of germination of the parasitic plant Striga hermonthica

July 18th, 2016 by Duncan Holbrook-Smith

Nature Chemical Biology 12, 724 (2016). doi:10.1038/nchembio.2129

Authors: Duncan Holbrook-Smith, Shigeo Toh, Yuichiro Tsuchiya & Peter McCourt

  • Posted in Nat Chem Biol, Publications
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Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage

July 11th, 2016 by Aiming Ren

Nature Chemical Biology 12, 702 (2016). doi:10.1038/nchembio.2125

Authors: Aiming Ren, Nikola Vušurović, Jennifer Gebetsberger, Pu Gao, Michael Juen, Christoph Kreutz, Ronald Micura & Dinshaw J Patel

  • Posted in Nat Chem Biol, Publications
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A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

July 11th, 2016 by Yuji Ogura

Nature Chemical Biology 12, 669 (2016). doi:10.1038/nchembio.2127

Authors: Yuji Ogura, William H Parsons, Siddhesh S Kamat & Benjamin F Cravatt

More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells.

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Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

July 11th, 2016 by Alem W Kahsai

Nature Chemical Biology 12, 709 (2016). doi:10.1038/nchembio.2126

Authors: Alem W Kahsai, James W Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J Cahill III, S Moses Dennison, Dean P Staus, Alex R B Thomsen, Kara M Anasti, Biswaranjan Pani, Laura M Wingler, Hemant Desai, Kristin M Bompiani, Ryan T Strachan, Xiaoxia Qin, S Munir Alam, Bruce A Sullenger & Robert J Lefkowitz

  • Posted in Nat Chem Biol, Publications
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Tbx16 regulates hox gene activation in mesodermal progenitor cells

July 4th, 2016 by Alexander Y Payumo

Nature Chemical Biology 12, 694 (2016). doi:10.1038/nchembio.2124

Authors: Alexander Y Payumo, Lindsey E McQuade, Whitney J Walker, Sayumi Yamazoe & James K Chen